Prediction of arrhythmia susceptibility through mathematical modeling and machine learning

Classifying Drugs by their Arrhythmogenic Risk Using Machine Learning

(2020) Francisco Sahli-Costabal et al.   BIOPHYSICAL JOURNAL

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

(2020) Najim Lahrouchi et al.   CIRCULATION

A Computational Pipeline to Predict Cardiotoxicity

(2020) Pei-Chi Yang et al.   CIRCULATION RESEARCH

Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia

(2020) Namit Gaur et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Artificial intelligence–enabled rapid diagnosis of patients with COVID-19

(2020) Xueyan Mei et al.   NATURE MEDICINE

Artificial Intelligence and Machine Learning in Arrhythmias and Cardiac Electrophysiology

(2020) Albert K. Feeny et al.   Circulation-Arrhythmia and Electrophysiology

Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19)

(2020) John R. Giudicessi et al.   MAYO CLINIC PROCEEDINGS

Opening the Black Box: Interpretable Machine Learning for Geneticists

(2020) Christina B. Azodi et al.   TRENDS IN GENETICS

QT Assessment in Early Drug Development: The Long and the Short of It

(2019) Robert M. Lester et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Applications of machine learning in drug discovery and development

(2019) Jessica Vamathevan et al.   NATURE REVIEWS DRUG DISCOVERY

Development and Validation of a Deep-Learning Model to Screen for Hyperkalemia From the Electrocardiogram

(2019) Conner D. Galloway et al.   JAMA Cardiology

Drug‐induced Shortening of the Electromechanical Window is an Effective Biomarker for in Silico Prediction of Clinical Risk of Arrhythmias

(2019) Elisa Passini et al.   BRITISH JOURNAL OF PHARMACOLOGY

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

(2019) Zhihua Li et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II

(2019) Keiji Ogura et al.   Scientific Reports

A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research

(2018) Haibo Ni et al.   Frontiers in Physiology

Slow Delayed Rectifier Current Protects Ventricular Myocytes From Arrhythmic Dynamics Across Multiple Species

(2018) Meera Varshneya et al.   Circulation-Arrhythmia and Electrophysiology

Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network

(2018) Awni Y. Hannun et al.   NATURE MEDICINE

Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy

(2018) Jonas Skogestad et al.   Frontiers in Physiology

Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium

(2018) Daniel M. Johnson et al.   Frontiers in Physiology

Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features

(2017) Jaimit Parikh et al.   Frontiers in Pharmacology

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

(2017) Kelly C. Chang et al.   Frontiers in Physiology

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

(2017) Oliver J. Britton et al.   Frontiers in Physiology

Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms

(2016) M Cummins Lancaster et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

(2016) Elisa Passini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Predicting drug-induced QT prolongation and torsades de pointes

(2016) Dan M. Roden   JOURNAL OF PHYSIOLOGY-LONDON

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility

(2016) Ryan A. Devenyi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition

(2016) E. Pueyo et al.   PLoS One

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

(2016) Anna Muszkiewicz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Targeting the late component of the cardiac L-type Ca2+current to suppress early afterdepolarizations

(2015) Roshni V. Madhvani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Perspective: A dynamics-based classification of ventricular arrhythmias

(2015) James N. Weiss et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regularization Paths for Generalized Linear Models via Coordinate Descent

(2015) Jerome Friedman et al.   Journal of Statistical Software

Tuning hERG Out: Antitarget QSAR Models for Drug Development

(2014) Rodolpho Braga et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Comprehensive Analyses of Ventricular Myocyte Models Identify Targets Exhibiting Favorable Rate Dependence

(2014) Megan A. Cummins et al.   PLoS Computational Biology

Arrhythmias in Structural Heart Disease

(2014) H. Sawyer Gillespie et al.   Current Cardiology Reports

Replacing the thorough QT study: reflections of a baby in the bath water

(2013) Robert B. Kleiman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets

(2013) Yuanfang Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers

(2011) Prince J. Kannankeril et al.   HEART RHYTHM

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Shaping a new Ca2+conductance to suppress early afterdepolarizations in cardiac myocytes

(2011) Roshni V. Madhvani et al.   JOURNAL OF PHYSIOLOGY-LONDON

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

NWChem: A comprehensive and scalable open-source solution for large scale molecular simulations

(2010) M. Valiev et al.   COMPUTER PHYSICS COMMUNICATIONS

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL