Calcium Release Channels: Structure and Function of IP3 Receptors and Ryanodine Receptors

The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246–Val4271 Reveals a Fifth Calcium Binding Site

(2021) Qinhong Yu et al.   BIOCHEMISTRY

Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2

(2021) Stefano Perni et al.   eLife

Resolved Structural States of Calmodulin in Regulation of Skeletal Muscle Calcium Release

(2020) Megan R. McCarthy et al.   BIOPHYSICAL JOURNAL

Crystal Structure of the Ryanodine Receptor SPRY2 Domain from the Diamondback Moth Provides Insights into the Development of Novel Insecticides

(2020) Yuanyuan Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist

(2020) Caleigh M. Azumaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor

(2020) Christian Holt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein

(2020) Horia Vais et al.   eLife

Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM

(2020) Kavita A. Iyer et al.   Science Advances

Structural basis for diamide modulation of ryanodine receptor

(2020) Ruifang Ma et al.   Nature Chemical Biology

The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia

(2020) Erron W. Titus et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

10 years of Cell Death & Disease

(2020) Mauro Piacentini et al.   Cell Death & Disease

Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel

(2019) Yanyu Zhao et al.   CELL

Type 3 inositol 1,4,5‐trisphosphate receptor is increased and enhances malignant properties in cholangiocarcinoma

(2019) Pimwipa Ueasilamongkol et al.   HEPATOLOGY

Dantrolene requires Mg2+ and ATP to inhibit the ryanodine receptor

(2019) Gyula Diszhazi et al.   MOLECULAR PHARMACOLOGY

Modulation of cardiac ryanodine receptor 2 by calmodulin

(2019) Deshun Gong et al.   NATURE

Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers

(2019) Daniela Rossi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A central core disease mutation in the Ca2+-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation

(2019) Venkat R. Chirasani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of cardiac ryanodine receptor calmodulin‐binding domains in mediating the action of arrhythmogenic calmodulin N‐domain mutation N54I

(2019) Mads T. Søndergaard et al.   FEBS Journal

Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators

(2019) Ximin Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malignant Hyperthermia in the Post-Genomics Era

(2018) Sheila Riazi et al.   ANESTHESIOLOGY

Pathophysiological consequences of isoform-specific IP 3 receptor mutations

(2018) Martijn Kerkhofs et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ryanodine receptor dysfunction in human disorders

(2018) Alexander Kushnir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Updated guide for the management of malignant hyperthermia

(2018) Sheila Riazi et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Stac proteins associate with the critical domain for excitation–contraction coupling in the II–III loop of CaV1.1

(2018) Alexander Polster et al.   JOURNAL OF GENERAL PHYSIOLOGY

Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes

(2018) Xi Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular Mechanism of Conductance Enhancement in Narrow Cation-Selective Membrane Channels

(2018) Williams E. Miranda et al.   Journal of Physical Chemistry Letters

Congenital myopathies: disorders of excitation–contraction coupling and muscle contraction

(2018) Heinz Jungbluth et al.   Nature Reviews Neurology

Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3

(2018) Navid Paknejad et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3

(2018) Navid Paknejad et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Calcium Channelopathies: Structural Insights into Disorders of the Muscle Excitation–Contraction Complex

(2018) Raika Pancaroglu et al.   Annual Review of Genetics

Influence of Lipid Mimetics on Gating of Ryanodine Receptor

(2018) Katrien Willegems et al.   STRUCTURE

Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels

(2018) Jacqueline Niu et al.   eLife

The insecticide chlorantraniliprole is a weak activator of mammalian skeletal ryanodine receptor/Ca2+ release channel

(2018) Jian Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IP3 receptors and Ca2+ entry

(2018) Nagendra Babu Thillaiappan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating

(2018) Guizhen Fan et al.   CELL RESEARCH

Ca2+-mediated activation of the skeletal-muscle ryanodine receptor ion channel

(2018) Le Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ryanodine Receptor 1-Related Myopathies: Diagnostic and Therapeutic Approaches

