Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

(2021) Claire A Butler et al.   JOURNAL OF NEUROCHEMISTRY

Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead

(2021) Ben Cristofori-Armstrong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia: The Missing Link to Decipher and Therapeutically Control MS Progression?

(2021) Anastasia Geladaris et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia–Reperfusion Injury

(2021) Meredith A. Redd et al.   CIRCULATION

Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis

(2020) Jing-Jing Wang et al.   Nature Communications

A reference map of the human binary protein interactome

(2020) Katja Luck et al.   NATURE

Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)

(2020) Mirre De Bondt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The roles of astrocytic phagocytosis in maintaining homeostasis of brains

(2020) Se Young Lee et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Acid-sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis

(2019) Nana Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CRAC channel regulation of innate immune cells in health and disease

(2019) Regina A. Clemens et al.   CELL CALCIUM

Modulation of acid sensing ion channel dependent protonergic neurotransmission at the mouse calyx of Held

(2019) Carlota González-Inchauspe et al.   NEUROSCIENCE

Human astrocytes in the diseased brain

(2018) Elena Dossi et al.   BRAIN RESEARCH BULLETIN

Ion channelopathies of the immune system

(2018) Martin Vaeth et al.   CURRENT OPINION IN IMMUNOLOGY

CD18-mediated adhesion is required for the induction of a proinflammatory phenotype in lung epithelial cells by mononuclear cell-derived extracellular vesicles

(2018) Tommaso Neri et al.   EXPERIMENTAL CELL RESEARCH

Neutrophil heterogeneity: Bona fide subsets or polarization states?

(2018) Justin F. Deniset et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain

(2018) Robert A. Hill et al.   NATURE NEUROSCIENCE

The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

(2018) Luiz E. B. Savio et al.   Frontiers in Pharmacology

The Role of Astrocytes in Multiple Sclerosis

(2018) Gerald Ponath et al.   Frontiers in Immunology

Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes

(2018) Timothy Lynagh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

(2018) Wiebke Nadolni et al.   Cells

Immune cells and CNS physiology: Microglia and beyond

(2018) Geoffrey T. Norris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

(2017) Zhi-hang Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

(2017) Hideo Hagihara et al.   NEUROPSYCHOPHARMACOLOGY

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

(2017) Irène R. Chassagnon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells

(2017) Yu Wu et al.   TUMOR BIOLOGY

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

(2017) Eugene Y. Chiang et al.   Nature Communications

Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3

(2017) Yuemin Tian et al.   Scientific Reports

Acidosis differently modulates the inflammatory program in monocytes and macrophages

(2016) Anne Riemann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Spinal Cord Has an Intrinsic System for the Control of pH

(2016) Elham Jalalvand et al.   CURRENT BIOLOGY

Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases

(2016) Israel Hanukoglu et al.   GENE

Blood–brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice

(2016) Alexis M Stranahan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

A Review of the Mechanisms of Blood-Brain Barrier Permeability by Tissue-Type Plasminogen Activator Treatment for Cerebral Ischemia

(2016) Yasuhiro Suzuki et al.   Frontiers in Cellular Neuroscience

Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Chronic Epileptogenesis

(2016) Feng Yang et al.   Scientific Reports

ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease

(2016) Daniel Komnig et al.   PLoS One

DAMPs as mediators of sterile inflammation in aging-related pathologies

(2015) Noa Feldman et al.   AGEING RESEARCH REVIEWS

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

(2015) Claudia A. McCarthy et al.   NEUROPHARMACOLOGY

Genetic exploration of the role of acid-sensing ion channels

(2015) Shing-Hong Lin et al.   NEUROPHARMACOLOGY

Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

(2015) Yi-Zhi Wang et al.   eLife

Correction: Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions

(2015) Shannan Cao et al.   PLoS One

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function

(2014) Jordan W. Smoller et al.   BIOLOGICAL PSYCHIATRY

Knockdown of Acid-Sensing Ion Channel 1a (ASIC1a) Suppresses Disease Phenotype in SCA1 Mouse Model

(2014) Parminder J. S. Vig et al.   CEREBELLUM

Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia

(2014) Xiao-Wei Yu et al.   GLIA

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil contribution to spinal cord injury and repair

(2014) Virginie Neirinckx et al.   Journal of Neuroinflammation

Elevated Expression of Acid-Sensing Ion Channel 3 Inhibits Epilepsy via Activation of Interneurons

(2014) Qingqing Cao et al.   MOLECULAR NEUROBIOLOGY

Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride

(2013) Tarunya Arun et al.   BRAIN

Advanced Type 1 Diabetes is Associated with ASIC Alterations in Mouse Lower Thoracic Dorsal Root Ganglia Neurons

(2013) Beatrice Mihaela Radu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Extracellular acidosis modulates the endocytosis and maturation of macrophages

(2013) Xiaoling Kong et al.   CELLULAR IMMUNOLOGY

Oligodendrocyte-microglia cross-talk in the central nervous system

(2013) Laura Peferoen et al.   IMMUNOLOGY

Involvement of acid-sensing ion channel 1a in functions of cultured human retinal pigment epithelial cells

(2013) Jian Tan et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Molecular Mechanism of Constitutive Endocytosis of Acid-Sensing Ion Channel 1a and Its Protective Function in Acidosis-Induced Neuronal Death

(2013) W.-Z. Zeng et al.   JOURNAL OF NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Acid-sensing ion channels in pain and disease

(2013) John A. Wemmie et al.   NATURE REVIEWS NEUROSCIENCE

Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer Immunity

(2013) Aleksandra M. Dudek et al.   Frontiers in Immunology

Phagocytic and Oxidative Burst Activity of Neutrophils in Patients With Spinal Cord Injury

(2012) Selcen Kanyilmaz et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Blood-brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches

(2012) Nicola Marchi et al.   EPILEPSIA

Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood–brain barrier through paracellular transmigration and ERK activation

(2012) Divya Sagar et al.   Journal of Neuroinflammation

A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi

(2012) Geeta Ramesh et al.   Journal of Neuroinflammation

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Black mamba venom peptides target acid-sensing ion channels to abolish pain

(2012) Sylvie Diochot et al.   NATURE

Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions

(2012) A. Delaunay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Myeloperoxidase Exacerbates Secondary Injury by Generating Highly Reactive Oxygen Species and Mediating Neutrophil Recruitment in Experimental Spinal Cord Injury

(2012) Kensuke Kubota et al.   SPINE

Role of Acid-Sensing Ion Channel 1a in the Secondary Damage of Traumatic Spinal Cord Injury

(2011) Rong Hu et al.   ANNALS OF SURGERY

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

(2011) Sandra Vergo et al.   BRAIN

Trauma patients with the ‘triad of death’

(2011) Biswadev Mitra et al.   EMERGENCY MEDICINE JOURNAL

ASIC1a polymorphism is associated with temporal lobe epilepsy

(2011) Rui-juan Lv et al.   EPILEPSY RESEARCH

Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways

(2011) Yehoshua Enuka et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Acid-Sensing Ion Channels Contribute to the Effect of Acidosis on the Function of Dendritic Cells

(2011) J. Tong et al.   JOURNAL OF IMMUNOLOGY

Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death

(2011) T. W. Sherwood et al.   JOURNAL OF NEUROSCIENCE

Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis

(2011) B. Duan et al.   JOURNAL OF NEUROSCIENCE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Stopping Seizures With Carbon Dioxide

(2011) John W. Miller   Epilepsy Currents

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

Existence and distinction of acid-evoked currents in rat astrocytes

(2010) Chao Huang et al.   GLIA

Inhibition of acid-sensing ion channels in articular chondrocytes by amiloride attenuates articular cartilage destruction in rats with adjuvant arthritis

(2010) Feng-Lai Yuan et al.   INFLAMMATION RESEARCH

Identification of a Calcium Permeable Human Acid-sensing Ion Channel 1 Transcript Variant

(2010) Erin N. Hoagland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid-Sensing Ion Channels in Acidosis-Induced Injury of Human Brain Neurons

(2010) Minghua Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell Type-Specific Expression of Acid-Sensing Ion Channels in Hippocampal Interneurons

(2010) J. Y. Weng et al.   JOURNAL OF NEUROSCIENCE

Reduced gluconeogenesis and lactate clearance in Huntington's disease

(2010) Knud Josefsen et al.   NEUROBIOLOGY OF DISEASE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior

(2009) Adam E. Ziemann et al.   CELL

Acid-Sensing Ion Channel-1a in the Amygdala, a Novel Therapeutic Target in Depression-Related Behavior

(2009) M. W. Coryell et al.   JOURNAL OF NEUROSCIENCE

Characterization of acid-sensing ion channel expression in oligodendrocyte-lineage cells

(2008) Daniel H. Feldman et al.   GLIA

Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism

(2008) Hon Kit Wong et al.   HUMAN MOLECULAR GENETICS

Acid Sensing Ion Channels in Dorsal Spinal Cord Neurons

(2008) A. Baron et al.   JOURNAL OF NEUROSCIENCE

Seizure termination by acidosis depends on ASIC1a

(2008) Adam E Ziemann et al.   NATURE NEUROSCIENCE

Presynaptic Release Probability Is Increased in Hippocampal Neurons From ASIC1 Knockout Mice

(2007) Jun-Hyeong Cho et al.   JOURNAL OF NEUROPHYSIOLOGY

Increased lactate levels and reduced pH in postmortem brains of schizophrenics: Medication confounds

(2007) Nader D. Halim et al.   JOURNAL OF NEUROSCIENCE METHODS