Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms
Authors
Keywords
Methotrexate, Drug induced liver injury, Psoriasis, Rheumatoid arthritis
Journal
TOXICOLOGY
Volume 458, Issue -, Pages 152840
Publisher
Elsevier BV
Online
2021-06-25
DOI
10.1016/j.tox.2021.152840
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Boldine treatment protects acetaminophen‐induced liver inflammation and acute hepatic necrosis in mice
- (2021) Devaraj Ezhilarasan et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Nrf2: a main responsive element in cells to mycotoxin-induced toxicity
- (2021) Marta Justyna Kozieł et al. ARCHIVES OF TOXICOLOGY
- Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines
- (2021) Harshad Devarbhavi et al. Hepatology International
- Methotrexate and its mechanisms of action in inflammatory arthritis
- (2020) Bruce N. Cronstein et al. Nature Reviews Rheumatology
- β-Sitosterol attenuates carbon tetrachloride–induced oxidative stress and chronic liver injury in rats
- (2020) Ezhilarasan Devaraj et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells
- (2020) Hany Elsawy et al. BIOSCIENCE REPORTS
- Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- (2020) Omnia E. Hussein et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers
- (2020) Przemysław Koźmiński et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- STAT3: A key regulator in liver fibrosis
- (2020) Jie Zhao et al. Annals of Hepatology
- Ginkgo biloba Extract Protects against Methotrexate-Induced Hepatotoxicity: A Computational and Pharmacological Approach
- (2020) Lina Tariq Al Kury et al. MOLECULES
- MicroRNA interplay between hepatic stellate cell quiescence and activation
- (2020) Devaraj Ezhilarasan EUROPEAN JOURNAL OF PHARMACOLOGY
- Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells
- (2020) Devaraj Ezhilarasan EXPERIMENTAL BIOLOGY AND MEDICINE
- Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity
- (2020) Mehdi Goudarzi et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis
- (2020) Iman O. Sherif et al. DRUG AND CHEMICAL TOXICOLOGY
- Protective effects of Glycyrrhiza glabra supplementation against methotrexate-induced hepato-renal damage in rats: An experimental approach
- (2020) Prerna Chauhan et al. JOURNAL OF ETHNOPHARMACOLOGY
- An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
- (2020) Sarmistha Saha et al. MOLECULES
- Acetaminophen Hepatotoxicity
- (2019) Anup Ramachandran et al. SEMINARS IN LIVER DISEASE
- Drug-Induced Acute-on-Chronic Liver Failure in Asian Patients
- (2019) Harshad Devarbhavi et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Low-dose methotrexate toxicity
- (2019) Kevin Pivovarov et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long‐term follow‐up of predictors, surveillance, and outcome in clinical practice
- (2019) Johanna Karlsson Sundbaum et al. International Journal of Rheumatic Diseases
- Drug-induced liver injury
- (2019) Raul J. Andrade et al. Nature Reviews Disease Primers
- Dapsone-induced hepatic complications: it’s time to think beyond methemoglobinemia
- (2019) Devaraj Ezhilarasan DRUG AND CHEMICAL TOXICOLOGY
- Liver Abnormalities in Patients with Psoriatic Arthritis
- (2019) Rattapol Pakchotanon et al. JOURNAL OF RHEUMATOLOGY
- Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats
- (2019) Reihaneh Ebrahimi et al. DARU-Journal of Pharmaceutical Sciences
- Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats
- (2019) Ayman M. Mahmoud et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein
- (2019) Kenji Ikemura et al. Scientific Reports
- Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease
- (2018) Maja Thiele et al. GASTROENTEROLOGY
- Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets
- (2018) Devaraj Ezhilarasan et al. Hepatobiliary & Pancreatic Diseases International
- Psoriatic patients with chronic viral hepatitis do not have an increased risk of liver cirrhosis despite long-term methotrexate use: real-world data from a nationwide cohort study in Taiwan.