(2018) Tokunbor A. Lawal et al.   Neurotherapeutics

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel

(2018) Kaiqian Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant IP3 receptor activities revealed by comprehensive analysis of pathological mutations causing spinocerebellar ataxia 29

(2018) Hideaki Ando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of chlorantraniliprole and flubendiamide activity towards wild type and malignant hyperthermia-susceptible ryanodine receptors and heat stress intolerance

(2018) Kim M Truong et al.   TOXICOLOGICAL SCIENCES

Identification of novel and hotspot mutations in the channel domain of ITPR1 in two patients with Gillespie syndrome

(2017) Maria Lisa Dentici et al.   GENE

IP3 receptor mutations and brain diseases in human and rodents

(2017) Chihiro Hisatsune et al.   JOURNAL OF NEUROCHEMISTRY

A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns

(2017) Jillian P. Casey et al.   JOURNAL OF NEUROLOGY

Structural insights into binding of STAC proteins to voltage-gated calcium channels

(2017) Siobhan M. Wong King Yuen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+release

(2017) Stefano Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can the Arrangement of RyR2 in Cardiac Muscle Be Predicted?

(2016) Clara Franzini-Armstrong   BIOPHYSICAL JOURNAL

Ultrastructural Analysis of Self-Associated RyR2s

(2016) Vanessa Cabra et al.   BIOPHYSICAL JOURNAL

Structural Basis for Gating and Activation of RyR1

(2016) Amédée des Georges et al.   CELL

Ryanodine receptors under the magnifying lens: Insights and limitations of cryo-electron microscopy and X-ray crystallography studies

(2016) Zhiguang Yuchi et al.   CELL CALCIUM

How to open a Ryanodine Receptor

(2016) Filip Van Petegem   CELL RESEARCH

Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1

(2016) Risheng Wei et al.   CELL RESEARCH

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

(2016) Xiao-Chen Bai et al.   CELL RESEARCH

Spectrum and Prevalence ofCALM1-,CALM2-, andCALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141GCLINICAL PERSPECTIVE

(2016) Nicole J. Boczek et al.   Circulation-Cardiovascular Genetics

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex

(2016) Robyn T. Rebbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs

(2016) Rahul Chandrasekhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

(2016) Matthew L. Hedberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of sarcoplasmic reticulum Ca2+ release by serine-threonine phosphatases in the heart

(2016) Dmitry Terentyev et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs

(2016) David L. Prole et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

(2016) Jianping Wu et al.   NATURE

Stac3 has a direct role in skeletal muscle-type excitation–contraction coupling that is disrupted by a myopathy-causing mutation

(2016) Alexander Polster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Congenital myopathy results from misregulation of a muscle Ca2+channel by mutant Stac3

(2016) Jeremy W. Linsley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

Spectrum and Prevalence ofCALM1-,CALM2-, andCALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141GCLINICAL PERSPECTIVE

(2016) Nicole J. Boczek et al.   Circulation-Cardiovascular Genetics

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

CryoEM at IUCrJ: a new era

(2016) Sriram Subramaniam et al.   IUCrJ

Ca2+ microdomains organized by junctophilins

(2015) Hiroshi Takeshima et al.   CELL CALCIUM

Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view

(2015) Don-On Daniel Mak et al.   CELL CALCIUM

RYR1-related myopathies: a wide spectrum of phenotypes throughout life

(2015) M. Snoeck et al.   EUROPEAN JOURNAL OF NEUROLOGY

CALM3 mutation associated with long QT syndrome

(2015) Griffin J. Reed et al.   HEART RHYTHM

The EF-hand Ca2+Binding Domain Is Not Required for Cytosolic Ca2+Activation of the Cardiac Ryanodine Receptor

(2015) Wenting Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+Release

(2015) Mads T. Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermodynamics of Calcium binding to the Calmodulin N-terminal domain to evaluate site-specific affinity constants and cooperativity

(2015) Maria Rosa Beccia et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Gating machinery of InsP3R channels revealed by electron cryomicroscopy

