Particulate‐Based Single‐Dose Local Immunosuppressive Regimen for Inducing Tolerogenic Dendritic Cells in Xenogeneic Islet Transplantation

Low Dose IL-2 Combined with Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Tregs and Prolonged Human Islet-allograft Survival in Humanized Mice

(2020) Min Hu et al.   DIABETES

Single-dose intraperitoneal delivery of FK506-encapsulated polymeric microspheres for the alleviation of murine colitis

(2020) Shiva Pathak et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Tolerogenic Dendritic Cells: The Pearl of Immunotherapy in Organ Transplantation

(2020) Quan Zhuang et al.   Frontiers in Immunology

Immunoisolation of pancreatic islets via thin-layer surface modification

(2019) Shiva Pathak et al.   JOURNAL OF CONTROLLED RELEASE

Treg-mediated prolonged survival of skin allografts without immunosuppression

(2019) Nina Pilat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory Nanosystems

(2019) Xiangru Feng et al.   Advanced Science

Engineering transferrable microvascular meshes for subcutaneous islet transplantation

(2019) Wei Song et al.   Nature Communications

Pancreatic islets engineered with a FasL protein induce systemic tolerance at the induction phase that evolves into long‐term graft‐localized immune privilege

(2019) Kyle B. Woodward et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Rejection of xenogeneic porcine islets in humanized mice is characterized by graft‐infiltrating Th17 cells and activated B cells

(2019) Frances T. Lee et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Inflammation-triggered local drug release ameliorates colitis by inhibiting dendritic cell migration and Th1/Th17 differentiation

(2019) Shobha Regmi et al.   JOURNAL OF CONTROLLED RELEASE

Polymeric microsphere-facilitated site-specific delivery of quercetin prevents senescence of pancreatic islets in vivo and improves transplantation outcomes in mouse model of diabetes

(2018) Shiva Pathak et al.   Acta Biomaterialia

Clinical islet transplantation

(2018) Andrew R. Pepper et al.   Current Opinion in Organ Transplantation

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

(2018) Devon M. Headen et al.   NATURE MATERIALS

Islet transplantation in type 1 diabetes: moving forward

(2018) Shareen Forbes et al.   Lancet Diabetes & Endocrinology

Engineered islet cell clusters transplanted into subcutaneous space are superior to pancreatic islets in diabetes

(2017) Shiva Pathak et al.   FASEB JOURNAL

Hybrid Congregation of Islet Single Cells and Curcumin-Loaded Polymeric Microspheres as an Interventional Strategy to Overcome Apoptosis Associated with Pancreatic Islets Transplantation

(2016) Shiva Pathak et al.   ACS Applied Materials & Interfaces

Combination strategy of multi-layered surface camouflage using hyperbranched polyethylene glycol and immunosuppressive drugs for the prevention of immune reactions against transplanted porcine islets

(2016) Muhammad R. Haque et al.   BIOMATERIALS

Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-co-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method

(2016) Shiva Pathak et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival

(2015) I. Batal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Local Co-Delivery of Pancreatic Islets and Liposomal Clodronate Using Injectable Hydrogel to Prevent Acute Immune Reactions in a Type 1 Diabetes

(2014) Muhammad R. Haque et al.   PHARMACEUTICAL RESEARCH

Clinical Porcine Islet Xenotransplantation Under Comprehensive Regulation

(2014) S. Matsumoto et al.   TRANSPLANTATION PROCEEDINGS

Poly(lactic-co-glycolic) Acid-Controlled-Release Systems: Experimental and Modeling Insights

(2013) Daniel J. Hines et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Endogenous Expansion of Regulatory T Cells Leads to Long-Term Islet Graft Survival in Diabetic NOD Mice

(2012) Q. Shi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Advancing islet transplantation: from engraftment to the immune response

(2011) R. F. Gibly et al.   DIABETOLOGIA

Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T Cells in Mice

(2011) E. S. Yolcu et al.   JOURNAL OF IMMUNOLOGY

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

(2011) Hirenkumar K. Makadia et al.   Polymers

An update on regulatory T cells in transplant tolerance and rejection

(2010) Xian Chang Li et al.   Nature Reviews Nephrology

Mycophenolate Mofetil and Calcineurin-Inhibitor Reduction: Recent Progress

(2009) Josep M. Grinyó et al.   AMERICAN JOURNAL OF TRANSPLANTATION

In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses

(2009) Jingjing Wu et al.   TRANSPLANTATION

Mechanism of cellular rejection in transplantation

(2008) Elizabeth Ingulli   PEDIATRIC NEPHROLOGY