Phosphatases are emerging as novel druggable targets in Plasmodium

UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages

(2016) Min Zhang et al.   PLoS Pathogens

Applying chemical genetic tools to the study of phospho-signalling pathways in malaria parasites

(2015) Deborah F. Mitcheson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design

(2015) Smita Mohanty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Targeting kinases in Plasmodium and Schistosoma : Same goals, different challenges

(2015) Christian Doerig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

CDK8 kinase—An emerging target in targeted cancer therapy

(2015) Tomasz Rzymski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation

(2014) David S. Guttery et al.   Cell Host & Microbe

Identification of aPlasmodium falciparuminhibitor-2 motif involved in the binding and regulation activity of protein phosphatase type 1

(2014) Aline Fréville et al.   FEBS Journal

A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites

(2014) Ann M. Guggisberg et al.   Nature Communications

Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy

(2013) Aline Fréville et al.   BMC BIOLOGY

Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum

(2012) Jürgen Bosch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Plasmodium falciparumInhibitor-3 Homolog Increases Protein Phosphatase Type 1 Activity and Is Essential for Parasitic Survival

(2011) Aline Fréville et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a new phosphatase from Plasmodium

(2011) Tanya Hills et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE