The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival

Poly (ADP-ribose) polymerase1 regulates growth and multicellularity in D. discoideum

(2016) Tina Jubin et al.   DIFFERENTIATION

Abstract CT325: Combination of the PARP inhibitor veliparib (ABT888) with irinotecan in patients with triple negative breast cancer: Preliminary activity and signature of response

(2015) Patricia M. LoRusso et al.   CANCER RESEARCH

Response ofDictyostelium discoideumto UV-C and involvement of poly (ADP-ribose) polymerase

(2015) H. Mir et al.   CELL PROLIFERATION

Gene activation-associated long noncoding RNAs function in mouse preimplantation development

(2015) N. Hamazaki et al.   DEVELOPMENT

A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation — An NRG Oncology/Gynecologic Oncology Group study

(2015) Robert L. Coleman et al.   GYNECOLOGIC ONCOLOGY

Preliminary activity of veliparib (V) in BRCA2-mutated metastatic castration-resistant prostate cancer (mCRPC).

(2015) Shalu Pahuja et al.   JOURNAL OF CLINICAL ONCOLOGY

Olaparib Monotherapy in Patients With Advanced Cancer and a GermlineBRCA1/2Mutation

(2015) Bella Kaufman et al.   JOURNAL OF CLINICAL ONCOLOGY

Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial

(2015) Amit M Oza et al.   LANCET ONCOLOGY

A phase 1 safety study of veliparib combined with cisplatin and etoposide in extensive stage small cell lung cancer: A trial of the ECOG–ACRIN Cancer Research Group (E2511)

(2015) Taofeek K. Owonikoko et al.   LUNG CANCER

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

(2015) Si Xie et al.   MOLECULAR CELL

PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription

(2015) Honglei Zhao et al.   MOLECULAR CELL

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

(2015) Sebastian Eustermann et al.   MOLECULAR CELL

Poly(ADP-ribose) polymerases as modulators of mitochondrial activity

(2015) Peter Bai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

(2015) Lior Izhar et al.   Cell Reports

Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation

(2015) Narasimharao Nalabothula et al.   PLoS One

Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy

(2014) Edwin Choy et al.   BMC CANCER

Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life

(2014) Dragutin Perina et al.   DNA REPAIR

Safety and Feasibility Update of Olaparib, an Orally Bioavailable PARP Inhibitor, With Concurrent Cetuximab and Radiation Therapy in Heavy Smokers With Stage III-IVB Squamous Cell Carcinoma of the Head/Neck: A Phase 1 Trial

(2014) T.V. Waxweiler et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer

(2014) Maha Hussain et al.   INVESTIGATIONAL NEW DRUGS

Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study

(2014) Joyce F Liu et al.   LANCET ONCOLOGY

Proteases involved during oxidative stress-induced poly(ADP-ribose) polymerase-mediated cell death in Dictyostelium discoideum

(2014) J. Rajawat et al.   MICROBIOLOGY-SGM

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(2014) Domokos Gerö et al.   MOLECULAR MEDICINE

MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation

(2014) Hongshan Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark

(2014) Niraj Lodhi et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of poly(ADP-ribose) polymerase in paraptotic cell death of D. discoideum

(2013) Jyotika Rajawat et al.   APOPTOSIS

Poly(ADP-ribosyl)ation Regulates Insulator Function and Intrachromosomal Interactions in Drosophila

(2013) Chin-Tong Ong et al.   CELL

TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death

(2013) Justyna Sosna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

(2013) Julio Morales et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

DNA-dependent SUMO modification of PARP-1

(2013) Nicola Zilio et al.   DNA REPAIR

PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation

(2013) Amanda O‧Donnell et al.   EMBO REPORTS

A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer

(2013) Joyce F. Liu et al.   EUROPEAN JOURNAL OF CANCER

Correlation between PARP-1 immunoreactivity and cytomorphological features of parthanatos, a specific cellular death in breast cancer cells