(2015) Guizhen Fan et al.   NATURE

Structure of the voltage-gated calcium channel Cav1.1 complex

(2015) J. Wu et al.   SCIENCE

Structural basis of Sorcin-mediated calcium-dependent signal transduction

(2015) Andrea Ilari et al.   Scientific Reports

Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms

(2014) Kelvin Lau et al.   BIOCHEMISTRY

Selecting Ions by Size in a Calcium Channel: The Ryanodine Receptor Case Study

(2014) Dirk Gillespie et al.   BIOPHYSICAL JOURNAL

Toward a high-resolution structure of IP3R channel

(2014) Irina I. Serysheva   CELL CALCIUM

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

(2014) Hyun Seok Hwang et al.   CIRCULATION RESEARCH

Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias

(2014) Steven R. Houser   CIRCULATION RESEARCH

Abolished InsP3R2 function inhibits sweat secretion in both humans and mice

(2014) Joakim Klar et al.   JOURNAL OF CLINICAL INVESTIGATION

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes

(2014) Worawan B. Limpitikul et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury

(2014) Mariano N. Di Carlo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

(2014) Zhen Yan et al.   NATURE

Architecture and conformational switch mechanism of the ryanodine receptor

(2014) Rouslan G. Efremov et al.   NATURE

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

(2014) Wenqian Chen et al.   NATURE MEDICINE

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1

(2013) Naohiro Yamaguchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca2+release and destabilizes the N-terminal domains

(2013) Yingjie Liu et al.   BIOCHEMICAL JOURNAL

Ca2+ homeostasis in the endoplasmic reticulum measured with a new low-Ca2+-affinity targeted aequorin

(2013) Sergio de la Fuente et al.   CELL CALCIUM

Calmodulin Mutations Associated With Recurrent Cardiac Arrest in Infants

(2013) Lia Crotti et al.   CIRCULATION

Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy

(2013) Fernando J. Amador et al.   JOURNAL OF MOLECULAR BIOLOGY

Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107

(2013) Yingwu Mei et al.   PLoS One

CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions

(2013) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Domain cooperativity in the  1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle

(2013) A. Dayal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations

(2013) Lynn Kimlicka et al.   STRUCTURE

Is ryanodine receptor a calcium or magnesium channel? Roles of K+ and Mg2+ during Ca2+ release

(2012) Dirk Gillespie et al.   CELL CALCIUM

Ryanodine Receptor S2808 Phosphorylation in Heart Failure

(2012) Donald M. Bers   CIRCULATION RESEARCH

Role of RyR2 Phosphorylation at S2814 During Heart Failure Progression

(2012) Jonathan L. Respress et al.   CIRCULATION RESEARCH

Aniridia

(2012) Melanie Hingorani et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Structural determination of the phosphorylation domain of the ryanodine receptor

(2012) Parveen Sharma et al.   FEBS Journal

Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy

(2012) Sameer Ather et al.   HEART RHYTHM

High-capacity Ca2+Binding of Human Skeletal Calsequestrin

(2012) Emiliano J. Sanchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional conservation of key domains in InsP3 and ryanodine receptors

(2012) Min-Duk Seo et al.   NATURE

Calsequestrin Mutations and Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Michela Faggioni et al.   PEDIATRIC CARDIOLOGY

Disease Mutations in the Ryanodine Receptor Central Region: Crystal Structures of a Phosphorylation Hot Spot Domain

(2012) Zhiguang Yuchi et al.   STRUCTURE

Functional characterization of the P1059L mutation in the inositol 1,4,5-trisphosphate receptor type 1 identified in a Japanese SCA15 family

(2011) Haruka Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ryanodine receptor type 1 gene mutations found in the Canadian malignant hyperthermia population

(2011) Natasha Kraeva et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Enhanced ER Ca2+ store filling by overexpression of SERCA2b promotes IP3-evoked puffs

(2011) Michiko Yamasaki-Mann et al.   CELL CALCIUM

Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

(2011) Daniel C. Andersson et al.   Cell Metabolism

A Novel Ryanodine Receptor Mutation Linked to Sudden Death Increases Sensitivity to Cytosolic Calcium

