Article
Clinical Neurology
Lorane Bechet, Philippe Cabre, Harold Merle
Summary: The thickness of Bruch membrane opening minimum rim width (BMO) is significantly reduced in patients with neuromyelitis optica (NMO) and multiple sclerosis (MS), and this reduction is correlated with visual function. BMO shows improved ability compared to retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) in detecting infraclinical impairment in NMO patients without a history of optic neuropathy.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Alberto Dominguez-Vicent, Maria Nilsson, Rune Brautaset, Abinaya Priya Venkataraman
Summary: This study evaluated the similarities between horizontal and vertical Optical Coherence Tomography (OCT) scans in measuring individual retinal layer thickness. The results showed that the differences in thickness measurements between the two scans were smaller than the instrument's resolution in all groups. The differences in measurements varied among different layers and sectors, suggesting the importance of consistent scan direction in follow-up OCT measurements and clinical studies.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Aurelian Mihai Ghita, Daniela Adriana Iliescu, Ana Cristina Ghita, Larisa Adriana Ilie, Alexandru Otobic
Summary: The aim of this review is to analyze the correlations between changes in the ganglion cell complex (GCC) and the retinal nerve fiber layer (RNFL) on optical coherence tomography in different possible situations, especially in eyes with glaucoma. GCC analysis, particularly the thickness of the infero and inferotemporal GCC layers, is a more sensitive examination than circumpapillary RNFL in early stages of glaucoma. In advanced stages, evaluating the visual field is more useful for monitoring glaucoma progression.
Article
Multidisciplinary Sciences
Sooyeon Choe, Mirinae Jang, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
Summary: This study investigated the diagnostic utility of three-dimensional neuroretinal rim thickness (3D-NRRT) in distinguishing patients with superior segmental optic nerve hypoplasia (SSOH) from normal-tension glaucoma (NTG). The results showed that 3D-NRRT can be useful in differentiating SSOH from NTG, particularly in certain clock-hour sectors. However, retinal nerve fiber layer thickness (RNFLT) may be more appropriate for distinguishing the two conditions in other sectors.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ji-Ah Kim, Eun Ji Lee, Tae-Woo Kim, Se Joon Woo
Summary: This study found differences in the topographic morphology of the optic nerve head between eyes with normal-tension glaucoma and central retinal artery occlusion, suggesting different mechanisms of optic nerve head damage in these two conditions.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Nimesh B. Patel, Louvenia Carter-Dawson, Laura J. Frishman
Summary: This study found that the optic nerve head's response to transient changes in intraocular pressure is associated with features of the optic nerve head and surrounding tissues. The neural rim properties at baseline and the extent of axial elongation are associated with the severity of glaucomatous loss in the nonhuman primate model.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Medicine, General & Internal
Muesluem Toptan, Ali Simsek
Summary: This study compared the retinal nerve fiber layer (RNFL) thickness and choroidal thickness in patients with exfoliation syndrome (XFS) and exfoliative glaucoma (XFG) to healthy volunteers. The results showed that both RNFL and macular choroidal thickness were significantly lower in the XFG and XFS groups compared to the control group. There was no significant difference between the XFS and control groups. The difference in thickness between patients diagnosed 6-10 years ago and those diagnosed 1-5 years ago was not statistically significant.
Article
Multidisciplinary Sciences
Andrew K. C. Lam, H. C. Lai, Y. K. Sung, W. H. Lam, C. M. Tiu
Summary: This study investigated the success rate of NRR segmentation in myopic eyes using Cirrus built-in software and determined the number of acquisitions required to identify NRR thinning. The results showed that there were segmentation errors in some scans, and these errors occurred more frequently in the inferior-temporal and superior meridians. Manual inspection of Cirrus segmentation lines is necessary for accurate NRR thickness measurement.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Yuwen Wen, Yingting Zhu, Yehong Zhuo
Summary: This study found that in pediatric patients with glaucoma, the thickness of the retinal nerve fiber layer (RNFL) showed varying degrees of thinning in eight different quadrants, contributing to a better understanding of the neuropathic mechanisms of childhood glaucoma.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Geng Wang, Miaoru Zhen, Shasha Liu, Kunliang Qiu, Cui Liu, Ji Wang, Mingzhi Zhang
Summary: This study compared the diagnostic classification of Bruch's membrane opening-minimum rim width (BMO-MRW) and RNFL thickness in normal myopic subjects, finding that RNFL thickness classified a significantly higher proportion of eyes as outside normal limits/borderline in at least 1 quadrant. The low myopic group had a significantly lower proportion of eyes classified as outside normal limits/borderline compared to moderate and high myopic groups.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Hayati Yilmaz, Mehmet Talay Koylu, Bagim Aycin Cakir, Murat Kucukevcilioglu, Ali Hakan Durukan, Atilla Bayer, Fatih Mehmet Mutlu
Summary: This study investigated the retinal nerve fiber layer thickness (RNFLT) in patients with uveitis and found that it was significantly higher compared to controls. Active uveitis was associated with thicker RNFLT, while anterior uveitis was associated with thinner RNFLT.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Riccardo Cheloni, Simon D. Dewsbery, Jonathan Denniss
Summary: The study introduced a novel method for extracting en face slab images (SMAS) to detect glaucomatous abnormalities. Comparing with alternative methods, SMAS showed better performance in detecting glaucoma defects, achieving greater detection of reflectance abnormalities without increasing surrogate false positives.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Francois Boussion, Damien Guindolet, Romain Deschamps, Cedric Lamirel, Catherine Vignal-Clermont
Summary: The global peripapillary retinal nerve fiber layer thickness (pRNFL)/Bruch membrane opening-minimum rim width (BMO-MRW) ratio is an objective and effective parameter to distinguish glaucomatous optic neuropathies (GONs) from nonGONs (NGONs). This study evaluated the diagnostic capability of the pRNFL/BMO-MRW ratio in differentiating GONs from NGONs. Results showed that the global pRNFL/BMO-MRW ratio had the highest accuracy in distinguishing between GONs and NGONs, with a cutoff value of 0.34. The ratio was associated with the severity of visual field-defect in GONs and NGONs. These findings highlight the importance of pRNFL/BMO-MRW ratio in diagnosing and differentiating glaucomatous optic neuropathies.
JOURNAL OF GLAUCOMA
(2023)
Article
Ophthalmology
Yumi Lee, Kyung-Ah Park, Sei Yeul Oh
Summary: The study found that in patients with NAION, the peripapillary retinal nerve fiber layer and macular outer nuclear layer were thicker within 2 months of onset compared to controls. However, within 2-5 months, there was thinning in the peripapillary retinal nerve fiber layer, macular retinal nerve fiber layer, and ganglion cell layer and inner plexiform layer, which was associated with final visual field outcomes.
Article
Engineering, Biomedical
Hina Raja, Taimur Hassan, Muhammad Usman Akram, Naoufel Werghi
Summary: This study introduces a novel strategy focusing on RGC atrophy for screening and grading the severity of glaucomatous pathologies. The proposed framework utilizes a hybrid convolutional network to extract specific regions in the retina, allowing for quantitative screening of glaucomatous subjects. The performance of this framework is rigorously tested and clinically validated, achieving high accuracy in diagnosing and grading glaucomatous progression.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Ophthalmology
Charumathi Sabanayagam, Rehena Sultana, Riswana Banu, Tyler Rim, Yih Chung Tham, Sunita Mohan, Miao Li Chee, Ya Xing Wang, Vinay Nangia, Kohta Fujiwara, E. Shyong Tai, Su Jeong Song, Mukharram M. Bikbov, Rajiv Raman, Ching Yu Cheng, Tien Yin Wong, Jost B. Jonas
Summary: This study found an inverse association between BMI and obesity with diabetic retinopathy in Asian adults with diabetes. Overweight did not show a significant association with diabetic retinopathy. Further longitudinal studies are needed to confirm these findings.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Qing Zhang, Liang Xu, Liang Zhao, Rahul A. Jonas, Ya Xing Wang, Jost B. Jonas
Summary: The distribution and associations of the circumpapillary retinal nerve fibre layer thickness profile, characterized as peak height and peak position, in healthy eyes were investigated in this study. The peak RNFLT was thickest at Peak(IT), followed by Peak(ST) and Peak(SN), and was found to decrease with longer axial length, older age, female gender, and larger parapapillary gamma zone and beta zone width. The position of temporal peaks was influenced by gender, axial length, and BMO diameter.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Nan Zhou, Xiaolin Xu, Yueming Liu, Yaxing Wang, Wenbin Wei
Summary: The modified intravitreal injection regimen of MTX is effective in inducing clinical remission of intraocular involvement in PCNSL patients with few complications. Further studies are needed to determine if this approach extends life expectancy.
Article
Ophthalmology
Mirinae Jang, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Summary: Seasonal variation in optic disc hemorrhage (DH) was investigated through a retrospective observational study, revealing a higher incidence in winter and a significant association with temperature and intraocular pressure (IOP).
