Strategies for durable β cell replacement in type 1 diabetes

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis

(2021) MacKenzie D. Williams et al.   DIABETES

Multiple clinically relevant immunotherapies prolong the function of microencapsulated porcine islet xenografts in diabetic NOD mice without the use of anti‐CD154 mAb

(2020) Susan A. Safley et al.   XENOTRANSPLANTATION

Engineered Biomaterials for Enhanced Function of Insulin‐Secreting β‐Cell Organoids

(2020) Michael D. Hunckler et al.   ADVANCED FUNCTIONAL MATERIALS

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion

(2020) Aharon Helman et al.   Cell Metabolism

Slowed Metabolic Decline after One Year of Oral Insulin Treatment among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 and TrialNet Oral Insulin Prevention Trials

(2020) Jay M. Sosenko et al.   DIABETES

Current status of porcine islet xenotransplantation

(2020) Taylor M. Coe et al.   Current Opinion in Organ Transplantation

Engineering designer beta cells with a CRISPR-Cas9 conjugation platform

(2020) Donghyun Lim et al.   Nature Communications

In vitro platform establishes antigen-specific CD8+ T cell cytotoxicity to encapsulated cells via indirect antigen recognition

(2020) Ying Li et al.   BIOMATERIALS

Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes

(2020) Laura M. Jacobsen et al.   Diabetes Technology & Therapeutics

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

(2020) Punn Augsornworawat et al.   Cell Reports

Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients

(2020) Rosaura Casas et al.   Frontiers in Immunology

Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival

(2020) María M. Coronel et al.   Science Advances

Particulate‐Based Single‐Dose Local Immunosuppressive Regimen for Inducing Tolerogenic Dendritic Cells in Xenogeneic Islet Transplantation

(2020) Shiva Pathak et al.   Advanced Healthcare Materials

A scalable device-less biomaterial approach for subcutaneous islet transplantation

(2020) Alexander E. Vlahos et al.   BIOMATERIALS

State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018

(2019) Nicole C. Foster et al.   Diabetes Technology & Therapeutics

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

A Century of Diabetes Technology: Signals, Models, and Artificial Pancreas Control

(2019) Boris Kovatchev   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Engineering immunomodulatory biomaterials for type 1 diabetes

(2019) C. L. Stabler et al.   Nature Reviews Materials

Oxygen generating biomaterial improves the function and efficacy of beta cells within a macroencapsulation device

(2019) M.M. Coronel et al.   BIOMATERIALS

Islet‐Immune Interactions in Type 1 Diabetes: The Nexus of Beta Cell Destruction

(2019) Leeana Peters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

VEGF-A and blood vessels: a beta cell perspective

(2019) Willem Staels et al.   DIABETOLOGIA

Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model

(2019) Cherie L. Stabler et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

The Role of the Islet Niche on Beta Cell Structure and Function

(2019) Eckhard Lammert et al.   JOURNAL OF MOLECULAR BIOLOGY

Transplanting organs from pigs to humans

(2019) Megan Sykes et al.   Science Immunology

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

(2019) Juan R. Alvarez-Dominguez et al.   Cell Stem Cell

Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation

(2019) Hitomi Matsunari et al.   Stem Cell Reports

In-situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo

(2018) Clarissa Hernandez Stephens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

(2018) Per-Ola Carlsson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform

(2018) Joseph Candiello et al.   BIOMATERIALS

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

Clinical islet transplantation

(2018) Andrew R. Pepper et al.   Current Opinion in Organ Transplantation

Improved Health-Related Quality of Life in a Phase 3 Islet Transplantation Trial in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2018) Eric D. Foster et al.   DIABETES CARE

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

(2018) Devon M. Headen et al.   NATURE MATERIALS

Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells

(2018) Jon Odorico et al.   TRANSPLANTATION

Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes

(2018) Kevin C. Osum et al.   Scientific Reports

The challenge of modulating β-cell autoimmunity in type 1 diabetes

(2018) Mark A Atkinson et al.   Lancet Diabetes & Endocrinology

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

mTOR Inhibition & Clinical Transplantation

(2017) Thierry Berney et al.   TRANSPLANTATION

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

(2017) Andrew R. Pepper et al.   Stem Cell Reports

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant

(2017) Gaetano Faleo et al.   Stem Cell Reports

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes

(2017) Wen-I Yeh et al.   Frontiers in Immunology

Direct and indirect allograft recognition

(2016) Christine M. Lin et al.   Current Opinion in Organ Transplantation

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Design principles for therapeutic angiogenic materials

(2016) Priscilla S. Briquez et al.   Nature Reviews Materials

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo

(2015) Alan D. Agulnick et al.   Stem Cells Translational Medicine

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

(2013) David W. Scharp et al.   ADVANCED DRUG DELIVERY REVIEWS

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

(2008) Todd M. Brusko et al.   IMMUNOLOGICAL REVIEWS