(2013) P. Donizy et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

The recognition and removal of cellular poly(ADP-ribose) signals

(2013) Eva Barkauskaite et al.   FEBS Journal

Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription

(2013) Tongde Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling

(2013) Matthias Altmeyer et al.   MOLECULAR CELL

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases

(2013) Florian Rosenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PARP-1 Controls Immunosuppressive Function of Regulatory T Cells by Destabilizing Foxp3

(2013) Pin Zhang et al.   PLoS One

Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair

(2013) M. Robu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of cell death programs in males and females by Poly (ADP-Ribose) Polymerase-1 and 17 β estradiol

(2013) N R Jog et al.   Cell Death & Disease

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology

(2013) Sejal Vyas et al.   Nature Communications

A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas

(2012) S. Kummar et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Targeting PARP in Cancer Treatment

(2012) K. Do et al.   CLINICAL CANCER RESEARCH

ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation

(2012) Süheda Erener et al.   FASEB JOURNAL

Regulation of Poly(ADP-ribose) Polymerase-1-dependent Gene Expression through Promoter-directed Recruitment of a Nuclear NAD+Synthase

(2012) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Death and Autophagy under Oxidative Stress: Roles of Poly(ADP-Ribose) Polymerases and Ca2+

(2012) P. Wyrsch et al.   MOLECULAR AND CELLULAR BIOLOGY

Inheritance of Silent rDNA Chromatin Is Mediated by PARP1 via Noncoding RNA

(2012) Claudio Guetg et al.   MOLECULAR CELL

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

(2012) Claudia A. Doege et al.   NATURE

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

(2012) Britt Adamson et al.   NATURE CELL BIOLOGY

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

(2012) Jonathan Ledermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Dual Roles of PARP-1 Promote Cancer Growth and Progression

(2012) M. J. Schiewer et al.   Cancer Discovery

Differential Role of Poly(ADP-ribose) polymerase in D. discoideum growth and development

(2011) Jyotika Rajawat et al.   BMC DEVELOPMENTAL BIOLOGY

Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase

(2011) F Moroni et al.   BRITISH JOURNAL OF PHARMACOLOGY

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

(2011) Péter Bai et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Novel poly (ADP-ribose) polymerase 1 binding motif in hepatitis B virus core promoter impairs DNA damage repair

(2011) Hui-Ling Ko et al.   HEPATOLOGY

Induced pluripotent stem cells: A new technology to study human diseases

(2011) Alejandra M. Vitale et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study

(2011) Jens Samol et al.   INVESTIGATIONAL NEW DRUGS

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

(2011) C. Anne-Marie Couto et al.   JOURNAL OF CELL BIOLOGY

Phase II, Open-Label, Randomized, Multicenter Study Comparing the Efficacy and Safety of Olaparib, a Poly (ADP-Ribose) Polymerase Inhibitor, and Pegylated Liposomal Doxorubicin in Patients WithBRCA1orBRCA2Mutations and Recurrent Ovarian Cancer

(2011) Stan B. Kaye et al.   JOURNAL OF CLINICAL ONCOLOGY

The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

(2011) Sebastian Eustermann et al.   JOURNAL OF MOLECULAR BIOLOGY

Herpes Simplex Virus Requires Poly(ADP-Ribose) Polymerase Activity for Efficient Replication and Induces Extracellular Signal-Related Kinase-Dependent Phosphorylation and ICP0-Dependent Nuclear Localization of Tankyrase 1

(2011) Z. Li et al.   JOURNAL OF VIROLOGY

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Poly(ADP-Ribose)Polymerase-1 (PARP1) Controls Adipogenic Gene Expression and Adipocyte Function

(2011) Süheda Erener et al.   MOLECULAR ENDOCRINOLOGY

Poly(ADP-ribose) Polymerase-1 Is a Nuclear Epigenetic Regulator of Mitochondrial DNA Repair and Transcription