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Yong Woo Kim, Glen P. Sharpe, Donna M. Hutchison, Paul E. Rafuse, Lesya M. Shuba, Marcelo T. Nicolela, Jayme R. Vianna, Balwantray C. Chauhan
Summary: The impact of glaucoma severity on the rates of change in minimum rim width (MRW), peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell layer (GCL) thickness was studied. The study found that glaucoma patients had a faster rate of change in GCL thickness compared to healthy subjects, while there were no significant differences in the rates of change in MRW and RNFL. Age and visual field mean deviation (MD) also had some impact on the rates of change.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ahnul Ha, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: This study aimed to investigate the relationship between optic disc morphological changes during myopia progression and the development of retinal nerve fiber layer defect (RNFLD). The results showed that progressive optic disc tilt during myopia progression was associated with a higher risk of RNFLD development in children with large vertical cup-to-disc ratio (vCDR).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yun Jeong Lee, Seung Chan Lee, Seo Young Wy, Hoo Young Lee, Hyang Lim Lee, Woo Hyung Lee, Byung-Mo Oh, Jin Wook Jeoung
Summary: This study compared ocular manifestations, visual field patterns, and visual field test performance in traumatic brain injury (TBI) and stroke patients. The results showed that strabismus and cataract were the most common ocular manifestations in TBI patients, whereas cataract and strabismus were the most common in stroke patients. Additionally, both groups had visual field defects and unreliable visual field test performance.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sooyeon Choe, Ahnul Ha, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: This study aimed to develop a macular sector-wise decision tree model for predicting parafoveal scotoma in patients with early-stage glaucoma. By analyzing the results of relevant tests, the study found that macular ganglion cell-inner plexiform layer analysis can be a useful tool in determining the need for 10-2 tests.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Health Policy & Services
Kelley R. Davis, Sharon L. Norman, Bradley G. Olson, Shaban Demirel, Asma A. Taha
Summary: This quality improvement project aimed to evaluate the impact of an educational intervention to improve the quality of providers' recommendations and subsequent vaccination rates. The results showed that the quality of vaccine recommendations was improved after the intervention, but the vaccination rates did not increase. The study found that providers' delivery style is important for increasing vaccination rates.
JOURNAL OF PEDIATRIC HEALTH CARE
(2022)
Article
Ophthalmology
Sooyeon Choe, Ahnul Ha, Seulggie Choi, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: The purpose of this study was to determine the incidence of infantile cataract (IC) surgery and the risk of secondary glaucoma in the Korean population. A retrospective cohort study was conducted using the Korean National Health Claims database. The study found that the annual incidence of IC surgery ranged from 5.10 to 9.29 cases per 100,000 individuals, and the incidence rate of post-IC surgery glaucoma was 2.29 per 100 person-years. Factors such as intraocular lens implantation were found to reduce the risk of post-IC surgery glaucoma.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Sooyeon Choe, Mirinae Jang, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
Summary: The diagnostic abilities of Spectralis and Cirrus OCT for detecting RNFL defects in patients with PPG and EG were compared in this study. Both Spectralis and Cirrus OCT showed good diagnostic performance in detecting RNFL defects in PPG and EG patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sooyeon Choe, Young Kook Kim, Ki Ho Park, Hyuk Jin Choi, Jin Wook Jeoung
Summary: This study investigated the natural history of optic disc with physiologic large cup (PLC), as well as the risk factors for glaucoma conversion. The study identified higher VCDR, violation of the inferior superior nasal temporal neuroretinal rim thickness rule, presence of retinal arterial sclerosis, and lower total bilirubin level as factors associated with glaucoma development.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ahnul Ha, Sukkyu Sun, Young Kook Kim, Jin Wook Jeoung, Hee Chan Kim, Ki Ho Park
Summary: This study assessed the performance of deep-learning models in predicting conversion to normal-tension glaucoma, and found that the models showed good predictive ability.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rami Darwich, Faisal Jarrar, Mustafa Syed, Glen P. Sharpe, Balwantray C. Chauhan
Summary: Both spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) showed similar visualization of optic nerve head (ONH) structures, with a tendency for higher visualization rates with SS-OCT.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Akshay Govind, Shaban Demirel, Kristin Lee, Melissa Amundson, Richard Bryan Bell, Eric Dierks
Summary: This study aimed to identify predictors of intraoperative difficulty, operating time, and postoperative examination abnormalities in subjects undergoing post-traumatic orbital reconstructions. The results showed that medial wall involvement is associated with intraoperative difficulty, and anteriorly positioned fractures are better treated transorbitally.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)