Review
Chemistry, Medicinal
Stefano Da Pozzo, Pierluigi Iacono, Alessandro Arrigo, Maurizio Battaglia Parodi
Summary: Central serous chorioretinopathy (CSC) is a contentious disease involving various eye structures, with multiple therapeutic options available. Imaging plays a crucial role in evaluating and guiding treatment, while biomarkers serve as diagnostic and prognostic reference points.
Review
Medicine, General & Internal
Sandrine Anne Zweifel, Nastasia Foa, Maximilian Robert Justus Wiest, Adriano Carnevali, Katarzyna Zaluska-Ogryzek, Robert Rejdak, Mario Damiano Toro
Summary: Differential diagnosis between ocular infections caused by Mycobacterium chimaera and tuberculosis can be challenging, but multimodal imaging techniques are crucial for early diagnosis, monitoring treatment response, and guiding clinical decisions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Rait Parmann, Stephen H. Tsang, Janet R. Sparrow
Summary: The quantitative fundus autofluorescence method can assess the levels of bisretinoids in retinal pigment epithelium cells, aiding in the interpretation and management of retinal conditions. Some retinal diseases have known mechanisms for increased fundus autofluorescence, while others do not. Impairment and degeneration of photoreceptor cells may contribute to secondary autofluorescence elevation in these cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Sibel Demirel, Nilufer Yalcindag, Ozge Yanik, Figen Batioglu, Emin Ozmert
Summary: A female patient with CNV was not obvious in fluorescein angiography but was detected with OCTA. After systemic therapy, OCTA scans revealed Type 1 CNV in the peripapillary area.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Review
Ophthalmology
Akshay S. Thomas, Phoebe Lin
Summary: Multimodal ocular imaging plays a critical role in the diagnosis and assessment of treatment response in uveitis, providing insights into disease pathogenesis and monitoring not previously appreciated.
CURRENT OPINION IN OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Gagan Kalra, Aniruddha Agarwal, Alessandro Marchese, Rupesh Agrawal, Reema Bansal, Vishali Gupta
Summary: A fully automated pipeline was developed and evaluated for analyzing color fundus images in patients with tubercular serpiginous-like choroiditis (TB SLC) to predict paradoxical worsening (PW). The pipeline showed good repeatability in predicting PW by calculating lesion metrics such as mean pixel intensity and segmented area. It could potentially serve as a useful tool in the follow-up of TB SLC patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Digdem Tetik, Ahmet Kaan Gunduz
Summary: We report a case of idiopathic sclerochoroidal calcification evaluated with multimodal imaging, including FAF, USG, OCT, OCTA, and FA, to help identify distinguishing features of the tumor and differentiate it from other entities.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Ophthalmology
Alessandro Arrigo, Emanuela Aragona, Alessandro Bordato, Alessandro Calamuneri, Alessio Grazioli Moretti, Stefano Mercuri, Francesco Bandello, Maurizio Battaglia Parodi
Summary: The study aimed to differentiate acute central serous chorioretinopathy (CSC) subtypes by using multimodal imaging. Two main subtypes, retinal pigment epithelium-related CSC (RPE-CSC) and choroidal-related CSC (choroidal-CSC), were identified based on quantitative pachychoroid cutoff values, showing differing responses to treatment and development of macular neovascularization (MNV).
