DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina

Using zebrafish in systems toxicology for developmental toxicity testing

(2016) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Using zebrafish in systems toxicology for developmental toxicity testing

(2016) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish

(2015) Shota Sasagawa et al.   ACS Chemical Biology

Zebrafish as a systems toxicology model for developmental neurotoxicity testing

(2015) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

DNA Damage, Poly(ADP-Ribose) Polymerase Activation, and Phosphorylated Histone H2AX Expression During Postnatal Retina Development in C57BL/6 Mouse

(2015) D. Martin-Oliva et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity

(2015) Mamta Behl et al.   NEUROTOXICOLOGY AND TERATOLOGY

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

(2015) Marianne S. Poruchynsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish as a systems toxicology model for developmental neurotoxicity testing

(2015) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity

(2015) Yuhei Nishimura et al.   Frontiers in Pharmacology

Triclabendazole Sulfoxide Causes Stage-Dependent Embryolethality in Zebrafish and Mouse In Vitro

(2015) Nuria Boix et al.   PLoS One

Systems Toxicology: From Basic Research to Risk Assessment

(2014) Shana J. Sturla et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pregnancy and helminth infections

(2014) H. Mpairwe et al.   PARASITE IMMUNOLOGY

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

(2014) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Identification of a Novel Indoline Derivative for in Vivo Fluorescent Imaging of Blood-Brain Barrier Disruption in Animal Models

(2013) Yuhei Nishimura et al.   ACS Chemical Neuroscience

JEPETTO: a Cytoscape plugin for gene set enrichment and topological analysis based on interaction networks

(2013) Charles Winterhalter et al.   BIOINFORMATICS

CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data

(2013) Gabriela Bindea et al.   BIOINFORMATICS

Mechanisms That Enhance Sustainability of p53 Pulses

(2013) Jae Kyoung Kim et al.   PLoS One

Nbn and Atm Cooperate in a Tissue and Developmental Stage-Specific Manner to Prevent Double Strand Breaks and Apoptosis in Developing Brain and Eye

(2013) Paulo M. G. Rodrigues et al.   PLoS One

Hydroxyurea Exposure Triggers Tissue-Specific Activation of p38 Mitogen-Activated Protein Kinase Signaling and the DNA Damage Response in Organogenesis-Stage Mouse Embryos

(2013) Serena Banh et al.   TOXICOLOGICAL SCIENCES

Toxicity of 15 veterinary pharmaceuticals in zebrafish (Danio rerio) embryos

(2012) Gunnar Carlsson et al.   AQUATIC TOXICOLOGY

In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish

(2012) Kohei Watanabe et al.   BMC NEUROSCIENCE

Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

(2012) Moumita Chaki et al.   CELL

ATF2 – at the crossroad of nuclear and cytosolic functions

(2012) Eric Lau et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of ATF2 and interaction with NFY induces c-Jun in the gonadotrope

(2012) Lacey L. Lindaman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma

(2012) Kathrin Geiger et al.   MOLECULAR BIOLOGY OF THE CELL

Architecture of the human regulatory network derived from ENCODE data

(2012) Mark B. Gerstein et al.   NATURE

Albendazole causes stage-dependent developmental toxicity and is deactivated by a mammalian metabolization system in a modified zebrafish embryotoxicity test

(2012) Anna Mattsson et al.   REPRODUCTIVE TOXICOLOGY

RNA-Seq analysis in MeV

(2011) E. A. Howe et al.   BIOINFORMATICS

Zebrafish-As an integrative model for twenty-first century toxicity testing

(2011) Nisha S. Sipes et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy

(2011) F. Wei et al.   CURRENT MEDICINAL CHEMISTRY

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

(2011) Chunying Yang et al.   MOLECULAR CELL

WikiPathways: building research communities on biological pathways

(2011) T. Kelder et al.   NUCLEIC ACIDS RESEARCH

Loss of ATF2 Function Leads to Cranial Motoneuron Degeneration during Embryonic Mouse Development

(2011) Julien Ackermann et al.   PLoS One

Albendazole sensitizes cancer cells to ionizing radiation

(2011) Kirtesh Patel et al.   Radiation Oncology

Developmental toxicity of albendazole and its three main metabolites in zebrafish embryos

(2011) Gunnar Carlsson et al.   REPRODUCTIVE TOXICOLOGY

Regulation of cell differentiation by the DNA damage response

(2011) Mara H. Sherman et al.   TRENDS IN CELL BIOLOGY

Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway

(2010) Katsuhiko Mizuno et al.   ARCHIVES OF TOXICOLOGY

In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives

(2010) Kohei Watanabe et al.   BMC NEUROSCIENCE

DNA damage signaling in response to double-strand breaks during mitosis

(2010) Simona Giunta et al.   JOURNAL OF CELL BIOLOGY

Mkp1 Is a c-Jun Target Gene That Antagonizes JNK-Dependent Apoptosis in Sympathetic Neurons

(2010) M. Kristiansen et al.   JOURNAL OF NEUROSCIENCE

Entrez Gene: gene-centered information at NCBI

(2010) D. Maglott et al.   NUCLEIC ACIDS RESEARCH

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

(2009) Lan Shao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small molecule screen for compounds that affect vascular development in the zebrafish retina

(2009) Satish S. Kitambi et al.   MECHANISMS OF DEVELOPMENT

The role of the DNA damage response pathways in brain development and microcephaly: Insight from human disorders

(2008) Mark O’Driscoll et al.   DNA REPAIR

The role of the DNA damage response in neuronal development, organization and maintenance

(2008) Ari Barzilai et al.   DNA REPAIR