Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion

Evidence against a Role of Elevated Intracellular Ca 2+ during Plasmodium falciparum Preinvasion

(2018) Viola Introini et al.   BIOPHYSICAL JOURNAL

Uncovering the essential genes of the human malaria parasitePlasmodium falciparumby saturation mutagenesis

(2018) Min Zhang et al.   SCIENCE

Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii

(2018) Alessandro D. Uboldi et al.   PLOS BIOLOGY

Gliding motility powers invasion and egress in Apicomplexa

(2017) Karine Frénal et al.   NATURE REVIEWS MICROBIOLOGY

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

(2017) Sudhir Kumar et al.   Nature Communications

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

(2017) Markus Ganter et al.   Nature Microbiology

Plasmodium falciparum STEVOR phosphorylation regulates host erythrocyte deformability enabling malaria parasite transmission

(2016) B. Naissant et al.   BLOOD

Invasion of hepatocytes byPlasmodiumsporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4

(2016) K. Govindasamy et al.   MOLECULAR MICROBIOLOGY

2016 update of the PRIDE database and its related tools

(2016) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Toxoplasma gondii Cyclic AMP-Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development

(2016) Tatsuki Sugi et al.   mBio

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

(2016) Boris Prinz et al.   Scientific Reports

Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites

(2015) Brittany L. Howard et al.   ACS Chemical Biology

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

(2015) Robert Stallmach et al.   MOLECULAR MICROBIOLOGY

PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites

(2015) Frank Schwach et al.   NUCLEIC ACIDS RESEARCH

Extensive differential protein phosphorylation as intraerythrocyticPlasmodium falciparumschizonts develop into extracellular invasive merozoites

(2015) Edwin Lasonder et al.   PROTEOMICS

Cyclic GMP Balance Is Critical for Malaria Parasite Transmission from the Mosquito to the Mammalian Host

(2015) Viswanathan Lakshmanan et al.   mBio

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress

(2015) Rajshekhar Y. Gaji et al.   PLoS Pathogens

Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

(2015) Greta E. Weiss et al.   PLoS Pathogens

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission

(2015) Ghania Ramdani et al.   PLoS Pathogens

Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1

(2014) Katherine L. Harvey et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii

(2014) Qing Tang et al.   MOLECULAR BIOLOGY OF THE CELL

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets

(2014) F Ahmad et al.   ORAL DISEASES

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes

(2014) Amrita Dawn et al.   PLoS Pathogens

Robust inducible Cre recombinase activity in the human malaria parasitePlasmodium falciparumenables efficient gene deletion within a single asexual erythrocytic growth cycle

(2013) Christine R. Collins et al.   MOLECULAR MICROBIOLOGY

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data

(2012) Juergen Cox et al.   BMC BIOINFORMATICS

The Plasmodium falciparum Schizont Phosphoproteome Reveals Extensive Phosphatidylinositol and cAMP-Protein Kinase A Signaling

(2012) Edwin Lasonder et al.   JOURNAL OF PROTEOME RESEARCH

Melatonin triggers PKA activation in the rodent malaria parasite Plasmodium chabaudi

(2010) Marcos L. Gazarini et al.   JOURNAL OF PINEAL RESEARCH

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

(2010) J. D. Dvorin et al.   SCIENCE

Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

(2010) Shailja Singh et al.   PLoS Pathogens

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

(2010) Kerstin Leykauf et al.   PLoS Pathogens

The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

(2009) Helen M. Taylor et al.   EUKARYOTIC CELL

Role of Plasmodium berghei cGMP-dependent Protein Kinase in Late Liver Stage Development

(2009) Adebola Falae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite

(2009) Robert W. Moon et al.   PLoS Pathogens

An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery

(2009) Christine R. Collins et al.   PLoS Pathogens

Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEα, a non-essential cGMP-specific PDE that is an integral membrane protein

(2008) Laurent Wentzinger et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The Motor Complex ofPlasmodium falciparum

(2008) Judith L. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of aPlasmodium falciparumcyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis

(2008) Cathy J. Taylor et al.   MOLECULAR MICROBIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase

(2008) Louisa McRobert et al.   PLOS BIOLOGY

Adenylyl Cyclase α and cAMP Signaling Mediate Plasmodium Sporozoite Apical Regulated Exocytosis and Hepatocyte Infection

(2008) Takeshi Ono et al.   PLoS Pathogens