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Rait Parmann, Vivienne C. Greenstein, Stephen H. Tsang, Janet R. Sparrow
Summary: This study evaluated scotopic sensitivity and outer retinal structure in choroideremia carriers using dark adapted chromatic perimetry and multi-modal imaging. The results showed comparable scotopic sensitivity in carriers' macular and peripheral areas compared to control group, but significantly decreased sensitivity in the peripapillary area where retinal structure changes were most severe.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Oncology
Yongyue Su, Xiongze Zhang, Yuhong Gan, Yunkao Zeng, Feng Wen
Summary: This study found that OCTA has a superior detection rate and accuracy for identifying PNV compared to dye angiography. Patients with PNV eyes differed significantly from those without PNV eyes in terms of age, history of the disease, and visual acuity.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Ophthalmology
Anthony C. Oganov, Ian Seddon, Sayena Jabbehdari, Ogul E. Liner, Hossein Fonoudi, Ghasem Yazdanpanah, Oumaima Outani, J. Fernando Arevalo
Summary: Modern advances in diagnostic technologies have revolutionized the understanding of ophthalmic conditions related to the retina. This review explores the current use of artificial intelligence in screening, diagnosing, and monitoring retinal pathologies, such as diabetic retinopathy, macular edema, chorioretinopathy, and macular degeneration. The paper discusses the methods used in these models, evaluates their performance in both research and clinical settings, and highlights future directions and challenges in applying artificial intelligence in retinal pathologies.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Ari Shinojima, Yoko Ozawa, Atsuro Uchida, Norihiro Nagai, Hajime Shinoda, Toshihide Kurihara, Misa Suzuki, Sakiko Minami, Kazuno Negishi, Kazuo Tsubota
Summary: This study assessed the HFF in CSC using different imaging techniques and found that NIR-AF was the easiest method to detect HFF on late-phase ICGA, which may indicate melanin abnormalities in the retinal pigment epithelium.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jie Li, Dingyang Wei, Mingzhu Mao, Mengyu Li, Sanmei Liu, Fang Li, Li Chen, Miao Liu, Hongmei Leng, Yiya Wang, Xinru Ning, Yi Liu, Wentao Dong, Jie Zhong
Summary: This study aimed to compare the detection rate of DR lesions and the agreement of DR severity grading using UWF CFP combined with UWF SS-OCTA or FFA. The results showed good agreement between the two combination methods in detecting DR lesions and determining the severity of DR.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Ophthalmology
Marco Pellegrini, Giovanni Staurenghi, Manuela Mambretti, Chiara Preziosa
Summary: Double-fluence photodynamic therapy has been shown to be effective and safe for the treatment of circumscribed choroidal hemangioma and should be considered as the first line of treatment for these lesions.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Kimberly Spooner, Long Phan, Mariano Cozzi, Thomas Hong, Giovanni Staurenghi, Eugenia Chu, Andrew A. Chang
Summary: The study found that there were no significant differences in retinal measurements between the two OCT devices, and common ultrastructural biomarkers of multiple macular pathologies demonstrated high sensitivity and specificity, indicating comparable confidence in retinal imaging between the two devices.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Carsten H. Meyer, Miriam Adamcova, Eduardo B. Rodrigues, Boris Stanzel, Michael Janusz Koss
Summary: Firm adhesions between the retina and adjacent retinal pigment epithelium may prevent the closure of macular holes after chromovitrectomy. Controlled application of subretinal fluid can release these adhesions and lead to closure of the retracted retina in large or refractory macular holes. With a standardized procedure, the operation can be carried out safely and with minimal material effort, resulting in a high secondary closure rate.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2021)
Review
Ophthalmology
Gustavo Barreto Melo, Natasha Ferreira Santos da Cruz, Geoffrey Guy Emerson, Flavio Atanazio Rezende, Carsten H. Meyer, Susumu Uchiyama, John Carpenter, Helio Francisco Shiroma, Michel Eid Farah, Maurcio Maia, Eduardo Buchele Rodrigues
Summary: Intravitreal injections are commonly performed for eye treatments, but may cause severe complications. Therefore, physicians must be cautious in selecting materials and techniques to prevent adverse events.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Editorial Material
Ophthalmology
Sandeep Saxena, Carsten H. Meyer, Levent Akduman
Summary: The use of SD-OCT allows for the detailed observation of ELM and EZ, and in DME, the correlation between increased VEGF levels and disease severity, retinal thickness, and disruption of ELM and EZ has been established. Following anti-VEGF therapy, the restoration of ELM precedes that of EZ, highlighting ELM as a novel retinal structural barrier.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Dana Zvi, Dinah Zur, Shula Schwartz, Shai Cohen, Avi Saranga, Anat Loewenstein, Michaella Goldstein
Summary: This study evaluates the difference in treatment decisions between face-to-face clinical examination and virtual evaluation using visual acuity and OCT scans in nvAMD patients. The results show that the virtual evaluation method produces similar treatment decisions compared to the standard face-to-face examination.
