Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium

P519Regional heterogeneity of hyperactive non-coupled ryanodine receptors makes the peri-infarct region more prone to triggered activities after myocardial infarction

(2018) E Dries et al.   CARDIOVASCULAR RESEARCH

Hyperactive ryanodine receptors in human heart failure and ischaemic cardiomyopathy reside outside of couplons

(2018) Eef Dries et al.   CARDIOVASCULAR RESEARCH

Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart FailureNovelty and Significance

(2018) Swati Dey et al.   CIRCULATION RESEARCH

Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes

(2018) Bence Hegyi et al.   Circulation-Arrhythmia and Electrophysiology

EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2

(2018) Robert C. Klipp et al.   HEART RHYTHM

Calcium/calmodulin-dependent protein kinase II regulation of I Ks during sustained β-adrenergic receptor stimulation

(2018) Tyler Shugg et al.   HEART RHYTHM

Paradoxical Effects of Sodium-Calcium Exchanger Inhibition on Torsade de Pointes and Early Afterdepolarization in a Heart Failure Rabbit Model

(2018) Po-Cheng Chang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity

(2018) S. Lebek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nitric oxide signalling in cardiovascular health and disease

(2018) Charlotte Farah et al.   Nature Reviews Cardiology

Complex electrophysiological remodeling in postinfarction ischemic heart failure

(2018) Bence Hegyi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial

(2017) Jean-Sébastien Hulot et al.   EUROPEAN JOURNAL OF HEART FAILURE

Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes

(2017) Nico Hartmann et al.   HEART RHYTHM

β-Adrenergic induced SR Ca 2+ leak is mediated by an Epac-NOS pathway

(2017) Laëtitia Pereira et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechano-chemo-transduction in cardiac myocytes

(2017) Ye Chen-Izu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Management of Ventricular Arrhythmias in Patients With Advanced Heart Failure

(2017) Pasquale Santangeli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology

(2017) Yohei Yamaguchi et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Mechano-electrical feedback in the clinical setting: Current perspectives

(2017) M. Orini et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Mechanosensitivity of microdomain calcium signalling in the heart

(2017) Patrick Schönleitner et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions

(2017) Xiao-Hong Wei et al.   Scientific Reports

Contribution of Autonomic Reflexes to the Hyperadrenergic State in Heart Failure

(2017) Edgar Toschi-Dias et al.   Frontiers in Neuroscience

Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration

(2017) Bradley Porter et al.   Frontiers in Physiology

Late Ca 2+ Sparks and Ripples During the Systolic Ca 2+ Transient in Heart Muscle Cells

(2017) Ewan D. Fowler et al.   CIRCULATION RESEARCH

Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+waves induced by cAMP-phosphodiesterase inhibitors

(2016) Pierre Bobin et al.   CARDIOVASCULAR RESEARCH

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

(2016) Michael Frisk et al.   CARDIOVASCULAR RESEARCH

The role of Epac in the heart

(2016) Takayuki Fujita et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)–Organized DyadsCLINICAL PERSPECTIVE

(2016) Ying Fu et al.   CIRCULATION

Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart FailureNovelty and Significance

(2016) Federica Barbagallo et al.   CIRCULATION RESEARCH

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart FailureNovelty and Significance

(2016) Jose L. Sanchez-Alonso et al.   CIRCULATION RESEARCH

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion

(2016) Jinli Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcium/calmodulin-dependent kinase II and nitric oxide synthase 1-dependent modulation of ryanodine receptors during β-adrenergic stimulation is restricted to the dyadic cleft

(2016) Eef Dries et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial

(2016) Barry Greenberg et al.   LANCET

New medications for heart failure

(2016) Jonathan S. Gordin et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Evidence for redox sensing by a human cardiac calcium channel

(2016) Padmapriya Muralidharan et al.   Scientific Reports

Acute Myocardial Response to Stretch: What We (don't) Know

(2016) João S. Neves et al.   Frontiers in Physiology

Nitric Oxide Synthase 1 Modulates Basal and β-Adrenergic-Stimulated Contractility by Rapid and Reversible Redox-Dependent S-Nitrosylation of the Heart

(2016) Alejandra Z. Vielma et al.   PLoS One

Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertension

(2015) W.-W. Chen et al.   Acta Physiologica

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1

(2015) B. Doleschal et al.   CARDIOVASCULAR RESEARCH

Arrhythmogenic Remodeling of  2 Versus  1 Adrenergic Signaling in the Human Failing Heart

(2015) D. Lang et al.   Circulation-Arrhythmia and Electrophysiology

Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules and Ca2+Sparks Produced by Dyssynchronous Heart Failure

(2015) Hui Li et al.   Circulation-Heart Failure

Calcium release near l-type calcium channels promotes beat-to-beat variability in ventricular myocytes from the chronic AV block dog

(2015) Gudrun Antoons et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effect of myofilament Ca2+ sensitivity on Ca2+ wave propagation in rat ventricular muscle

(2015) Masahito Miura et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

(2015) Simon M. Bryant et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of the Selective Stretch-Activated Channel Blocker GsMtx4 on Stretch-Induced Changes in Refractoriness in Isolated Rat Hearts and on Ventricular Premature Beats and Arrhythmias after Coronary Occlusion in Swine

(2015) José A. Barrabés et al.   PLoS One

Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response

(2015) William Catterall   Current Molecular Pharmacology

Selective Na+/Ca2+exchanger inhibition prevents Ca2+overload-induced triggered arrhythmias

(2014) Norbert Nagy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa

(2014) Nataliya Dybkova et al.   CARDIOVASCULAR RESEARCH

Hyperactive Adverse Mechanical Stress Responses in Dystrophic Heart Are Coupled to Transient Receptor Potential Canonical 6 and Blocked by cGMP–Protein Kinase G Modulation

(2014) Kinya Seo et al.   CIRCULATION RESEARCH

Transient Receptor Potential Channels Contribute to Pathological Structural and Functional Remodeling After Myocardial Infarction

(2014) Catherine A. Makarewich et al.   CIRCULATION RESEARCH

Dependence of Cardiac Transverse Tubules on the BAR Domain Protein Amphiphysin II (BIN-1)

(2014) Jessica L. Caldwell et al.   CIRCULATION RESEARCH

Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias

(2014) Dobromir Dobrev et al.   CIRCULATION RESEARCH

Nitric oxide synthase regulation of cardiac excitation–contraction coupling in health and disease

(2014) Jillian N. Simon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes

(2014) Serge Viatchenko-Karpinski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Redox regulation of cardiac hypertrophy

(2014) Can M. Sag et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Decreased inward rectifying K+current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart

(2014) Rachel C. Myles et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cyclic AMP synthesis and hydrolysis in the normal and failing heart

(2014) Aziz Guellich et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Nitric Oxide-Dependent Activation of CaMKII Increases Diastolic Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes in Response to Adrenergic Stimulation

(2014) Jerry Curran et al.   PLoS One

Mechanochemotransduction During Cardiomyocyte Contraction Is Mediated by Localized Nitric Oxide Signaling

(2014) Z. Jian et al.   Science Signaling

Ca2+ current facilitation is CaMKII-dependent and has arrhythmogenic consequences

(2014) Donald M. Bers et al.   Frontiers in Pharmacology

Tetrahydrobiopterin in Cardiovascular Health and Disease

(2013) Jennifer K. Bendall et al.   ANTIOXIDANTS & REDOX SIGNALING

Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition

(2013) Mara Ferrandi et al.   BRITISH JOURNAL OF PHARMACOLOGY

ROS regulation of microdomain Ca2+ signalling at the dyads

(2013) Huiliang Zhang et al.   CARDIOVASCULAR RESEARCH

Emerging mechanisms of T-tubule remodelling in heart failure

(2013) Ang Guo et al.   CARDIOVASCULAR RESEARCH

NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle

(2013) Daniel A. Gutierrez et al.   CARDIOVASCULAR RESEARCH

Oxidized Ca 2+ /Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation

(2013) Anil Purohit et al.   CIRCULATION

Accelerated Sinus Rhythm Prevents Catecholaminergic Polymorphic Ventricular Tachycardia in Mice and in Patients

(2013) Michela Faggioni et al.   CIRCULATION RESEARCH

Mechanisms of Altered Ca 2+ Handling in Heart Failure

(2013) Min Luo et al.   CIRCULATION RESEARCH

Selective Modulation of Coupled Ryanodine Receptors During Microdomain Activation of Calcium/Calmodulin-Dependent Kinase II in the Dyadic Cleft

