Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells

Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration

(2018) Xiaoguang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parallel signaling pathways regulate excitable dynamics differently to mediate pseudopod formation during eukaryotic chemotaxis

(2018) Yuki Tanabe et al.   JOURNAL OF CELL SCIENCE

Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells

(2018) Satomi Matsuoka et al.   Nature Communications

Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

(2017) Peter J. M. van Haastert et al.   MOLECULAR BIOLOGY OF THE CELL

Altering the threshold of an excitable signal transduction network changes cell migratory modes

(2017) Yuchuan Miao et al.   NATURE CELL BIOLOGY

Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells

(2017) Gregor Mönke et al.   Scientific Reports

Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells

(2016) Markus Lange et al.   JOURNAL OF CELL SCIENCE

Stochastic Switching of Cell Fate in Microbes

(2015) Thomas M. Norman et al.   Annual Review of Microbiology

Sec14-nodulin proteins and the patterning of phosphoinositide landmarks for developmental control of membrane morphogenesis

(2015) Ratna Ghosh et al.   MOLECULAR BIOLOGY OF THE CELL

Locally excitable Cdc42 signals steer cells during chemotaxis

(2015) Hee Won Yang et al.   NATURE CELL BIOLOGY

Excitable Signal Transduction Induces Both Spontaneous and Directional Cell Asymmetries in the Phosphatidylinositol Lipid Signaling System for Eukaryotic Chemotaxis

(2014) Masatoshi Nishikawa et al.   BIOPHYSICAL JOURNAL

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

(2014) Yulia Artemenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A PIP5 Kinase Essential for Efficient Chemotactic Signaling

(2014) Louise Fets et al.   CURRENT BIOLOGY

Actin and PIP3 waves in giant cells reveal the inherent length scale of an excited state

(2014) Matthias Gerhardt et al.   JOURNAL OF CELL SCIENCE

Modeling self-organized spatio-temporal patterns of PIP3and PTEN during spontaneous cell polarization

(2014) Fabian Knoch et al.   PHYSICAL BIOLOGY

Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis

(2014) Ming Tang et al.   Nature Communications

Intracellular Encoding of Spatiotemporal Guidance Cues in a Self-Organizing Signaling System for Chemotaxis in Dictyostelium Cells

(2013) Tatsuo Shibata et al.   BIOPHYSICAL JOURNAL

Gradient sensing during chemotaxis

(2013) Tian Jin   CURRENT OPINION IN CELL BIOLOGY

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration

(2013) Chuan-Hsiang Huang et al.   NATURE CELL BIOLOGY

Rho GTPases orient directional sensing in chemotaxis

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitable behavior in amoeboid chemotaxis

(2013) Changji Shi et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Asymmetric PTEN Distribution Regulated by Spatial Heterogeneity in Membrane-Binding State Transitions

(2013) Satomi Matsuoka et al.   PLoS Computational Biology

PIP3 Waves and PTEN Dynamics in the Emergence of Cell Polarity

(2012) Günther Gerisch et al.   BIOPHYSICAL JOURNAL

Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses

(2012) Kamalakkannan Srinivasan et al.   JOURNAL OF CELL SCIENCE

Modeling the self-organized phosphatidylinositol lipid signaling system in chemotactic cells using quantitative image analysis

(2012) T. Shibata et al.   JOURNAL OF CELL SCIENCE

Different modes of state transitions determine pattern in the Phosphatidylinositide-Actin system

(2011) Günther Gerisch et al.   BMC CELL BIOLOGY

Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

(2011) Arjan Kortholt et al.   EMBO REPORTS

Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells

(2010) Alexander Loewer et al.   CELL

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

Cells navigate with a local-excitation, global-inhibition-biased excitable network

(2010) Y. Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-organization of the phosphatidylinositol lipids signaling system for random cell migration

(2010) Y. Arai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-organizing actin waves as planar phagocytic cup structures

(2010) Guenther Gerisch et al.   Cell Adhesion & Migration

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

(2009) M. C. Weiger et al.   JOURNAL OF CELL SCIENCE

Chemotaxis: finding the way forward with Dictyostelium

(2009) Jason S. King et al.   TRENDS IN CELL BIOLOGY

Directional sensing during chemotaxis

(2008) Christopher Janetopoulos et al.   FEBS LETTERS

Four key signaling pathways mediating chemotaxis inDictyostelium discoideum

(2008) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

Self-organization in cell biology: a brief history

(2008) Eric Karsenti   NATURE REVIEWS MOLECULAR CELL BIOLOGY