(2011) Albano C. Meli et al.   CIRCULATION RESEARCH

Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis

(2011) Silvia G. Priori et al.   CIRCULATION RESEARCH

Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice

(2011) Na Li et al.   CIRCULATION RESEARCH

Positive Forcings in Climate-Change Pedagogy

(2011) Jennifer S. Lalley   CONSERVATION BIOLOGY

Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor

(2011) Chun-Chi Lin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Trisk 32 regulates IP3 receptors in rat skeletal myoblasts

(2011) Tamás Oláh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium

(2011) T. Shinohara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural biology of ryanodine receptors

(2011) Lynn Kimlicka et al.   Science China-Life Sciences

Flexible Architecture of IP3R1 by Cryo-EM

(2011) Steven J. Ludtke et al.   STRUCTURE

The Deletion of Exon 3 in the Cardiac Ryanodine Receptor Is Rescued by β Strand Switching

(2011) Paolo A. Lobo et al.   STRUCTURE

The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma

(2010) Kazunori Shibao et al.   CELL CALCIUM

Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks

(2010) Tao Guo et al.   CIRCULATION RESEARCH

Mapping the Ryanodine Receptor FK506-binding Protein Subunit Using Fluorescence Resonance Energy Transfer

(2010) Razvan L. Cornea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyr-167/Trp-168 in Type 1/3 Inositol 1,4,5-Trisphosphate Receptor Mediates Functional Coupling between Ligand Binding and Channel Opening

(2010) Haruka Yamazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule

(2010) Ching-Chieh Tung et al.   NATURE

Ryanodine receptor channelopathies

(2010) Matthew J. Betzenhauser et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genetic Characterization of Familial CPVT After 30 Years

(2009) T. A. Beery et al.   Biological Research for Nursing

Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation

(2009) Veerle Vanderheyden et al.   CELL CALCIUM

Ca2+ signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin

(2009) Nicole A. Beard et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Protein Kinase A Increases Type-2 Inositol 1,4,5-Trisphosphate Receptor Activity by Phosphorylation of Serine 937

(2009) Matthew J. Betzenhauser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of type I ryanodine receptor amino-terminal  -trefoil domain reveals a disease-associated mutation "hot spot" loop

(2009) F. J. Amador et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of the N-Terminal Domains of Cardiac and Skeletal Muscle Ryanodine Receptors: Insights into Disease Mutations

(2009) Paolo Antonio Lobo et al.   STRUCTURE

Native American myopathy: Congenital myopathy with cleft palate, skeletal anomalies, and susceptibility to malignant hyperthermia

(2008) Demetra S. Stamm et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes

(2008) Sabine Huke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Localization of PKA phosphorylation site, Ser2030, in the three-dimensional structure of cardiac ryanodine receptor

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation

(2008) Veerle Vanderheyden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Anomalous Mole Fraction Effect in Calcium Channels: A Measure of Preferential Selectivity

(2008) Dirk Gillespie et al.   BIOPHYSICAL JOURNAL

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts

(2008) H. Tateishi et al.   CARDIOVASCULAR RESEARCH

Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs

(2008) Junya Ito et al.   DEVELOPMENTAL BIOLOGY

Reduced Threshold for Luminal Ca2+Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia

(2008) Dawei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Ca2+-dependent Regulation of Inositol 1,4,5-Trisphosphate Receptors by CaBP1

(2008) Congmin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proper Restoration of Excitation-Contraction Coupling in the Dihydropyridine Receptor β1-null ZebrafishRelaxedIs an Exclusive Function of the β1aSubunit

(2008) Johann Schredelseker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S100A1 and Calmodulin Compete for the Same Binding Site on Ryanodine Receptor

(2008) Nathan T. Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Luminal Mg2+, A Key Factor Controlling RYR2-mediated Ca2+Release: Cytoplasmic and Luminal Regulation Modeled in a Tetrameric Channel

(2008) Derek R. Laver et al.   JOURNAL OF GENERAL PHYSIOLOGY

Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families

(2008) K. Hara et al.   NEUROLOGY

Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel

(2008) I. I. Serysheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arrhythmogenic Right Ventricular Dysplasia

(2008) Palaniappan Muthappan et al.   PROGRESS IN CARDIOVASCULAR DISEASES