(2013) Eef Dries et al.   CIRCULATION RESEARCH

Ca2+ Fluxes Involvement in Gene Expression During Cardiac Hypertrophy

(2013) Ana Gomez et al.   Current Vascular Pharmacology

The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias

(2013) B Daan Westenbrink et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes

(2013) Can M. Sag et al.   FREE RADICAL BIOLOGY AND MEDICINE

To the Editor— Propranolol, a β-adrenoreceptor blocker, prevents arrhythmias also by its sodium channel blocking effect

(2013) Larissa Fabritz et al.   HEART RHYTHM

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling

(2013) Peter T. Wright et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ventricular Arrhythmias and Implantable Cardioverter-Defibrillator Therapy in Patients With Continuous-Flow Left Ventricular Assist Devices

(2013) Arthur R. Garan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Anrep effect: 100 years later

(2012) Horacio E. Cingolani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox Regulation of Sodium and Calcium Handling

(2012) Stefan Wagner et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases in Heart Failure: Poachers or Gamekeepers?

(2012) Min Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric Oxide Synthases in Heart Failure

(2012) Ricardo Carnicer et al.   ANTIOXIDANTS & REDOX SIGNALING

CaMKIIδC Slows [Ca]i Decline in Cardiac Myocytes by Promoting Ca Sparks

(2012) Tao Guo et al.   BIOPHYSICAL JOURNAL

Redox Signaling in Cardiac Physiology and Pathology

(2012) Joseph R. Burgoyne et al.   CIRCULATION RESEARCH

Calmodulin-Dependent Protein Kinase II: Linking Heart Failure and Arrhythmias

(2012) Paari Dominic Swaminathan et al.   CIRCULATION RESEARCH

Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After β-Adrenergic Stimulation

(2012) Daniel M. Johnson et al.   CIRCULATION RESEARCH

Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca2+-induced Ca2+release in a rodent model of heart failure

(2012) Michael Ibrahim et al.   EUROPEAN JOURNAL OF HEART FAILURE

Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy

(2012) Ting-Ting Hong et al.   HEART RHYTHM

New Insights into the Beneficial Electrophysiologic Profile of Ranolazine in Heart Failure: Prevention of Ventricular Fibrillation With Increased Postrepolarization Refractoriness and Without Drug-Induced Proarrhythmia

(2012) Gerrit Frommeyer et al.   JOURNAL OF CARDIAC FAILURE

The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?

(2012) Thomas H. Fischer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ca2+ channel and Na+/Ca2+ exchange localization in cardiac myocytes

(2012) David R.L. Scriven et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Not All Beta-Blockers Are Equal in the Management of Long QT Syndrome Types 1 and 2

(2012) Priya Chockalingam et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Altered sarcoplasmic reticulum calcium cycling—targets for heart failure therapy

(2012) Changwon Kho et al.   Nature Reviews Cardiology

Microtubules Underlie Dysfunction in Duchenne Muscular Dystrophy

(2012) R. J. Khairallah et al.   Science Signaling

Ca2+-induced delayed afterdepolarizations are triggered by dyadic subspace Ca2+ affirming that increasing SERCA reduces aftercontractions

(2011) Martin Fink et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

TRPC Channels As Effectors of Cardiac Hypertrophy

(2011) Petra Eder et al.   CIRCULATION RESEARCH

Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late I Na Augmentation Leading to Cellular Na and Ca Overload

(2011) Stefan Wagner et al.   CIRCULATION RESEARCH

SERCA2a Gene Transfer Decreases Sarcoplasmic Reticulum Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure

(2011) Alexander R. Lyon et al.   Circulation-Arrhythmia and Electrophysiology

Local control in cardiac E–C coupling

(2011) M.B. Cannell et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Microdomain [Ca2+] near ryanodine receptors as reported by L-type Ca2+and Na+/Ca2+exchange currents

(2011) Karoly Acsai et al.   JOURNAL OF PHYSIOLOGY-LONDON

Alternative strategies in arrhythmia therapy: Evaluation of Na/Ca exchange as an anti-arrhythmic target

(2011) Gudrun Antoons et al.   PHARMACOLOGY & THERAPEUTICS

Subcellular Heterogeneity of Ryanodine Receptor Properties in Ventricular Myocytes with Low T-Tubule Density

