Oxidative Stress as a Common Key Event in Developmental Neurotoxicity

The impact of glutathione metabolism in autism spectrum disorder

(2021) Geir Bjørklund et al.   PHARMACOLOGICAL RESEARCH

Attention-deficit hyperactivity disorder

(2020) Jonathan Posner et al.   LANCET

Using machine learning methods and structural alerts for prediction of mitochondrial toxicity

(2020) Jennifer Hemmerich et al.   Molecular Informatics

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

(2020) Jonathan A. Hollander et al.   NEUROPSYCHOPHARMACOLOGY

Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain

(2020) Yiying Zhang et al.   Frontiers in Cell and Developmental Biology

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

(2020) Sabina Halappanavar et al.   Particle and Fibre Toxicology

The role of NADPH oxidases in neuronal development

(2020) Aslihan Terzi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of glutathione redox imbalance in autism spectrum disorder: A review

(2020) Geir Bjørklund et al.   FREE RADICAL BIOLOGY AND MEDICINE

An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches

(2020) Martin Paparella et al.   REPRODUCTIVE TOXICOLOGY

Predicting oxidative stress induced by organic chemicals by using quantitative Structure–Activity relationship methods

(2020) Shengnan Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and glial cells

(2020) Emma Di Consiglio et al.   REPRODUCTIVE TOXICOLOGY

Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines

(2020) Shotaro Kamata et al.   TOXICOLOGY IN VITRO

The Neuroprotective Effect of Hemin and the Related Mechanism in Sevoflurane Exposed Neonatal Rats

(2019) Fan Yang et al.   Frontiers in Neuroscience

An industry perspective: A streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity

(2019) Jinpeng Li et al.   NEUROTOXICOLOGY

Vitexin inhibits acrylamide-induced neuroinflammation and improves behavioral changes in zebrafish larvae

(2019) Manigandan Krishnan et al.   NEUROTOXICOLOGY AND TERATOLOGY

Neuroinflammation as a risk factor for attention deficit hyperactivity disorder

(2019) Geoffrey A. Dunn et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Development and analysis of an adverse outcome pathway network for human neurotoxicity

(2019) Nicoleta Spinu et al.   ARCHIVES OF TOXICOLOGY

Sex influences in the preventive effects of N-acetylcysteine in a two-hit animal model of schizophrenia

(2019) Aline Santos Monte et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Drug transport across the human placenta: review of placenta-on-a-chip and previous approaches

(2019) Rajeendra L. Pemathilaka et al.   Interface Focus

Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts

(2019) Ainhoa Jorcano et al.   ENVIRONMENT INTERNATIONAL

A pharmacokinetic model of lead absorption and calcium competitive dynamics

(2019) Anca Rădulescu et al.   Scientific Reports

Exposure of Developing Brain to General Anesthesia

(2018) Vesna Jevtovic-Todorovic   ANESTHESIOLOGY

Developmental Neurotoxicity of Arsenic: Involvement of Oxidative Stress and Mitochondrial Functions

(2018) Lalit P. Chandravanshi et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Biochemical, Oxidative, and Physiological Changes Caused by Acute Exposure of Fentanyl and Its 3 Analogs in Rodents

(2018) Shiv Kumar Yadav et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation

(2018) Wan-Yu Huang et al.   Journal of Neuroinflammation

Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: Focus on biological pathways and epigenetic mechanisms

(2018) Nadia Cattane et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

From birth to death: A role for reactive oxygen species in neuronal development

(2018) Carlos Wilson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Development of the concept for stem cell-based Developmental Neurotoxicity (DNT) evaluation

(2018) Ellen Fritsche et al.   TOXICOLOGICAL SCIENCES

A better approach to in vivo developmental neurotoxicity assessment: Alignment of rodent testing with effects seen in children after neurotoxic exposures

(2018) Charles V. Vorhees et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells

(2018) Shigeru Yamada et al.   Scientific Reports

Zebrafish Models of Neurodevelopmental Disorders: Past, Present, and Future

(2018) Catalina Sakai et al.   Frontiers in Molecular Neuroscience

The contribution of environmental exposure to the etiology of autism spectrum disorder

(2018) Sven Bölte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies

(2018) Simon C. Johnson et al.   NEUROTOXICOLOGY AND TERATOLOGY

Molecular Pathology and Pharmacological Treatment of Autism Spectrum Disorder-Like Phenotypes Using Rodent Models

(2018) Hsiao-Ying Kuo et al.   Frontiers in Cellular Neuroscience

Vitamin E reduces endosulfan-induced toxic effects on morphology and behavior in early development of zebrafish ( Danio rerio )

(2017) K. Dale et al.   FOOD AND CHEMICAL TOXICOLOGY

Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes

(2017) Francesca Pistollato et al.   NEUROCHEMISTRY INTERNATIONAL

Environmental toxicology: Sensitive periods of development and neurodevelopmental disorders

(2017) Djai B. Heyer et al.   NEUROTOXICOLOGY

Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and Non-Energy-Related Mechanisms

(2017) Keren K. Griffiths et al.   Oxidative Medicine and Cellular Longevity

In vitro to in vivo extrapolation of effective dosimetry in developmental toxicity testing: Application of a generic PBK modelling approach

(2017) Styliani Fragki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

(2017) David Pamies   ALTEX-Alternatives to Animal Experimentation

Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by p38 MAPK Pathway

(2017) Tianguang Zhang et al.   Frontiers in Pharmacology

Inhibiting NADPH oxidase protects against long-term memory impairment induced by neonatal sevoflurane exposure in mice

(2016) Z. Sun et al.   BRITISH JOURNAL OF ANAESTHESIA

Toward the Design of Less Hazardous Chemicals: Exploring Comparative Oxidative Stress in Two Common Animal Models

(2016) Jone Corrales et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Arsenic-induced mitochondrial oxidative damage is mediated by decreased PGC-1α expression and its downstream targets in rat brain

(2016) Chandra Prakash et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

(2016) Yang Zeng et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Schizophrenia

(2016) Michael J Owen et al.   LANCET

Defining potential roles of Pb2+in neurotoxicity from a calciomics approach

(2016) Rakshya Gorkhali et al.   Metallomics

Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health

(2016) Jacqueline Michelle Ordemann et al.   Metallomics

Sex- and structure-specific differences in antioxidant responses to methylmercury during early development

(2016) Joanna A. Ruszkiewicz et al.   NEUROTOXICOLOGY

Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells

(2016) Junko Yamane et al.   NUCLEIC ACIDS RESEARCH

An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy

(2016) Paul Brownbill et al.   REPRODUCTIVE TOXICOLOGY

Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders

(2016) Francesco Petrelli et al.   Frontiers in Cellular Neuroscience

DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina

(2016) Shota Sasagawa et al.   Frontiers in Pharmacology

Computational Models of Reactive Oxygen Species as Metabolic Byproducts and Signal-Transduction Modulators

(2016) Elizabeth J. Pereira et al.   Frontiers in Pharmacology

In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish

(2015) Shota Sasagawa et al.   ACS Chemical Biology

Mitochondrial Redox Dysfunction and Environmental Exposures

(2015) Samuel W. Caito et al.   ANTIOXIDANTS & REDOX SIGNALING

Computational modeling analysis of mitochondrial superoxide production under varying substrate conditions and upon inhibition of different segments of the electron transport chain

(2015) Nikolai I. Markevich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Zebrafish as a systems toxicology model for developmental neurotoxicity testing

(2015) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Putative adverse outcome pathways relevant to neurotoxicity

(2015) Anna Bal-Price et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mitochondrial oxidative stress and dysfunction in arsenic neurotoxicity: A review

(2015) Chandra Prakash et al.   JOURNAL OF APPLIED TOXICOLOGY

Only humans have human placentas: molecular differences between mice and humans

(2015) André Schmidt et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Transcriptional and post-transcriptional regulation of transmembrane protein 132A

