Olaparib: A Clinically Applied PARP Inhibitor Protects from Experimental Crohn’s Disease and Maintains Barrier Integrity by Improving Bioenergetics through Rescuing Glycolysis in Colonic Epithelial Cells

Pharmacological inhibition of GLUT1 as a new immunotherapeutic approach after myocardial infarction

(2021) Ziyi Chen et al.   BIOCHEMICAL PHARMACOLOGY

PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis

(2020) Dae-Seok Kim et al.   GENES & DEVELOPMENT

Insights into the functional aspects of poly(ADP‐ribose) polymerase‐1 (PARP‐1) in mitochondrial homeostasis in Dictyostelium discoideum

(2020) Ashlesha Kadam et al.   BIOLOGY OF THE CELL

Thermodynamic efficiency, reversibility, and degree of coupling in energy conservation by the mitochondrial respiratory chain

(2020) Mårten Wikström et al.   Communications Biology

Mitochondrial disorders of the OXPHOS system

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Poly(ADP‑ribose) polymerase‑1 inhibitor ameliorates dextran sulfate sodium‑induced colitis in mice by regulating the balance of Th17/Treg cells and inhibiting the NF‑κB signaling pathway

(2020) Shuai Peng et al.   Experimental and Therapeutic Medicine

Diagnostic and Clinical Significance of Serum Levels of D-Lactate and Diamine Oxidase in Patients with Crohn’s Disease

(2019) Jierui Cai et al.   Gastroenterology Research and Practice

Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease

(2019) Danielle Carson et al.   CELLULAR MICROBIOLOGY

Anti-Inflammatory and Antioxidant Properties of Dehydrated Potato-Derived Bioactive Compounds in Intestinal Cells

(2019) Manuela Giovanna Basilicata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases

(2019) Simonetta Pazzaglia et al.   Cells

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

(2018) Caroline C. Gillis et al.   Cell Host & Microbe

Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis

(2018) Eva Rath et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal barriers protect against disease

(2018) Sandra Citi   SCIENCE

PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome

(2018) Antal Tapodi et al.   BIOCHEMICAL PHARMACOLOGY

Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation

(2017) Sandra Heller et al.   FASEB JOURNAL

NAD metabolism fuels human and mouse intestinal inflammation

(2017) Romana R Gerner et al.   GUT

Diagnostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Crohn’s Disease

(2017) Jue-Rong Feng et al.   Gastroenterology Research and Practice

Application of the Onodera prognostic nutrition index and neutrophil-to-lymphocyte ratio in risk evaluation of postoperative complications in Crohn’s disease

(2017) Wei-Ming Kang et al.   Scientific Reports

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

(2016) L. Oplustil O'Connor et al.   CANCER RESEARCH

The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival

(2016) T. Jubin et al.   CELL PROLIFERATION

Oxygen metabolism and barrier regulation in the intestinal mucosa

(2016) Louise E. Glover et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

High Concentrations of H2O2 Make Aerobic Glycolysis Energetically More Favorable for Cellular Respiration

(2016) Hamid R. Molavian et al.   Frontiers in Physiology

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Gene Polymorphisms That Protect Mice From Colitis

(2013) Florian Bär et al.   GASTROENTEROLOGY

Neutrophil-Lymphocyte Ratio as a Predictor of Disease Severity in Ulcerative Colitis

(2013) Mehmet Celikbilek et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis

(2012) Srikanth Santhanam et al.   INFLAMMATORY BOWEL DISEASES

Intestinal barrier function in health and gastrointestinal disease

(2012) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Glutamine Treatment Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis

(2012) Irene Crespo et al.   PLoS One

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Inflammatory Bowel Disease

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Seroreactivity against glycolytic enzymes in inflammatory bowel disease

(2010) Nathalie Vermeulen et al.   INFLAMMATORY BOWEL DISEASES

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment

(2010) Rudolf Schicho et al.   INFLAMMATORY BOWEL DISEASES

Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohnʼs disease

(2009) Belén Beltrán et al.   INFLAMMATORY BOWEL DISEASES