Journal
NATIONAL SCIENCE REVIEW
Volume 7, Issue 5, Pages 835-837Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nsr/nwaa033
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Funding
- R&D Program of China [2018YFC2000100, 2017YFC1001302]
- CAS Strategic Priority Research Program [XDB32060000]
- National Natural Science Foundation of China [31871502, 31522037]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX05]
- Shanghai City Committee of science and technology project [18411953700, 18JC1410100]
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RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro. In this perspective, we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macular degeneration.
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