Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels

STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex

(2018) Eutteum Jeong et al.   CELL DEATH AND DIFFERENTIATION

Dstac is required for normal circadian activity rhythms in Drosophila

(2018) I-Uen Hsu et al.   CHRONOBIOLOGY INTERNATIONAL

Stac3 enhances expression of human CaV1.1 inXenopusoocytes and reveals gating pore currents in HypoPP mutant channels

(2018) Fenfen Wu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Duplex signaling by CaM and Stac3 enhances CaV1.1 function and provides insights into congenital myopathy

(2018) Jacqueline Niu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Stac proteins associate with the critical domain for excitation–contraction coupling in the II–III loop of CaV1.1

(2018) Alexander Polster et al.   JOURNAL OF GENERAL PHYSIOLOGY

STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation

(2018) Marta Campiglio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The chemical basis for electrical signaling

(2017) William A Catterall et al.   Nature Chemical Biology

The Mechanisms and Functions of Synaptic Facilitation

(2017) Skyler L. Jackman et al.   NEURON

Structural insights into binding of STAC proteins to voltage-gated calcium channels

(2017) Siobhan M. Wong King Yuen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of the alpha subunit of the voltage gated L-type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles

(2017) Jeremy W. Linsley et al.   TRAFFIC

STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triads

(2017) Marta Campiglio et al.   Scientific Reports

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

(2016) Jianping Wu et al.   NATURE

Calcium sensor regulation of the CaV2.1 Ca2+channel contributes to short-term synaptic plasticity in hippocampal neurons

(2016) Evanthia Nanou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stac3 has a direct role in skeletal muscle-type excitation–contraction coupling that is disrupted by a myopathy-causing mutation

(2016) Alexander Polster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Congenital myopathy results from misregulation of a muscle Ca2+channel by mutant Stac3

(2016) Jeremy W. Linsley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins

(2016) Geoffrey S. Pitt et al.   PROTEIN SCIENCE

Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure

(2016) David S. Park et al.   Nature Communications

Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum

(2015) Christopher B. Marshall et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small-conductance Ca2+-activated K+ channels and cardiac arrhythmias

(2015) Xiao-Dong Zhang et al.   HEART RHYTHM

Right Ventricular Myocardial Biomarkers in Human Heart Failure

(2015) Thomas G. di Salvo et al.   JOURNAL OF CARDIAC FAILURE

Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance

(2015) M. K. Bosch et al.   JOURNAL OF NEUROSCIENCE

Characterization of the Transcriptome of Nascent Hair Cells and Identification of Direct Targets of the Atoh1 Transcription Factor

(2015) T. Cai et al.   JOURNAL OF NEUROSCIENCE

Large Ca2+-dependent facilitation of CaV2.1 channels revealed by Ca2+photo-uncaging

(2015) Shin-Rong Lee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

(2015) Gerald W. Zamponi   NATURE REVIEWS DRUG DISCOVERY

Cell-type-specific tuning of Cav1.3 Ca2+-channels by a C-terminal automodulatory domain

(2015) Anja Scharinger et al.   Frontiers in Cellular Neuroscience

Transcriptional Profiling of Hypoxic Neural Stem Cells Identifies Calcineurin-NFATc4 Signaling as a Major Regulator of Neural Stem Cell Biology

(2015) Marta Moreno et al.   Stem Cell Reports

Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing

(2015) Mei-ling Joiner et al.   Current Molecular Pharmacology

Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels

(2015) Manu Ben-Johny et al.   Current Molecular Pharmacology

Conservation of Ca2+/Calmodulin Regulation across Na and Ca2+ Channels

(2014) Manu Ben-Johny et al.   CELL

Apocalmodulin Itself Promotes Ion Channel Opening and Ca2+ Regulation

(2014) Paul J. Adams et al.   CELL

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes

(2014) Worawan B. Limpitikul et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

Allostery in Ca2+ channel modulation by calcium-binding proteins

(2014) Philemon S Yang et al.   Nature Chemical Biology

Fibroblast Growth Factor Homologous Factors

(2014) Juan L. Pablo et al.   NEUROSCIENTIST

Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+channels

(2014) Alexander Polster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the NaV1.5 cytoplasmic domain by calmodulin

(2014) Sandra B. Gabelli et al.   Nature Communications

Structural analyses of Ca2+/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation

(2014) Chaojian Wang et al.   Nature Communications

FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons

(2014) Haidun Yan et al.   eLife

A new variable phenotype in spinocerebellar ataxia 27 (SCA 27) caused by a deletion in the FGF14 gene