Article
Ophthalmology
Gilad Rabina, Assaf Hilely, Dana Barequet, Shai Cohen, Naama Lipin, Michael Mimouni, Adina Glick, Adiel Barak, Anat Loewenstein, Shulamit Schwartz
Summary: This study compared the outcomes of pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peeling in diabetic retinopathy patients with and without diabetic macular edema (DME). The results showed that DME patients experienced significant improvement in visual acuity, macular thickness, and the need for intravitreal injections after surgery. DME patients were younger, had longer duration of diabetes, and higher HbA1C levels compared to diabetic ERM patients without DME.
Editorial Material
Ophthalmology
Anat Loewenstein, Dara Conlon
Article
Ophthalmology
Reut Shor, Adiel Barak, Anat Loewenstein, Marganit Shahar-Gonen, Michaella Goldstein, Ronni Gamzu, Dinah Zur
Summary: This study aimed to explore the dose-response relationship of anti-VEGF agents in the treatment of neovascular AMD patients. The results showed that only patients with low baseline VA had a dose-response relationship. Individual patient characteristics should be taken into account to improve visual outcome.
Article
Ophthalmology
Daniel M. Handzel, Carsten H. Meyer, Alfred Wegener
Summary: This study explored the possibility of using three contactless devices to measure CCT in cataract patients pre- and post-operatively. The results showed a significant increase and subsequent decrease in CCT with all three devices at all postoperative time points, except for the rotating Scheimpflug camera.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sandeep Saxena, Malvika Singh, Anupriya Chaubey, Akshay Mohan, Somnath De, Apjit Kaur, Jagjit S. Gilhotra, Carsten H. Meyer, Levent Akduman
Summary: This study evaluated the improvement in grades of topographic retinal pigment epithelium alterations (RPE-A) using spectral domain optical coherence tomography (SD-OCT) after intravitreal anti-VEGF therapy in patients with diabetic macular edema (DME). The results showed a significant improvement in RPE-A grades and reduction in central subfield thickness (CST) and cube average thickness (CAT) in the macular area post-intervention.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Editorial Material
Ophthalmology
Carsten H. H. Meyer, Sandeep Saxena
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Nir Gomel, Reut Shor, Naama Lippin, Ori Segal, Eran Greenbaum, Shulamit Schwartz, Omer Trivizki, Anat Loewenstein, Gilad Rabina
Summary: This study evaluated the impact of unplanned treatment gap during the COVID-19 pandemic lockdown on visual acuity in previously treated DME patients. The results showed that the lockdown led to a decrease in the number of anti-VEGF injections, but for most patients, returning to routine treatment was sufficient to maintain visual acuity, with no significant impact.
Article
Ophthalmology
Flavio A. Rezende, Bruna G. Ferreira, Emmanouil Rampakakis, David H. Steel, Michael J. Koss, Zofia A. Nawrocka, Daniela Bacherini, Eduardo B. Rodrigues, Carsten H. Meyer, Tomaso Caporossi, Tamer H. Mahmoud, Stanislao Rizzo, Mark W. Johnson, Jay S. Duker
Summary: The CLOSE study group proposes an updated surgical classification for large macular holes based on a systematic review of new treatments. The need for an updated surgical classification arises from the introduction of many new techniques to treat large macular holes, but the indications are unclear.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Editorial Material
Respiratory System
Carmen Pizarro, Carsten Meyer, Joachim Schmidt, Dirk Skowasch
Summary: Haemoptysis is the expectoration of blood from the tracheobronchial tree and lung. Severe cases can lead to asphyxia, requiring immediate intervention.
Article
Ophthalmology
Gustavo Barreto Melo, Lucas Andrade Santos, Lydianne Lumack do Monte Agra, Carsten Meyer, Morten Carstens Moe, Oystein Kalsnes Jorstad
Meeting Abstract
Ophthalmology
Scott Sonne, Yigit C. Akduman, Carsten Meyer, Sandeep Saxena
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