- (2018) Kuo-Tung Tang et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study
- (2018) Jun Hakamata et al. Modern Rheumatology
- Antioxidant response elements: Discovery, classes, regulation and potential applications
- (2018) Azhwar Raghunath et al. Redox Biology
- Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective
- (2018) Devaraj Ezhilarasan Arab Journal of Gastroenterology
- Methotrexate mechanism in treatment of rheumatoid arthritis
- (2018) Benjamin Friedman et al. JOINT BONE SPINE
- Burden of Liver Diseases in the World
- (2018) Sumeet K. Asrani et al. JOURNAL OF HEPATOLOGY
- Non-alcoholic steatohepatitis-like pattern in liver biopsy of rheumatoid arthritis patients with persistent transaminitis during low-dose methotrexate treatment
- (2018) Shunsuke Mori et al. PLoS One
- Roles of the immune system in cancer: from tumor initiation to metastatic progression
- (2018) Hugo Gonzalez et al. GENES & DEVELOPMENT
- Association between cumulative methotrexate dose, non-invasive scoring system and hepatic fibrosis detected by Fibroscan in rheumatoid arthritis patients receiving methotrexate
- (2018) Ratchaya Lertnawapan et al. International Journal of Rheumatic Diseases
- Validation of the Fibrosis-4 (FIB-4) index in the diagnosis of liver disease of rheumatoid arthritis patients treated with methotrexate
- (2018) Masayuki Miyata et al. Modern Rheumatology
- Drug-induced liver injury: recent advances in diagnosis and risk assessment
- (2017) Gerd A Kullak-Ublick et al. GUT
- Drug-induced acute liver failure in children and adults: Results of a single-centre study of 128 patients
- (2017) Harshad Devarbhavi et al. LIVER INTERNATIONAL
- Hepatoprotective effect of sitagliptin against methotrexate induced liver toxicity
- (2017) Hany M. Abo-Haded et al. PLoS One
- The Australasian Psoriasis Collaboration view on methotrexate for psoriasis in the Australasian setting
- (2016) Marius Rademaker et al. AUSTRALASIAN JOURNAL OF DERMATOLOGY
- Mechanism of action of methotrexate in rheumatoid arthritis and the search for biomarkers
- (2016) Philip M. Brown et al. Nature Reviews Rheumatology
- Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: impact of oxidative stress, inflammation and apoptosis
- (2016) Mina T Kelleni et al. TOXICOLOGY MECHANISMS AND METHODS
- Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B
- (2016) Kuo-Tung Tang et al. Scientific Reports
- Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis
- (2016) Tatsuhiro Yamamoto et al. Scientific Reports
- Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: impact of oxidative stress, inflammation and apoptosis
- (2016) Mina T Kelleni et al. TOXICOLOGY MECHANISMS AND METHODS
- Methotrexate-related Primary Hepatic Lymphoma in a Patient with Rheumatoid Arthritis
- (2015) Koichiro Miyagawa et al. INTERNAL MEDICINE
- Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction
- (2015) Erkan Cure et al. Journal of Cancer Research and Therapeutics
- Methotrexate polyglutamates as a potential marker of adherence to long-term therapy in children with juvenile idiopathic arthritis and juvenile dermatomyositis: an observational, cross-sectional study
- (2015) Ahmed F. Hawwa et al. ARTHRITIS RESEARCH & THERAPY
- Validity of noninvasive markers of methotrexate-induced hepatotoxicity: a retrospective cohort study
- (2014) C.L. Martyn-Simmons et al. BRITISH JOURNAL OF DERMATOLOGY
- Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
- (2014) Kamilia Ksouda et al. INDIAN JOURNAL OF PHARMACOLOGY
- Drug-Induced Liver Injury
- (2014) Michael D. Leise et al. MAYO CLINIC PROCEEDINGS
- Biomarkers for methotrexate-induced liver injury: Urinary protein profiling of psoriasis patients
- (2013) Rachel P.L. van Swelm et al. TOXICOLOGY LETTERS
- Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate
- (2012) Cristina Lucía Dávila-Fajardo et al. PHARMACOGENOMICS
- Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK
- (2011) Charles F. Spurlock et al. ARTHRITIS AND RHEUMATISM
- Protective role of taurine against genotoxic damage in mice treated with methotrexate and tamoxfine
- (2010) Sally S. Alam et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative
- (2008) K Visser et al. ANNALS OF THE RHEUMATIC DISEASES
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now