(2011) A. Lapucci et al.   MOLECULAR PHARMACOLOGY

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

(2011) Dea Slade et al.   NATURE

A Key Role for Poly(ADP-Ribose) Polymerase 3 in Ectodermal Specification and Neural Crest Development

(2011) Michèle Rouleau et al.   PLoS One

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

(2011) A. G. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin

(2011) E. Kotova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells

(2011) Young-Ok Son et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial and Nuclear Cross Talk in Cell Death

(2010) Shaida A. Andrabi et al.   Annals of the New York Academy of Sciences

Evolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes

(2010) Matteo Citarelli et al.   BMC EVOLUTIONARY BIOLOGY

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

(2010) Gad Asher et al.   CELL

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

PARP is involved in replicative aging in Neurospora crassa

(2010) Gregory O. Kothe et al.   FUNGAL GENETICS AND BIOLOGY

The Zn3 Domain of Human Poly(ADP-ribose) Polymerase-1 (PARP-1) Functions in Both DNA-dependent Poly(ADP-ribose) Synthesis Activity and Chromatin Compaction

(2010) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trypanosoma cruziInduces the Reactive Oxygen Species-PARP-1-RelA Pathway for Up-regulation of Cytokine Expression in Cardiomyocytes

(2010) Xueqing Ba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA

(2010) Olga Loseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer

(2010) Bryan T.J. Hennessy et al.   JOURNAL OF CLINICAL ONCOLOGY

Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses inBRCACarrier Ovarian Cancer Correlating With Platinum-Free Interval

(2010) Peter C. Fong et al.   JOURNAL OF CLINICAL ONCOLOGY

PARP1 deficiency exacerbates diet-induced obesity in mice

(2010) Kishor Devalaraja-Narashimha et al.   JOURNAL OF ENDOCRINOLOGY

Increased Foxp3+ Regulatory T Cells in Poly(ADP-Ribose) Polymerase-1 Deficiency

(2010) F. Nasta et al.   JOURNAL OF IMMUNOLOGY

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Overexpression of PaParp encoding the poly(ADP-ribose) polymerase of Podospora anserina affects organismal aging

(2010) Mathis Müller-Ohldach et al.   MECHANISMS OF AGEING AND DEVELOPMENT

PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

Activation of PARP-1 in response to bleomycin depends on the Ku antigen and protein phosphatase 5

(2010) F Dong et al.   ONCOGENE

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage

(2009) Qing Huang et al.   Autophagy

PARP-1 is involved in autophagy induced by DNA damage

(2009) José Antonio Muñoz-Gámez et al.   Autophagy

Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines

(2009) T Zaremba et al.   BRITISH JOURNAL OF CANCER

Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential

(2009) WooKee Min   Frontiers in Bioscience-Landmark

Global Analysis of Transcriptional Regulation by Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase in MCF-7 Human Breast Cancer Cells

(2009) Kristine M. Frizzell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCCTC-binding factor meets poly(ADP-ribose) polymerase-1

(2009) Paola Caiafa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

New functions for an ancient domain

(2009) W Lee Kraus   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

(2009) Matthias Altmeyer et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

(2009) A. J. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes

(2009) Ashok Agarwal et al.   Reproductive Biology and Endocrinology

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

No death without life: vital functions of apoptotic effectors

(2008) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Poly(ADP-ribose) polymerase activity in different pathologies – The link to inflammation and infarction

(2008) Sascha Beneke   EXPERIMENTAL GERONTOLOGY

Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns

(2008) Paola Caiafa et al.   FASEB JOURNAL

Poly(ADP-Ribose) Polymerase-1 Enhances Transcription of the Profibrotic CCN2 Gene

(2008) H. Okada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APLF (C2orf13) Is a Novel Component of Poly(ADP-Ribose) Signaling in Mammalian Cells

(2008) S. L. Rulten et al.   MOLECULAR AND CELLULAR BIOLOGY

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE

Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

(2008) R. Krishnakumar et al.   SCIENCE