(2011) Liesbeth Biesmans et al.   PLoS One

X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart

(2011) B. L. Prosser et al.   SCIENCE

So Little Source, So Much Sink: Requirements for Afterdepolarizations to Propagate in Tissue

(2010) Yuanfang Xie et al.   BIOPHYSICAL JOURNAL

Sodium-Calcium Exchange Is Essential for Effective Triggering of Calcium Release in Mouse Heart

(2010) Patricia Neco et al.   BIOPHYSICAL JOURNAL

Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure

(2010) Ralph J. van Oort et al.   CIRCULATION

Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation

(2010) Izhak Kehat et al.   CIRCULATION

Elevated Cytosolic Na + Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes

(2010) Michael Kohlhaas et al.   CIRCULATION

In the RyR2 R4496C Mouse Model of CPVT, β-Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves

(2010) Takeshi Kashimura et al.   CIRCULATION RESEARCH

Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel

(2010) Man Liu et al.   CIRCULATION RESEARCH

Inhibition of Elevated Ca 2+ /Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium

(2010) Samuel Sossalla et al.   CIRCULATION RESEARCH

Dyssynchrony of Ca2+ release from the sarcoplasmic reticulum as subcellular mechanism of cardiac contractile dysfunction

(2010) Frank R. Heinzel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptorS-nitrosylation

(2010) Honglan Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules

(2010) Ting-Ting Hong et al.   PLOS BIOLOGY

Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress

(2009) Norishige Morita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neuronal Nitric Oxide Synthase Protects Against Myocardial Infarction-Induced Ventricular Arrhythmia and Mortality in Mice

(2009) Dylan E. Burger et al.   CIRCULATION

Axial Stretch of Rat Single Ventricular Cardiomyocytes Causes an Acute and Transient Increase in Ca 2+ Spark Rate

(2009) Gentaro Iribe et al.   CIRCULATION RESEARCH

Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure

(2009) Can M. Sag et al.   Circulation-Heart Failure

Catecholaminergic polymorphic ventricular tachycardia: A paradigm to understand mechanisms of arrhythmias associated to impaired Ca2+ regulation

(2009) Marina Cerrone et al.   HEART RHYTHM

IKs restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation

(2009) Daniel M. Johnson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

L-type Ca2+ channel facilitation mediated by H2O2-induced activation of CaMKII in rat ventricular myocytes

(2009) Young-Hwan Song et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanosensitive TRP channels in cardiovascular pathophysiology

(2009) Ryuji Inoue et al.   PHARMACOLOGY & THERAPEUTICS

Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart

(2009) A. R. Lyon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias

(2009) D. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial nitric oxide synthase decreases β-adrenergic responsiveness via inhibition of the L-type Ca2+ current

(2008) Honglan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Spatial non-uniformity of excitation-contraction coupling can enhance arrhythmogenic-delayed afterdepolarizations in rat cardiac muscle

(2008) M. Miura et al.   CARDIOVASCULAR RESEARCH

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin

(2008) An L. Moens et al.   CIRCULATION

Arrhythmogenic Effects of β 2 -Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load

(2008) Jaime DeSantiago et al.   CIRCULATION RESEARCH

Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling

(2008) Lai-Hua Xie et al.   CIRCULATION RESEARCH

Increased Ca 2+ Sensitivity of the Ryanodine Receptor Mutant RyR2 R4496C Underlies Catecholaminergic Polymorphic Ventricular Tachycardia

(2008) María Fernández-Velasco et al.   CIRCULATION RESEARCH

Epac and Phospholipase Cϵ Regulate Ca2+Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

(2008) Emily A. Oestreich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal of Cardiac Dysfunction After Long-Term Expression of SERCA2a by Gene Transfer in a Pre-Clinical Model of Heart Failure

(2008) Yoshiaki Kawase et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Oxidation of multiple methionine residues impairs rapid sodium channel inactivation

(2008) Mario Kassmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium Sparks

(2008) Heping Cheng et al.   PHYSIOLOGICAL REVIEWS

Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?

(2008) S. R. Houser et al.   Science Signaling

Differential role of S-nitrosylation and the NO–cGMP–PKG pathway in cardiac contractility

(2007) Daniel R. González et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY