Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space

Traveling and standing waves mediate pattern formation in cellular protrusions

(2020) Sayak Bhattacharya et al.   Science Advances

Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins

(2019) Christof Litschko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells

(2019) Seiya Fukushima et al.   JOURNAL OF CELL SCIENCE

Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization

(2019) Tony Y.-C. Tsai et al.   DEVELOPMENTAL CELL

Phosphorylated Rho–GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras–GTP to regulate cell migration

(2019) Hiroshi Senoo et al.   NATURE CELL BIOLOGY

Persistent and polarized global actin flow is essential for directionality during cell migration

(2019) Lawrence Yolland et al.   NATURE CELL BIOLOGY

Cell confinement reveals a branched-actin independent circuit for neutrophil polarity

(2019) Brian R. Graziano et al.   PLOS BIOLOGY

Plasticity of cell migration resulting from mechanochemical coupling

(2019) Yuansheng Cao et al.   eLife

Insight from the maximal activation of the signal transduction excitable network inDictyostelium discoideum

(2018) Marc Edwards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rotation of stress fibers as a single wheel in migrating fish keratocytes

(2018) Chika Okimura et al.   Scientific Reports

Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells

(2018) Sergio Alonso et al.   PLoS One

Promoter-mediated diversification of transcriptional bursting dynamics following gene duplication

(2018) Edward Tunnacliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling cellular morphodynamics by spatiotemporal spectrum decomposition

(2018) Xiao Ma et al.   PLoS Computational Biology

Optogenetic dissection of Rac1 and Cdc42 gradient shaping

(2018) S. de Beco et al.   Nature Communications

WASP family proteins and formins compete in pseudopod- and bleb-based migration

(2017) Andrew J. Davidson et al.   JOURNAL OF CELL BIOLOGY

Dissecting the actin cortex density and membrane-cortex distance in living cells by super-resolution microscopy

(2017) M P Clausen et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

(2017) Peter J. M. van Haastert et al.   MOLECULAR BIOLOGY OF THE CELL

Altering the threshold of an excitable signal transduction network changes cell migratory modes

(2017) Yuchuan Miao et al.   NATURE CELL BIOLOGY

Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes

(2017) Lillian K Fritz-Laylin et al.   eLife

Plasticity of Cell Migration In Vivo and In Silico

(2016) Veronika te Boekhorst et al.   Annual Review of Cell and Developmental Biology

Measuring systematic changes in invasive cancer cell shape using Zernike moments

(2016) Elaheh Alizadeh et al.   Integrative Biology

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes

(2016) Alexander Leithner et al.   NATURE CELL BIOLOGY

Internetwork competition for monomers governs actin cytoskeleton organization

(2016) Cristian Suarez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deep Learning in Label-free Cell Classification

(2016) Claire Lifan Chen et al.   Scientific Reports

Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence

(2015) Paolo Maiuri et al.   CELL

Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase

(2015) Sunny S. Lou et al.   JOURNAL OF CELL BIOLOGY

Cell adhesion strength from cortical tension - an integration of concepts

(2015) R. Winklbauer   JOURNAL OF CELL SCIENCE

Linking morphodynamics and directional persistence of T lymphocyte migration

(2015) X. Liu et al.   Journal of the Royal Society Interface

Locally excitable Cdc42 signals steer cells during chemotaxis

(2015) Hee Won Yang et al.   NATURE CELL BIOLOGY

Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization

(2015) Alexis J. Lomakin et al.   NATURE CELL BIOLOGY

Homeostatic Actin Cytoskeleton Networks Are Regulated by Assembly Factor Competition for Monomers

(2014) Thomas A. Burke et al.   CURRENT BIOLOGY

Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis

(2014) Ming Tang et al.   Nature Communications

The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient

(2014) Ming-Jie Wang et al.   Cell Reports

Mathematical Modeling of Eukaryotic Cell Migration: Insights Beyond Experiments

(2013) Gaudenz Danuser et al.   Annual Review of Cell and Developmental Biology

GxcC connects Rap and Rac signaling during Dictyostelium development

(2013) Katarzyna Plak et al.   BMC CELL BIOLOGY

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes

(2013) Zheng Yin et al.   NATURE CELL BIOLOGY

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration

(2013) Chuan-Hsiang Huang et al.   NATURE CELL BIOLOGY

From simple to detailed models for cell polarization

(2013) L. Edelstein-Keshet et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Gleevec, an Abl Family Inhibitor, Produces a Profound Change in Cell Shape and Migration

(2013) Zaozao Chen et al.   PLoS One

Phase geometries of two-dimensional excitable waves govern self-organized morphodynamics of amoeboid cells

(2013) D. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct cell shapes determine accurate chemotaxis

(2013) Luke Tweedy et al.   Scientific Reports

Interaction of Motility, Directional Sensing, and Polarity Modules Recreates the Behaviors of Chemotaxing Cells

(2013) Changji Shi et al.   PLoS Computational Biology

Regimes of wave type patterning driven by refractory actin feedback: transition from static polarization to dynamic wave behaviour

(2012) W R Holmes et al.   PHYSICAL BIOLOGY

An Excitable Cortex and Memory Model Successfully Predicts New Pseudopod Dynamics

(2012) Robert M. Cooper et al.   PLoS One

Cell mechanics control rapid transitions between blebs and lamellipodia during migration

(2012) M. Bergert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Shape Dynamics: From Waves to Migration

(2012) Meghan K. Driscoll et al.   PLoS Computational Biology

Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour

(2011) Matthew P. Neilson et al.   PLOS BIOLOGY

Computational Model for Cell Morphodynamics

(2010) Danying Shao et al.   PHYSICAL REVIEW LETTERS

Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis

(2010) Hidenori Hattori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Onset of Collective Behavior in Social Amoebae

(2010) T. Gregor et al.   SCIENCE

A Conceptual Molecular Network for Chemotactic Behaviors Characterized by Feedback of Molecules Cycling Between the Membrane and the Cytosol

(2010) M. Otsuji et al.   Science Signaling

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Ordered Extension of Pseudopodia by Amoeboid Cells in the Absence of External Cues

(2009) Leonard Bosgraaf et al.   PLoS One

Wave-Pinning and Cell Polarity from a Bistable Reaction-Diffusion System

(2008) Yoichiro Mori et al.   BIOPHYSICAL JOURNAL

Mechanism of shape determination in motile cells

(2008) Kinneret Keren et al.   NATURE

Persistent Cell Motion in the Absence of External Signals: A Search Strategy for Eukaryotic Cells

(2008) Liang Li et al.   PLoS One

Functional Analysis of Spontaneous Cell Movement under Different Physiological Conditions

(2008) Hiroaki Takagi et al.   PLoS One