(2013) J.A. Coebergh et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

FGF12 is a candidate Brugada syndrome locus

(2013) Jessica A. Hennessey et al.   HEART RHYTHM

Competitive and Non-competitive Regulation of Calcium-dependent Inactivation in CaV1.2 L-type Ca2+Channels by Calmodulin and Ca2+-binding Protein 1

(2013) Shimrit Oz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional plasticity in long-term cultures of adult ventricular myocytes

(2013) Rosy Joshi-Mukherjee et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Competition between α-actinin and Ca2+-Calmodulin Controls Surface Retention of the L-type Ca2+ Channel CaV1.2

(2013) Duane D. Hall et al.   NEURON

Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility

(2013) B. R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stac3 is a component of the excitation–contraction coupling machinery and mutated in Native American myopathy

(2013) Eric J. Horstick et al.   Nature Communications

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

(2013) Manu Ben Johny et al.   Nature Communications

Continuously Tunable Ca2+ Regulation of RNA-Edited CaV1.3 Channels

(2013) Hojjat Bazzazi et al.   Cell Reports

Seeing the Forest through the Trees: towards a Unified View on Physiological Calcium Regulation of Voltage-Gated Sodium Channels

(2012) Filip Van Petegem et al.   BIOPHYSICAL JOURNAL

Localized Calcineurin Confers Ca2+-Dependent Inactivation on Neuronal L-Type Ca2+ Channels

(2012) S. F. Oliveria et al.   JOURNAL OF NEUROSCIENCE

Inherited calcium channelopathies in the pathophysiology of arrhythmias

(2012) Luigi Venetucci et al.   Nature Reviews Cardiology

RNA Editing of the IQ Domain in Cav1.3 Channels Modulates Their Ca2+-Dependent Inactivation

(2012) Hua Huang et al.   NEURON

Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin

(2012) Chaojian Wang et al.   STRUCTURE

Fibroblast Growth Factor Homologous Factors in the Heart: A Potential Locus for Cardiac Arrhythmias

(2012) Eric Q. Wei et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Nanodomain Ca2+ of Ca2+ channels detected by a tethered genetically encoded Ca2+ sensor

(2012) Lai Hock Tay et al.   Nature Communications

Altered sodium channel-protein associations in critical illness myopathy

(2012) Susan D Kraner et al.   Skeletal Muscle

Fibroblast Growth Factor Homologous Factor 13 Regulates Na + Channels and Conduction Velocity in Murine Hearts

(2011) Chuan Wang et al.   CIRCULATION RESEARCH

Functional Properties of a Newly Identified C-terminal Splice Variant of Cav1.3 L-type Ca2+Channels

(2011) Gabriella Bock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Characterization of Alternative Splicing in the C Terminus of L-type CaV1.3 Channels

(2011) Bao Zhen Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Splicing at C Terminus of CaV1.4 Calcium Channel Modulates Calcium-dependent Inactivation, Activation Potential, and Current Density

(2011) Gregory Ming Yeong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel Interaction Sites that Determine Specificity between Fibroblast Growth Factor Homologous Factors and Voltage-gated Sodium Channels

(2011) Chaojian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation

(2010) Felix Findeisen et al.   Channels

stac1 and stac2 genes define discrete and distinct subsets of dorsal root ganglia neurons

(2010) Wassim Legha et al.   GENE EXPRESSION PATTERNS

Long-term inactivation particle for voltage-gated sodium channels

(2010) Katarzyna Dover et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin

(2010) Xiaodong Liu et al.   NATURE

Organelle-specific, rapid induction of molecular activities and membrane tethering

(2010) Toru Komatsu et al.   NATURE METHODS

Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels

(2010) Jörg Striessnig et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel

(2010) P. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Differential Effects of CaBP1 and Calmodulin on CaV1.2 Calcium-Dependent Inactivation

(2010) Felix Findeisen et al.   STRUCTURE

Modulation of Voltage- and Ca2+-dependent Gating of CaV1.3 L-type Calcium Channels by Alternative Splicing of a C-terminal Regulatory Domain

(2008) Anamika Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCN5A channelopathies – An update on mutations and mechanisms

(2008) Thomas Zimmer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Crystal Structure of the CaV2 IQ Domain in Complex with Ca2+/Calmodulin: High-Resolution Mechanistic Implications for Channel Regulation by Ca2+

(2008) Masayuki X. Mori et al.   STRUCTURE

Modifying L-Type Calcium Current Kinetics: Consequences for Cardiac Excitation and Arrhythmia Dynamics

(2007) Aman Mahajan et al.   BIOPHYSICAL JOURNAL