Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM

The FKBP12 subunit modifies the long-range allosterism of the ryanodine receptor

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Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

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EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2

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Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs

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Extensive Ca2+leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+hypersensitivity

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The structural basis of ryanodine receptor ion channel function

(2017) Gerhard Meissner   JOURNAL OF GENERAL PHYSIOLOGY

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cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

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A cryo-EM–based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor

(2017) Sonali Dhindwal et al.   Science Signaling

A cryo-EM–based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor

(2017) Sonali Dhindwal et al.   Science Signaling

Ultrastructural Analysis of Self-Associated RyR2s

(2016) Vanessa Cabra et al.   BIOPHYSICAL JOURNAL

Structural Basis for Gating and Activation of RyR1

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The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

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Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel

(2016) Takashi Murayama et al.   HUMAN MUTATION

A guide to the 3D structure of the ryanodine receptor type 1 by cryoEM

(2016) Montserrat Samsó   PROTEIN SCIENCE

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

(2016) Wei Peng et al.   SCIENCE

Multiple mutations of lung squamous cell carcinoma shared common mechanisms

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Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region

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Myoplasmic resting Ca2+regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor

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Architecture and conformational switch mechanism of the ryanodine receptor

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Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

(2014) Junji Suzuki et al.   Nature Communications

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain

(2014) Kelvin Lau et al.   Nature Communications

Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy

(2013) Fernando J. Amador et al.   JOURNAL OF MOLECULAR BIOLOGY

Altered Ca2+concentration, permeability and buffering in the myofibre Ca2+store of a mouse model of malignant hyperthermia

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Likelihood-based classification of cryo-EM images using FREALIGN

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Quantifying the local resolution of cryo-EM density maps

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Collaboration gets the most out of software

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RELION: Implementation of a Bayesian approach to cryo-EM structure determination

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An Expanded Palette of Genetically Encoded Ca2+ Indicators

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Features and development ofCoot

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A malignant hyperthermia–inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels

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A malignant hyperthermia–inducing mutation in RYR1 (R163C): alterations in Ca2+entry, release, and retrograde signaling to the DHPR

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Functional and Biochemical Properties of Ryanodine Receptor Type 1 Channels from Heterozygous R163C Malignant Hyperthermia-Susceptible Mice

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Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

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SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs

(2009) Tanvir R Shaikh et al.   Nature Protocols

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating

(2009) Montserrat Samsó et al.   PLOS BIOLOGY

Arrhythmogenic Right Ventricular Dysplasia

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