Article
Medicine, General & Internal
Murgova Snezhana, Balchev Georgi
Summary: This study evaluated the changes in RNFL, GCL thickness, and rim and disk areas in myopic eyes before and after OCT examination with refractive correction using contact lenses or glasses. The results showed significant changes in these parameters after correction with glasses or contact lenses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Huiping Yao, Zijian Yang, Yu Cheng, Xi Shen
Summary: This study investigated the changes in macular status and choroidal thickness following phacoemulsification in patients with mild to moderate nonproliferative diabetic retinopathy. The results showed that the increase in SCP-VD, MT, and CT after surgery was significantly greater in diabetic retinopathy patients compared to the control group.
FRONTIERS IN MEDICINE
(2023)
Article
Chemistry, Analytical
Rafael Berenguer-Vidal, Rafael Verdu-Monedero, Juan Morales-Sanchez, Inmaculada Selles-Navarro, Oleksandr Kovalyk, Jose-Luis Sancho-Gomez
Summary: The study aimed to analyze the relevance of asymmetry features between both eyes of the same patient for glaucoma screening using optical coherence tomography. Machine learning models were designed and optimized based on retinal nerve fiber layer asymmetry, providing good classification of patients for the early diagnosis of glaucoma. The models offer a good trade-off in classification of patients and simplicity for glaucoma screening in daily clinical practice.
Article
Health Care Sciences & Services
Sunjin Hwang, Min-Ho Kang, Mincheol Seong, Heeyoon Cho, Yong-Un Shin
Summary: This study compared the OCTA findings between eyes with nearly recovered and partially recovered outer retina after FTMH surgery. It was found that the partially recovered group had a significantly higher choriocapillaris flow-void area at six months postoperatively, while the nearly recovered group showed better choroidal vascular flow. Vision at six months postoperatively correlated with the ratio of the operated eye's choriocapillaris flow-void area to the fellow eye.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Fiorenza Ulgiati, Sophie Lhoir, Irina Balikova, Sylvie Tenoutasse, Emese Boros, Catheline Vilain, Claudine Heinrichs, Cecile Brachet
Summary: This study is the first to document retinal layer thicknesses in patients with Triple A syndrome, finding that nearly all retinal thickness and peripapillary RNFL measurements were significantly lower than the reference range, particularly showing more marked thinning at the temporal part of the optic nerve. OCT, as a non-invasive tool, shows promise in assessing the severity of neurodegeneration in Triple A syndrome patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Kazuyoshi Okawa, Tatsuya Inoue, Ryo Asaoka, Keiko Azuma, Ryo Obata, Rei Arasaki, Shouko Ikeda, Arisa Ito, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
Summary: Cigarette smoking is associated with increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may play an important role in modulating the disease. Age, SE, and past smoking history are key factors influencing SFCT.
Article
Ophthalmology
Jenny L. Hepschke, Elinor Laws, Noor H. Bin Saliman, Stefana Juncu, Ella Courtie, Antonio Belli, Richard J. Blanch
Summary: Traumatic brain injury (TBI) can cause damage and impairment in the visual system, often leading to degeneration of retinal ganglion cells (RGC) without visual symptoms. This study found that macular perfusion remains normal until there is a reduction in GCL thickness, indicating that perfusion changes are secondary to local GCL loss.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Tanja Soehnel, Christof Meigen, Andreas Hiemisch, Siegfried Wahl, Focke Ziemssen, Carolin Truckenbrod, Katharina Huebner, Wieland Kiess
Summary: The purpose of this study was to establish normative data and investigate influencing factors for macular thickness, macular volume, and peripapillary retinal nerve fiber layer (RNFL) thickness in healthy German children and adolescents using Spectralis(R) spectral-domain optical coherence tomography (SD-OCT). The results showed significant correlations between macular thickness and age, axial length, and gender. RNFL thickness was significantly correlated with axial length, birth weight, and a gender-specific effect of body mass index standard deviation score for male participants.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Ophthalmology
Matt Trinh, Natalie Eshow, David Alonso-Caneiro, Michael Kalloniatis, Lisa Nivison-Smith
Summary: This study used high-density optical coherence tomography to compare the retinal topographical differences between intermediate age-related macular degeneration (iAMD) with and without RPD. The results showed that RPD eyes had thinner para-central retina and thicker RPE-BM, suggesting more advanced degeneration. The significance of inner retinal thickening in RPD eyes was unclear.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Magdalena Kal, Mateusz Winiarczyk, Stanislaw Gluszek, Jerzy Mackiewicz
Summary: The study found that the central choroid thickness in patients with lamellar macular holes is significantly thinner than in the control group, and that there is a positive correlation between central choroid thickness and best-corrected visual acuity, but no significant correlation was found with reading vision.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Editorial Material
Ophthalmology
James R. C. Miller, Praveen J. Patel, Daren Hanumunthadu
Summary: Recent advancements in imaging technology have led to increased interest in home monitoring for macular disease. The rise in macular disease prevalence will burden hospital services, making access to clinical care more difficult for patients with age-related macular degeneration and diabetic macular edema. Home monitoring has the potential to improve access to care for low- and moderate-risk patients and detect early signs of disease, but considerations such as technology availability and logistical barriers need to be addressed before large-scale implementation is possible. In addition, access to home monitoring may be more challenging in lower-income communities and countries, requiring appropriate consideration and addressing of health inequality.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Young Ho Kim, Edward Kang, Jaeryung Oh
Summary: This study used en-face optical coherence tomography to investigate the location of pigment epithelial detachment (PED) in relation to various anatomical landmarks in the eye. The results suggest that the development of complicated PED with choroidal neovascularisation (CNV) can be attributed to both choroidal vascular abnormalities and retinal pigment epithelial insufficiency.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Hao Zhou, Jeremy Liu, Rita Laiginhas, Qinqin Zhang, Yuxuan Cheng, Yi Zhang, Yingying Shi, Mengxi Shen, Giovanni Gregori, Philip J. Rosenfeld, Ruikang K. Wang
Summary: An automated algorithm using optical attenuation coefficients (OACs) was developed for visualizing, localizing, and quantifying hyperreflective foci (HRF) associated with macular hyperpigmentation in age-related macular degeneration. The algorithm transformed OCT scans to linear representation and used OACs for contrast. HRF within the retina and along the retinal pigment epithelium (RPE) were differentiated for visualization and localization. The total pigment burden was quantified using an en face sum projection of OACs. The algorithm's measurements were compared with manual segmentations, showing a significant correlation.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Ophthalmology
C. J. Doncel-Fernandez, M. L. Alferez-Asenjo, A. Quereda-Castaneda, G. Castro-Luna
Summary: This study found that patients with pre-surgical macular thickness greater than 260.5 micrometers before uncomplicated cataract surgery are more likely to develop macular intraretinal cysts, without any other significant risk factors.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Computer Science, Information Systems
Odilon L. C. Mendes, Daniel R. Lucena, Abrahao R. Lucena, Tarique S. Cavalcante, Victor Hugo C. De Albuquerque, Meteb Altaf, Mohammad Mehedi Hassan, Auzuir R. Alexandria
Summary: The study aims to develop an algorithm that automatically segments the ILM boundary layer and the area of the MH in OCT images, while also achieving automatic acquisition of MH measurements. Through a set of techniques involving Euclidean Distance, Flood Fill, and Border Following algorithms, the proposed method reached satisfactory results for all applications made. Automatic segmentation of the MH and the extraction of its measures is a significant contribution to aid the medical diagnosis of the macular hole pathology.
Letter
Clinical Neurology
Faheem Arshad, Vikram Singh, Chandrajit Prasad, Ravi Yadav, Suvarna Alladi
ACTA NEUROLOGICA BELGICA
(2023)
Letter
Clinical Neurology
Shreyashi Jha, Dipti Baskar, B. N. Nandeesh, Seena Vengalil, Ravindranadh Chaudhary, Atchayaram Nalini, Ravi Yadav, Dwarkanath Srinivas
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2023)
Review
Clinical Neurology
M. M. Samim, Debjyoti Dhar, Faheem Arshad, D. D. S. Anudeep, Vishal G. Patel, Sriram Ramalakshmi Neeharika, Kamakshi Dhamija, Chowdary Mundlamuri Ravindranath, Ravi Yadav, Pritam Raja, M. Netravathi, Deepak Menon, Vikram V. Holla, Nitish L. Kamble, Pramod K. Pal, Atchayaram Nalini, Seena Vengalil
Summary: This study retrospectively reviewed and reported neurological diseases temporally associated with COVID-19 vaccination, finding that 48 cases had a probable association. Neurological syndromes included CNS demyelination, Guillain-Barre syndrome, stroke, encephalitis, and myositis. Larger sample size and longer follow-up studies are needed to confirm the causality association of these syndromes with COVID-19 vaccination.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Editorial Material
Clinical Neurology
Vikram Holla, Bharat Kumar Surisetti, Shweta Prasad, Koti Neeraja, Nitish Kamble, Babylakshmi Muthusamy, Pramod Kumar Pal, Ravi Yadav
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Dhiraj Srivastava, Ravi P. Yadav, Sneha Singh, Kimberly Boyd, Nikolai O. Artemyev
Summary: PDE6 is important for visual signal transduction and relies on the chaperone complex of HSP90 and AIPL1 for maturation. Disruption of PDE6 maturation leads to severe retina degeneration.
Review
Clinical Neurology
Bharath Kumar Surisetti, Shweta Prasad, Vikram Venkappayya Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal
Summary: Occasionally, movement disorders can occur after interventional procedures, and they can be more disabling than the original disease. Delays in diagnosing and misdiagnoses as functional movement disorders are common due to poor knowledge and awareness. This review discusses the phenomenology, pathophysiology, and potential treatments of movement disorders caused by interventional procedures.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Vikram V. V. Holla, Anush Rangarajan, Gautham Arunachal, Babylakshmi Muthusamy, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal, Manjunath Netravathi
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Sandeep Gurram, Vikram V. V. Holla, Neeharika Sriram, Prashant Phulpagar, Shreyashi Jha, Praveen Sharma, Siddaya Mallithavana, Nitish Kamble, Manjunath Netravathi, Ravi Yadav, Babylakshmi Muthusamy, Pramod Kumar Pal
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Psychiatry
Rahul Patwal, Amal Joseph Jolly, Amit Kumar, Ravi Yadav, Geetha Desai, Harish Thippeswamy
Summary: Patients with functional neurological disorders (FND) present with neurological symptoms without corresponding brain pathology. This study aimed to evaluate the accuracy of clinical signs and electrophysiological investigations in diagnosing FND, as there is currently no gold standard test for FND diagnosis.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Clinical Neurology
Neeharika Sriram, Vikram V. Holla, Riyanka Kumari, Nitish Kamble, Jitender Saini, Rohan Mahale, Manjunath Netravathi, Hansashree Padmanabha, Vykuntaraju K. Gowda, Rajani Battu, Akhilesh Pandey, Ravi Yadav, Babylakshmi Muthusamy, Pramod Kumar Pal
Summary: This study aimed to investigate the clinical, radiological, and genetic features of PKAN. The study found that most patients had symptoms before the age of 10, with difficulty walking and dystonia being the most common symptoms. MRI showed hypo intensity signals in the brain. Genetic testing revealed mutations in the PANK2 gene, with 10 novel variants identified.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Multidisciplinary Sciences
Jeffrey D. Wall, J. Fah Sathirapongsasuti, Ravi Gupta, Asif Rasheed, Radha Venkatesan, Saurabh Belsare, Ramesh Menon, Sameer Phalke, Anuradha Mittal, John Fang, Deepak Tanneeru, Manjari Deshmukh, Akshi Bassi, Jacqueline Robinson, Ruchi Chaudhary, Sakthivel Murugan, Zameer ul-Asar, Imran Saleem, Unzila Ishtiaq, Areej Fatima, Saqib Shafi Sheikh, Shahid Hameed, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Anjum Jalal, Shahid Abbas, Philippe Frossard, Christian Fuchsberger, Lukas Forer, Sebastian Schoenherr, Qixin Bei, Tushar Bhangale, Jennifer Tom, Santosh Gopi Krishna Gadde, B. Priya, Naveen Kumar Naik, Minxian Wang, Pui-Yan Kwok, Amit V. Khera, B. R. Lakshmi, Adam S. Butterworth, Rajiv Chowdhury, John Danesh, Emanuele di Angelantonio, Aliya Naheed, Vinay Goyal, Rukmini M. Kandadai, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp M. Wadia, Ravi Yadav, Soaham Desai, Niraj Kumar, Atanu Biswas, Pramod Kumar Pal, Uday B. Muthane, Shymal K. Das, Vedam L. Ramprasad, Prashanth L. Kukkle, Somasekar Seshagiri, Sekar Kathiresan, Arkasubhra Ghosh, V. Mohan, Danish Saleheen, Eric W. Stawiski, Andrew S. Peterson
Summary: The benefits of large-scale genetic studies for healthcare have been well-documented, but certain populations, such as those from South Asia, have been overlooked. In this study, researchers collected whole genome sequence (WGS) data from individuals in Pakistan, India, Bangladesh, as well as isolated South Asian populations. The study revealed high rates of reproductive isolation, endogamy, and consanguinity in South Asia, leading to a higher prevalence of rare homozygotes compared to outbred populations. Founder effects in South Asia make it an ideal location for population-scale genetic studies.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta
Summary: In this study, we investigated the cell-intrinsic effect of the LRRK2-I1371V mutant variant on astrocyte biology. Our findings reveal that the mutation in the LRRK2-I1371V allele significantly impairs astrocytic function in terms of Nrf2-mediated antioxidant machinery, ATP generation, and glutamate metabolism, despite comparable astrocyte yields.
Article
Neurosciences
Franziska Knolle, Shyam S. Arumugham, Roger A. Barker, Michael W. L. Chee, Azucena Justicia, Nitish Kamble, Jimmy Lee, Siwei Liu, Abhishek Lenka, Simon J. G. Lewis, Graham K. Murray, Pramod Kumar Pal, Jitender Saini, Jennifer Szeto, Ravi Yadav, Juan H. Zhou, Kathrin Koch
Summary: Psychotic symptoms are common in schizophrenia and Parkinson's disease (PD) patients. Altered grey matter structure in various brain areas and networks may contribute to their pathogenesis. This study investigated the similarities in psychotic symptoms between schizophrenia and PD, and found significant grey matter reduction in both PD and early schizophrenia. Classification algorithms based on grey matter values within specific networks showed good accuracy in differentiating early psychosis cases and fair performance in distinguishing PD patients with and without psychotic symptoms. Results suggest some common underlying mechanisms and potential biomarkers for identifying these conditions.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Anikha Bellad, Vikram V. Holla, Riyanka Kumari, Nitish Kamble, Ravi Yadav, Akhilesh Pandey, Pramod Kumar Pal, Babylakshmi Muthusamy
Summary: This study identified novel pathogenic variants in the L2HGDH gene in patients with L2HGA. These findings contribute to the understanding of the genetic basis of L2HGA and highlight the importance of genetic testing for diagnosis and genetic counseling of affected families.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Ragasudha Botta, Keshav J. Kumar, Bindu Kutty, Anita Mahadevan, Pramod Kumar Pal, Ravi Yadav
Summary: This study aimed to validate the NIMHANS Neuropsychological Battery for Elderly (NNB-E) in diagnosing subtle cognitive deficits in Parkinson's Disease (PD) patients and evaluate cognitive impairment compared to healthy controls. The results showed that NNB-E had good internal consistency and construct validity, and it was able to detect mild cognitive impairment in PD patients with high accuracy. The study also revealed that PD patients had poor cognitive performance, particularly in executive and attention domains.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
