Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+Release

Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

(2015) Mads T. Søndergaard et al.   FEBS Journal

Ryanodine Receptors: Allosteric Ion Channel Giants

(2015) Filip Van Petegem   JOURNAL OF MOLECULAR BIOLOGY

The cardiac ryanodine receptor luminal Ca2+sensor governs Ca2+waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice

(2014) Jingqun Zhang et al.   BIOCHEMICAL JOURNAL

Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms

(2014) Kelvin Lau et al.   BIOCHEMISTRY

Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

(2014) Hyun Seok Hwang et al.   CIRCULATION RESEARCH

Novel Calmodulin Mutations Associated With Congenital Arrhythmia Susceptibility

(2014) N. Makita et al.   Circulation-Cardiovascular Genetics

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes

(2014) Worawan B. Limpitikul et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

(2014) Wenqian Chen et al.   NATURE MEDICINE

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+release

(2013) Xixi Tian et al.   BIOCHEMICAL JOURNAL

Calmodulin Mutations Associated With Recurrent Cardiac Arrest in Infants

(2013) Lia Crotti et al.   CIRCULATION

Cardiac Myocyte Z-Line Calmodulin Is Mainly RyR2-Bound, and Reduction Is Arrhythmogenic and Occurs in Heart Failure

(2013) Yi Yang et al.   CIRCULATION RESEARCH

Calmodulin in a Heartbeat

(2013) Anders B. Sorensen et al.   FEBS Journal

Two potential calmodulin-binding sequences in the ryanodine receptor contribute to a mobile, intra-subunit calmodulin-binding domain

(2013) X. Huang et al.   JOURNAL OF CELL SCIENCE

Long QT syndrome: beyond the causal mutation

(2013) Ahmad S. Amin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor

(2013) Juan José Arnáiz-Cot et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Mutation in CALM1 Encoding Calmodulin in Familial Idiopathic Ventricular Fibrillation in Childhood and Adolescence

(2013) Roos F. Marsman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death

(2012) Mette Nyegaard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

In Cardiomyocytes, Binding of Unzipping Peptide Activates Ryanodine Receptor 2 and Reciprocally Inhibits Calmodulin Binding

(2012) Tetsuro Oda et al.   CIRCULATION RESEARCH

Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human

(2012) Nathalie Roux-Buisson et al.   HUMAN MOLECULAR GENETICS

Calmodulin-binding Locations on the Skeletal and Cardiac Ryanodine Receptors

(2012) Xiaojun Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ryanodine Receptors: Structure and Function

(2012) Filip Van Petegem   JOURNAL OF BIOLOGICAL CHEMISTRY

Inherited calcium channelopathies in the pathophysiology of arrhythmias

(2012) Luigi Venetucci et al.   Nature Reviews Cardiology

Thermodynamic linkage between calmodulin domains binding calcium and contiguous sites in the C-terminal tail of CaV1.2

(2011) T. Idil Apak Evans et al.   BIOPHYSICAL CHEMISTRY

FRET Detection of Calmodulin Binding to the Cardiac RyR2 Calcium Release Channel

(2011) Tao Guo et al.   BIOPHYSICAL JOURNAL

Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis

(2011) Silvia G. Priori et al.   CIRCULATION RESEARCH

The structural biology of ryanodine receptors

(2011) Lynn Kimlicka et al.   Science China-Life Sciences

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

(2010) Xiaojuan Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Site-specific modification of calmodulin Ca2+affinity tunes the skeletal muscle ryanodine receptor activation profile

(2010) Jie Jiang et al.   BIOCHEMICAL JOURNAL

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure

(2010) Makoto Ono et al.   CARDIOVASCULAR RESEARCH

Intermolecular tuning of calmodulin by target peptides and proteins: Differential effects on Ca2+ binding and implications for kinase activation

(2010) Olve B. Peersen et al.   PROTEIN SCIENCE

Endoplasmic reticulum Ca2+measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+release

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL

Intracellular Ca Alternans: Coordinated Regulation by Sarcoplasmic Reticulum Release, Uptake, and Leak

(2008) Lai-Hua Xie et al.   BIOPHYSICAL JOURNAL

Termination of Cardiac Ca 2+ Sparks

(2008) Aleksey V. Zima et al.   CIRCULATION RESEARCH