Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility

There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes

(2016) Ryan A. Devenyi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

(2016) Trine Krogh-Madsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve

(2016) Sara Dutta et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

(2016) Anna Muszkiewicz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular CardiomyocytesNovelty and Significance

(2015) Xin Zhou et al.   CIRCULATION RESEARCH

Repolarization Reserve Evolves Dynamically During the Cardiac Action Potential

(2015) Thao P. Nguyen et al.   Circulation-Arrhythmia and Electrophysiology

Targeting the late component of the cardiac L-type Ca2+current to suppress early afterdepolarizations

(2015) Roshni V. Madhvani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Perspective: A dynamics-based classification of ventricular arrhythmias

(2015) James N. Weiss et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cell-Specific Cardiac Electrophysiology Models

(2015) Willemijn Groenendaal et al.   PLoS Computational Biology

Beta-adrenergic stimulation reverses the I Kr–I Ks dominant pattern during cardiac action potential

(2014) Tamas Banyasz et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Fitting Membrane Resistance along with Action Potential Shape in Cardiac Myocytes Improves Convergence: Application of a Multi-Objective Parallel Genetic Algorithm

(2014) Jaspreet Kaur et al.   PLoS One

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

(2014) Arash Sadrieh et al.   Nature Communications

Disrupted Calcium Release as a Mechanism for Atrial Alternans Associated with Human Atrial Fibrillation

(2014) Kelly C. Chang et al.   PLoS Computational Biology

Comprehensive Analyses of Ventricular Myocyte Models Identify Targets Exhibiting Favorable Rate Dependence

(2014) Megan A. Cummins et al.   PLoS Computational Biology

Parameter Sensitivity Analysis of Stochastic Models Provides Insights into Cardiac Calcium Sparks

(2013) Young-Seon Lee et al.   BIOPHYSICAL JOURNAL

Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve

(2013) Zhilin Qu et al.   CARDIOVASCULAR RESEARCH

Electronic “expression” of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells

(2013) Glenna C.L. Bett et al.   HEART RHYTHM

Yoga for the sinoatrial node: Sarcoplasmic reticulum calcium release confers flexibility

(2013) Megan A. Cummins et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca2+ clock generate robust, flexible, and energy-efficient cardiac pacemaking

(2013) Victor A. Maltsev et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram

(2013) Arash Sadrieh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis

(2013) Jordi Heijman et al.   PLoS Computational Biology

“Good Enough Solutions” and the Genetics of Complex Diseases

(2012) James N. Weiss et al.   CIRCULATION RESEARCH

Epistatic Effects of Potassium Channel Variation on Cardiac Repolarization and Atrial Fibrillation Risk

(2012) Stefan A. Mann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hierarchical Cluster-based Partial Least Squares Regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models

(2011) Kristin Tøndel et al.   BMC Systems Biology

Arrhythmogenic consequences of myofibroblast–myocyte coupling

(2011) Thao P. Nguyen et al.   CARDIOVASCULAR RESEARCH

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp

(2011) Tamas Banyasz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Shaping a new Ca2+conductance to suppress early afterdepolarizations in cardiac myocytes

(2011) Roshni V. Madhvani et al.   JOURNAL OF PHYSIOLOGY-LONDON

Variability, compensation, and modulation in neurons and circuits

(2011) E. Marder   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early afterdepolarizations and cardiac arrhythmias

(2010) James N. Weiss et al.   HEART RHYTHM

How different two almost identical action potentials can be: A model study on cardiac repolarization

(2010) Massimiliano Zaniboni et al.   MATHEMATICAL BIOSCIENCES

Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells

(2010) Amrita X. Sarkar et al.   PLoS Computational Biology

Anthropomorphizing the Mouse Cardiac Action Potential via a Novel Dynamic Clamp Method

(2009) Rebecca C. Ahrens-Nicklas et al.   BIOPHYSICAL JOURNAL

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

Uniqueness and Stability of Action Potential Models during Rest, Pacing, and Conduction Using Problem-Solving Environment

(2009) Leonid Livshitz et al.   BIOPHYSICAL JOURNAL

Reverse rate dependency is an intrinsic property of canine cardiac preparations

(2009) Tamás Bányász et al.   CARDIOVASCULAR RESEARCH

Control of the cardiac action potential: The role of repolarization dynamics

(2009) Antonio Zaza   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A novel computational model of the human ventricular action potential and Ca transient

(2009) Eleonora Grandi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias

(2009) D. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using Complicated, Wide Dynamic Range Driving to Develop Models of Single Neurons in Single Recording Sessions

(2008) Kevin H. Hobbs et al.   JOURNAL OF NEUROPHYSIOLOGY