Journal
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
Volume 3, Issue 1, Pages 86-99Publisher
WILEY
DOI: 10.1002/wnan.115
Keywords
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Funding
- NIH [R01 HL093038, K08 HL079984, R01EB004472]
- Division Of Materials Research [1056997] Funding Source: National Science Foundation
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K08HL079984, R01HL093038] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB004472] Funding Source: NIH RePORTER
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Apoptosis plays an important role in the loss of cardiomyocytes in both ischemic injury and heart failure. Pioneering work with single photon emission computed tomography imaging of Tc-99-annexin showed that cell death in the heart could be imaged in vivo. Over the last 5 years a significant amount of experience with annexin-labeled magnetic nanoparticles, principally AnxCLIO-Cy5.5, has also been gained. Here, we review the experience with AnxCLIO-Cy5.5 in the heart and compare this experience to that of earlier studies with Tc-99-annexin. The imaging of apoptosis with AnxCLIO-Cy5.5 provides valuable insights not only into molecular imaging in the heart but, more broadly, into the use of nanoparticle technology for molecular imaging in general. (C) 2010 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2011 3 86-99 DOI: 10.1002/wnan.115
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