Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells

(2020) Hany Elsawy et al.   BIOSCIENCE REPORTS

Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity

(2020) Mozhdeh Roghani et al.   Drug Design Development and Therapy

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats

(2019) Mojtaba Kalantar et al.   Pharmacological Reports

Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats

(2018) Saeed Mehrzadi et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effect of thymoquinone, the main component of Nigella Sativa, against diazinon cardio-toxicity in rats

(2018) Gholam Hassan Danaei et al.   DRUG AND CHEMICAL TOXICOLOGY

Protective effects of α-bisabolol on altered hemodynamics, lipid peroxidation, and nonenzymatic antioxidants in isoproterenol-induced myocardial infarction: In vivo and in vitro evidences

(2018) Mohamed Fizur Nagoor Meeran et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts

(2018) Radhiga Thangaiyan et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Montelukast abrogates prednisolone-induced hepatic injury in rats: Modulation of mitochondrial dysfunction, oxidative/nitrosative stress, and apoptosis

(2018) Islam Ibrahim Hegab et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Biological functions of epicatechin: Plant cell to human cell health

(2018) Monika Prakash et al.   Journal of Functional Foods

Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines

(2017) Amani Mahbub et al.   Oncotarget

Hepatoprotective effect of sitagliptin against methotrexate induced liver toxicity

(2017) Hany M. Abo-Haded et al.   PLoS One

Methotrexate for Inflammatory Bowel Diseases - New Developments

(2016) Hans H. Herfarth   DIGESTIVE DISEASES

Preventing and Managing Toxicities of High-Dose Methotrexate

(2016) S. C. Howard et al.   ONCOLOGIST

Potential protective effect of etanercept and aminoguanidine in methotrexate-induced hepatotoxicity and nephrotoxicity in rats

(2015) Heba M. Hafez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines

(2015) A A Mahbub et al.   Cell Death & Disease

Anti-Inflammatory Effects of Apigenin in Lipopolysaccharide-Induced Inflammatory in Acute Lung Injury by Suppressing COX-2 and NF-kB Pathway

(2014) Jing Wang et al.   INFLAMMATION

Protective effect of apigenin against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in albino rats

(2014) Fahad Ali et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation

(2013) S. Dalaklioglu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways

(2013) Sudeshna Mukherjee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis

(2013) Nemat Ali et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity

(2013) Juan Yang et al.   Food & Function

Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells

(2012) Yong Yang et al.   CELL BIOCHEMISTRY AND FUNCTION

Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats

(2012) Xiao-Li He et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells

(2012) Eun-Ju Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells

(2012) E. Ramesh et al.   FOOD AND CHEMICAL TOXICOLOGY

The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation

(2012) Vasilis P. Androutsopoulos et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin attenuates lindane induced oxidative stress in wistar rats

(2012) Viswanadha Vijaya Padma et al.   MOLECULAR BIOLOGY REPORTS

Apigenin and its impact on gastrointestinal cancers

(2012) Émilie C. Lefort et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-proliferative effect of Flos Albiziae flavonoids on the human gastric cancer SGC-7901 cell line

(2012) JIANMEI YUAN et al.   Experimental and Therapeutic Medicine

Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells

(2011) Davide Staedler et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C. Part 9: Reference procedure for the measurement of catalytic concentration of alkaline phosphatase

(2011) Gerhard Schumann et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: Involvement of cell line-specific apoptotic mechanisms

(2011) Prema S. Rao et al.   INTERNATIONAL JOURNAL OF CANCER

Selective apoptotic effects of piceatannol and myricetin in human cancer cells

(2011) Paloma Morales et al.   JOURNAL OF APPLIED TOXICOLOGY

Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice

(2010) Zhuo Fu et al.   BRITISH JOURNAL OF NUTRITION

Anticlastogenic effect of apigenin in human lymphocytes treated with ethinylestradiol

(2010) Yasir Hasan Siddique et al.   FITOTERAPIA

Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells

(2010) Ok-Hwa Kang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors

(2009) E. B. Golden et al.   BLOOD

Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction

(2009) Tae Young Kim et al.   BRITISH JOURNAL OF HAEMATOLOGY

Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress

(2009) Bi-hui Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats

(2009) M.I. Yousef et al.   FOOD AND CHEMICAL TOXICOLOGY

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

(2009) Ana García-Lafuente et al.   INFLAMMATION RESEARCH

Haematological and serum biochemical reference values for apparently healthy working horses in Pakistan

(2009) Joy C. Pritchard et al.   RESEARCH IN VETERINARY SCIENCE

Role of Grape Seed Extract on Methotrexate Induced Oxidative Stress in Rat Liver

(2008) Aysun Çetin et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells

(2008) Yasir Hasan Siddique et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells

(2008) Cheng-Yun Jin et al.   TOXICOLOGY IN VITRO

Antigenotoxic effect of apigenin against anti-cancerous drugs

(2007) Yasir Hasan Siddique et al.   TOXICOLOGY IN VITRO