(2015) Kentaro Oh-hashi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice

(2015) Mu-Huo Ji et al.   NEUROTOXICOLOGY

Melatonin ameliorates oxidative damage induced by maternal lead exposure in rat pups

(2015) Maryam Bazrgar et al.   PHYSIOLOGY & BEHAVIOR

Zebrafish as a systems toxicology model for developmental neurotoxicity testing

(2015) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Perinatal Exposure to Lead: Reduction in Alterations of Brain Mitochondrial Antioxidant System with Calcium Supplement

(2014) Rajarami Reddy Gottipolu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Advances in the development of novel antioxidant therapies as an approach for fetal alcohol syndrome prevention

(2014) Xavier Joya et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: a prospective birth cohort study

(2014) CM Taylor et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Oxidative stress and schizophrenia

(2014) Francesco E. Emiliani et al.   CURRENT OPINION IN PSYCHIATRY

Stem cells and the impact of ROS signaling

(2014) C. L. Bigarella et al.   DEVELOPMENT

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Maternal lifestyle and environmental risk factors for autism spectrum disorders

(2014) Kristen Lyall et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mitochondria: hub of injury responses in the developing brain

(2014) Henrik Hagberg et al.   LANCET NEUROLOGY

Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats

(2014) Pranay Srivastava et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Comparison of the Different Animal Models of Fetal Alcohol Spectrum Disorders and Their Use in Studying Complex Behaviors

(2014) Anna R. Patten et al.   Frontiers in Pediatrics

Early Exposure to General Anesthesia Disturbs Mitochondrial Fission and Fusion in the Developing Rat Brain

(2013) Annalisa Boscolo et al.   ANESTHESIOLOGY

Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: Reversal effect of essential metals and a chelating agent

(2013) Praveen Kumar Kadeyala et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Autism

(2013) Meng-Chuan Lai et al.   LANCET

Methylmercury impairs motor function in early development and induces oxidative stress in cerebellar granule cells

(2013) Eshan Patel et al.   TOXICOLOGY LETTERS

Developmental neurotoxicity testing: Scientific approaches towards the next generation to protect the developing nervous system of children. An overview of the Developmental Neurotoxicity Symposium in 2011

(2012) Hiroaki Aoyama   CONGENITAL ANOMALIES

DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson’s disease

(2011) Xinglong Wang et al.   AGING CELL

Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead

(2011) Irena Baranowska-Bosiacka et al.   BRAIN RESEARCH

Reactive oxygen species and the neuronal fate

(2011) Karen A. M. Kennedy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multi-Parametric Profiling Network Based on Gene Expression and Phenotype Data: A Novel Approach to Developmental Neurotoxicity Testing

(2011) Reiko Nagano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

(2011) F. Jiang et al.   PHARMACOLOGICAL REVIEWS

MiADMSA reverses impaired mitochondrial energy metabolism and neuronal apoptotic cell death after arsenic exposure in rats

(2011) Nidhi Dwivedi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain

(2010) Ansgar M. Brambrink et al.   ANESTHESIOLOGY

An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays

(2010) Thomas E. Gunter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice

(2009) Maiko Satomoto et al.   ANESTHESIOLOGY

Subchronic exposure to arsenic decreased Sdha expression in the brain of mice

(2009) Yan Hong et al.   NEUROTOXICOLOGY

Learning deficits in C57BL/6J mice following perinatal arsenic exposure: Consequence of lower corticosterone receptor levels?

(2009) Ebany J. Martinez-Finley et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos

(2009) Jian Dong et al.   TOXICOLOGY LETTERS

Relation between Cord Blood Mercury Levels and Early Child Development in a World Trade Center Cohort

(2008) Sally Ann Lederman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Biomarkers of oxidative stress and damage in human populations exposed to arsenic

(2008) Andrea De Vizcaya-Ruiz et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS