Predicting drug-induced QT prolongation and torsades de pointes

Molecular Basis of Hypokalemia-Induced Ventricular FibrillationCLINICAL PERSPECTIVE

(2015) Arash Pezhouman et al.   CIRCULATION

Safety of Oral Dofetilide for Rhythm Control of Atrial Fibrillation and Atrial Flutter

(2015) JoEllyn M. Abraham et al.   Circulation-Arrhythmia and Electrophysiology

Implications of the IQ-CSRC Prospective Study: Time to Revise ICH E14

(2015) Borje Darpo et al.   DRUG SAFETY

Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

(2015) J. Vicente et al.   Journal of the American Heart Association

Cardiac Safety Research Consortium: Can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward

(2014) Borje Darpo et al.   AMERICAN HEART JOURNAL

Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability

(2014) Tao Yang et al.   CIRCULATION

Exome Sequencing Implicates an Increased Burden of Rare Potassium Channel Variants in the Risk of Drug-Induced Long QT Interval Syndrome

(2014) Peter Weeke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

(2014) Dan E Arking et al.   NATURE GENETICS

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

Improving the Assessment of Heart Toxicity for All New Drugs Through Translational Regulatory Science

(2013) L Johannesen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Increased Persistent Sodium Current Due to Decreased PI3K Signaling Contributes to QT Prolongation in the Diabetic Heart

(2013) Z. Lu et al.   DIABETES

Impact of Genetics on the Clinical Management of Channelopathies

(2013) Peter J. Schwartz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes

(2013) Elijah R. Behr et al.   PLoS One

The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes

(2012) Elijah R. Behr et al.   EUROPEAN HEART JOURNAL

Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

(2012) Yalda Jamshidi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome

(2012) Z. Lu et al.   Science Translational Medicine

A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes

(2011) Stefan Kääb et al.   Circulation-Cardiovascular Genetics

Electrophysiologic basis for the antiarrhythmic actions of ranolazine

(2011) Charles Antzelevitch et al.   HEART RHYTHM

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Polymorphisms in the NOS1APGene Modulate QT Interval Duration and Risk of Arrhythmias in the Long QT Syndrome

(2010) Marta Tomás et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Variations in Nitric Oxide Synthase 1 Adaptor Protein Are Associated With Sudden Cardiac Death in US White Community-Based Populations

(2009) W.H. Linda Kao et al.   CIRCULATION

NOS1AP Is a Genetic Modifier of the Long-QT Syndrome

(2009) Lia Crotti et al.   CIRCULATION

Latent Genetic Backgrounds and Molecular Pathogenesis in Drug-Induced Long-QT Syndrome

(2009) Hideki Itoh et al.   Circulation-Arrhythmia and Electrophysiology

The Effect of Moxifloxacin on QTc and Implications for the Design of Thorough QT Studies

(2008) DM Bloomfield et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS