Neutrophil heterogeneity: Bona fide subsets or polarization states?

Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells

(2018) Jung Hwan Kim et al.   NATURE IMMUNOLOGY

Splenic Ly6G high mature and Ly6G int immature neutrophils contribute to eradication of S. pneumoniae

(2017) Justin F. Deniset et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Visualizing the function and fate of neutrophils in sterile injury and repair

(2017) Jing Wang et al.   SCIENCE

A late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis

(2017) Min-Hyeok Kim et al.   Scientific Reports

CD13hi Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma

(2017) Jing Zhang et al.   OncoImmunology

Characterization of the CD177 interaction with the ANCA antigen proteinase 3

(2017) Uwe Jerke et al.   Scientific Reports

Aged neutrophils contribute to the first line of defense in the acute inflammatory response

(2016) B. Uhl et al.   BLOOD

Circadian regulation of human peripheral neutrophils

(2016) Krisztina Ella et al.   BRAIN BEHAVIOR AND IMMUNITY

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

(2016) Sunil Singhal et al.   CANCER CELL

Temporal neutrophil polarization following myocardial infarction

(2016) Yonggang Ma et al.   CARDIOVASCULAR RESEARCH

Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody

(2016) George A. Dominguez et al.   CLINICAL CANCER RESEARCH

Human neutrophils in the saga of cellular heterogeneity: insights and open questions

(2016) Patrizia Scapini et al.   IMMUNOLOGICAL REVIEWS

Distinct Oral Neutrophil Subsets Define Health and Periodontal Disease States

(2016) N. Fine et al.   JOURNAL OF DENTAL RESEARCH

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells

(2016) Alejo Chorny et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Subset of Neutrophils Expressing Markers of Antigen-Presenting Cells in Human Visceral Leishmaniasis

(2016) Smriti Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

Phenotypic and functional characteristics of HLA-DR + neutrophils in Brazilians with cutaneous leishmaniasis

(2016) Richard E. Davis et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells

(2016) Katrin Moses et al.   SEMINARS IN IMMUNOLOGY

Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis

(2016) Silvia Guglietta et al.   Nature Communications

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion

(2016) Zuopeng Wu et al.   PLoS Genetics

Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs

(2016) Merav E. Shaul et al.   OncoImmunology

Low-Density Granulocytes Are Elevated in Mycobacterial Infection and Associated with the Severity of Tuberculosis

(2016) Yating Deng et al.   PLoS One

Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans

(2015) S. Massena et al.   BLOOD

Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in HypertensionNovelty and Significance

(2015) Kandarp H. Shah et al.   CIRCULATION RESEARCH

Increased expression of low density granulocytes in juvenile-onset systemic lupus erythematosus patients correlates with disease activity

(2015) A Midgley et al.   LUPUS

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

MET is required for the recruitment of anti-tumoural neutrophils

(2015) Veronica Finisguerra et al.   NATURE

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria

(2015) Bruno Coelho Rocha et al.   Cell Reports

Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus

(2015) Olena Kamenyeva et al.   PLoS Pathogens

Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype

(2015) Sanjeeb Shrestha et al.   OncoImmunology

Neutrophil-like low-density granulocytes are elevated in patients with moderate to severe persistent asthma

(2014) Jun Fu et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis

(2014) Thomas Condamine et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a Novel Neutrophil Population: Proangiogenic Granulocytes in Second-Trimester Human Decidua

(2014) Hagai Amsalem et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

(2014) Giuliana Magri et al.   NATURE IMMUNOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

High-dimensional analysis of the murine myeloid cell system

(2014) Burkhard Becher et al.   NATURE IMMUNOLOGY

Failure To Detect Functional Neutrophil B Helper Cells in the Human Spleen

(2014) Sietse Quirijn Nagelkerke et al.   PLoS One

Characterization of Neutrophil Subsets in Healthy Human Pregnancies

(2014) Aloysius Ssemaganda et al.   PLoS One

Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome

(2014) Charlotte Summers et al.   THORAX

Tissue-Infiltrating Neutrophils Constitute the Major In Vivo Source of Angiogenesis-Inducing MMP-9 in the Tumor Microenvironment

(2014) Elena I. Deryugina et al.   NEOPLASIA

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences

(2013) Janesh Pillay et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In Vitro

(2013) Amanda Welin et al.   PLoS One

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

(2013) María Isabel Cuartero et al.   STROKE

VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

(2012) G. Christoffersson et al.   BLOOD

Olfactomedin 4 Inhibits Cathepsin C-Mediated Protease Activities, Thereby Modulating Neutrophil Killing of Staphylococcus aureus and Escherichia coli in Mice

(2012) W. Liu et al.   JOURNAL OF IMMUNOLOGY

C/EBPβ Is Involved in the Amplification of Early Granulocyte Precursors during Candidemia-Induced “Emergency” Granulopoiesis

(2012) Sakiko Satake et al.   JOURNAL OF IMMUNOLOGY

Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils

(2012) Zvi G. Fridlender et al.   PLoS One

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Olfactomedin 4 defines a subset of human neutrophils

(2011) Stine N. Clemmensen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Diurnal variation of hematology parameters in healthy young males: The Bispebjerg study of diurnal variations

(2011) Henriette P. Sennels et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Regulating neutrophil apoptosis: new players enter the game

(2011) Véronique Witko-Sarsat et al.   TRENDS IN IMMUNOLOGY

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

(2010) Jadwiga Jablonska et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism of T Cell Tolerance Induced by Myeloid-Derived Suppressor Cells

(2010) S. Nagaraj et al.   JOURNAL OF IMMUNOLOGY

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Stabilized imaging of immune surveillance in the mouse lung

(2010) Mark R Looney et al.   NATURE METHODS

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse

(2008) Rebecca C. Furze et al.   FASEB JOURNAL

Neutrophil apoptosis and the resolution of infection

(2008) Adam D. Kennedy et al.   IMMUNOLOGIC RESEARCH

Constitutive neutrophil apoptosis: Mechanisms and regulation

(2007) Hongbo R. Luo et al.   AMERICAN JOURNAL OF HEMATOLOGY