Profiling cellular morphodynamics by spatiotemporal spectrum decomposition

Applications in image-based profiling of perturbations

(2016) Juan C Caicedo et al.   CURRENT OPINION IN BIOTECHNOLOGY

Morphological single cell profiling of the epithelial–mesenchymal transition

(2016) Susan E. Leggett et al.   Integrative Biology

Time series modeling of live-cell shape dynamics for image-based phenotypic profiling

(2016) Simon Gordonov et al.   Integrative Biology

Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling

(2016) Ludovico Fusco et al.   JOURNAL OF CELL BIOLOGY

FRET binding antenna reports spatiotemporal dynamics of GDI–Cdc42 GTPase interactions

(2016) Louis Hodgson et al.   Nature Chemical Biology

LOVTRAP: an optogenetic system for photoinduced protein dissociation

(2016) Hui Wang et al.   NATURE METHODS

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

Engineering extrinsic disorder to control protein activity in living cells

(2016) Onur Dagliyan et al.   SCIENCE

Modeling cell shape and dynamics on micropatterns

(2016) Philipp J. Albert et al.   Cell Adhesion & Migration

Cell Shape Dynamics Reveal Balance of Elasticity and Contractility in Peripheral Arcs

(2015) Céline Labouesse et al.   BIOPHYSICAL JOURNAL

Open source software for quantification of cell migration, protrusions, and fluorescence intensities

(2015) David J. Barry et al.   JOURNAL OF CELL BIOLOGY

Cytoskeletal dynamics: A view from the membrane

(2015) Magdalena Bezanilla et al.   JOURNAL OF CELL BIOLOGY

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

Cell shape dynamics during the staphylococcal cell cycle

(2015) João M. Monteiro et al.   Nature Communications

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

Functional Hierarchy of Redundant Actin Assembly Factors Revealed by Fine-Grained Registration of Intrinsic Image Fluctuations

(2015) Kwonmoo Lee et al.   Cell Systems

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration

(2014) Danfeng Cai et al.   CELL

Quantitative Assessment of the Relationship Between Cellular Morphodynamics and Signaling Events by Stochastic Analysis of Fluorescent Images

(2014) Giuseppe Maulucci et al.   MICROSCOPY AND MICROANALYSIS

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Motility efficiency and spatiotemporal synchronization in non-metastatic vs. metastatic breast cancer cells

(2013) Thomas M. Hermans et al.   Integrative Biology

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes

(2013) Zheng Yin et al.   NATURE CELL BIOLOGY

Traveling waves in actin dynamics and cell motility

(2012) Jun Allard et al.   CURRENT OPINION IN CELL BIOLOGY

Membrane waves driven by forces from actin filaments

(2012) Azam Gholami et al.   NEW JOURNAL OF PHYSICS

Regimes of wave type patterning driven by refractory actin feedback: transition from static polarization to dynamic wave behaviour

(2012) W R Holmes et al.   PHYSICAL BIOLOGY

Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

(2011) Eugene Tkachenko et al.   NATURE CELL BIOLOGY

Propagating Cell-Membrane Waves Driven by Curved Activators of Actin Polymerization

(2011) Barak Peleg et al.   PLoS One

Modeling of Protrusion Phenotypes Driven by the Actin-Membrane Interaction

(2010) Mihaela Enculescu et al.   BIOPHYSICAL JOURNAL

Automated characterization of cell shape changes during amoeboid motility by skeletonization

(2010) Yuan Xiong et al.   BMC Systems Biology

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Analysis of cell movement by simultaneous quantification of local membrane displacement and fluorescent intensities using Quimp2

(2009) Leonard Bosgraaf et al.   CELL MOTILITY AND THE CYTOSKELETON

Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells

(2008) Karen K. Hirschi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cell Shape and Negative Links in Regulatory Motifs Together Control Spatial Information Flow in Signaling Networks

(2008) Susana R. Neves et al.   CELL

Fluctuations of intracellular forces during cell protrusion

(2008) Lin Ji et al.   NATURE CELL BIOLOGY

Dynamic regimes and bifurcations in a model of actin-based motility

(2008) Mihaela Enculescu et al.   PHYSICAL REVIEW E

Ordered Patterns of Cell Shape and Orientational Correlation during Spontaneous Cell Migration

(2008) Yusuke T. Maeda et al.   PLoS One

A review on Hilbert-Huang transform: Method and its applications to geophysical studies

(2008) Norden E. Huang et al.   REVIEWS OF GEOPHYSICS

Quantification of Local Morphodynamics and Local GTPase Activity by Edge Evolution Tracking

(2008) Yuki Tsukada et al.   PLoS Computational Biology

Cell Shape Dynamics in Escherichia coli

(2007) Galina Reshes et al.   BIOPHYSICAL JOURNAL