Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion

(2019) Christian Flueck et al.   PLOS BIOLOGY

Uncovering the essential genes of the human malaria parasitePlasmodium falciparumby saturation mutagenesis

(2018) Min Zhang et al.   SCIENCE

The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress

(2018) Abigail J. Perrin et al.   mBio

Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum

(2018) Sabrina Absalon et al.   mBio

Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii

(2018) Alessandro D. Uboldi et al.   PLOS BIOLOGY

Sensitive and Accurate Quantitation of Phosphopeptides Using TMT Isobaric Labeling Technique

(2017) Xiaoyue Jiang et al.   JOURNAL OF PROTEOME RESEARCH

A genetic system to study Plasmodium falciparum protein function

(2017) Jakob Birnbaum et al.   NATURE METHODS

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

(2017) Sudhir Kumar et al.   Nature Communications

Generating conditional gene knockouts in Plasmodium – a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9

(2017) Ellen Knuepfer et al.   Scientific Reports

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants

(2017) Antoine Claessens et al.   Scientific Reports

The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes

(2017) Christine R. Collins et al.   PLoS Pathogens

Structural and functional dissection ofToxoplasma gondiiarmadillo repeats only protein

(2016) Christina Mueller et al.   JOURNAL OF CELL SCIENCE

Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail

(2016) Shruthi Krishnamurthy et al.   mBio

A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum

(2016) Matthew L. Jones et al.   Scientific Reports

The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites

(2016) Kartik S. Bane et al.   PLoS Pathogens

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

(2016) Boris Prinz et al.   Scientific Reports

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs

(2015) Sujaan Das et al.   Cell Host & Microbe

Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites

(2015) Maya A Olshina et al.   MALARIA JOURNAL

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

(2015) Robert Stallmach et al.   MOLECULAR MICROBIOLOGY

Extensive differential protein phosphorylation as intraerythrocyticPlasmodium falciparumschizonts develop into extracellular invasive merozoites

(2015) Edwin Lasonder et al.   PROTEOMICS

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

(2015) Greta E. Weiss et al.   PLoS Pathogens

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide

(2014) Geqing Wang et al.   PLoS One

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes

(2014) Amrita Dawn et al.   PLoS Pathogens

Electron tomography ofPlasmodium falciparummerozoites reveals core cellular events that underpin erythrocyte invasion

(2013) Eric Hanssen et al.   CELLULAR MICROBIOLOGY

Robust inducible Cre recombinase activity in the human malaria parasitePlasmodium falciparumenables efficient gene deletion within a single asexual erythrocytic growth cycle

(2013) Christine R. Collins et al.   MOLECULAR MICROBIOLOGY

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

Characterization ofPlasmodium falciparumCalcium-dependent Protein Kinase 1 (PfCDPK1) and Its Role in Microneme Secretion during Erythrocyte Invasion

(2012) Abhisheka Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Plasmodium falciparum Schizont Phosphoproteome Reveals Extensive Phosphatidylinositol and cAMP-Protein Kinase A Signaling

(2012) Edwin Lasonder et al.   JOURNAL OF PROTEOME RESEARCH

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Characterization of Plasmodium falciparum Adenylyl Cyclase-β and Its Role in Erythrocytic Stage Parasites

(2012) Eric Salazar et al.   PLoS One

Structural and Functional Insights into the Malaria Parasite Moving Junction Complex

(2012) Brigitte Vulliez-Le Normand et al.   PLoS Pathogens

Global Identification of Multiple Substrates forPlasmodium falciparumSUB1, an Essential Malarial Processing Protease

(2011) Natalie C. Silmon de Monerri et al.   INFECTION AND IMMUNITY

Binding ofPlasmodiummerozoite proteins RON2 and AMA1 triggers commitment to invasion

(2011) Prakash Srinivasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies

(2011) Anna Olivieri et al.   PLoS Pathogens

The RON2-AMA1 Interaction is a Critical Step in Moving Junction-Dependent Invasion by Apicomplexan Parasites

(2011) Mauld Lamarque et al.   PLoS Pathogens

The C-Terminus of Toxoplasma RON2 Provides the Crucial Link between AMA1 and the Host-Associated Invasion Complex

(2011) Jessica S. Tyler et al.   PLoS Pathogens

Interaction betweenPlasmodium falciparumApical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites

(2010) Dave Richard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin triggers PKA activation in the rodent malaria parasite Plasmodium chabaudi

(2010) Marcos L. Gazarini et al.   JOURNAL OF PINEAL RESEARCH

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

(2010) Kerstin Leykauf et al.   PLoS Pathogens

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process

(2009) Moritz Treeck et al.   PLoS Pathogens

An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery

(2009) Christine R. Collins et al.   PLoS Pathogens

Epac and PKA: a tale of two intracellular cAMP receptors

(2008) Xiaodong Cheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Plasmodium falciparum Regulatory Subunit of cAMP-Dependent PKA and Anion Channel Conductance

(2008) Anaïs Merckx et al.   PLoS Pathogens

Adenylyl Cyclase α and cAMP Signaling Mediate Plasmodium Sporozoite Apical Regulated Exocytosis and Hepatocyte Infection

(2008) Takeshi Ono et al.   PLoS Pathogens