Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease

ADP heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori

(2019) Lennart Pfannkuch et al.   FASEB JOURNAL

Intestinal Epithelial Cells and the Microbiome Undergo Swift Reprogramming at the Inception of Colonic Citrobacter rodentium Infection

(2019) Eve G. D. Hopkins et al.   mBio

Citrobacter rodentium–host–microbiota interactions: immunity, bioenergetics and metabolism

(2019) Caroline Mullineaux-Sanders et al.   NATURE REVIEWS MICROBIOLOGY

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

(2018) Caroline C. Gillis et al.   Cell Host & Microbe

Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors

(2018) Laurie Pinaud et al.   TRENDS IN MICROBIOLOGY

Loss of disease tolerance during Citrobacter rodentium infection is associated with impaired epithelial differentiation and hyperactivation of T cell responses

(2018) Eugene Kang et al.   Scientific Reports

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

(2018) Ping Zhou et al.   NATURE

Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

(2018) Grigory Ryzhakov et al.   Nature Communications

ADP‐heptose is a newly identified pathogen‐associated molecular pattern of Shigella flexneri

(2018) Diego García‐Weber et al.   EMBO REPORTS

Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

(2018) Chuansheng Guo et al.   IMMUNITY

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses

(2018) Cedric N. Berger et al.   PLoS Pathogens

Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer

(2017) C Wang et al.   Mucosal Immunology

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study

(2016) Jie Liu et al.   LANCET

Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells

(2016) M A Pallett et al.   Mucosal Immunology

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Citrobacter rodentium mouse model of bacterial infection

(2016) Valerie F Crepin et al.   Nature Protocols

TIFA as a crucial mediator for NLRP3 inflammasome

(2016) Ting-Yang Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reg4+deep crypt secretory cells function as epithelial niche for Lgr5+stem cells in colon

(2016) Nobuo Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration

(2016) C. A. Lopez et al.   SCIENCE

R-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice

(2016) Eugene Kang et al.   PLoS One

Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination

(2015) Nobuhiko Kamada et al.   Cell Host & Microbe

Citrobacter rodentium: infection, inflammation and the microbiota

(2014) James W. Collins et al.   NATURE REVIEWS MICROBIOLOGY

NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription

(2013) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

(2013) Han Xiao et al.   CIRCULATION

TIFA upregulation after hypoxia–reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release

(2013) Ning Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen

(2013) S Nordlander et al.   Mucosal Immunology

Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen

(2013) G X Song-Zhao et al.   Mucosal Immunology

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

R-Spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea

(2013) Olivier Papapietro et al.   Nature Communications

Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation

(2012) Olivier Boulard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Identification and characterization of Cri1, a locus controlling mortality during Citrobacter rodentium infection in mice

(2011) E Diez et al.   GENES AND IMMUNITY

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements

(2011) Alexander R. C. Wong et al.   MOLECULAR MICROBIOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Gene modulation and immunoregulatory roles of Interferonγ

(2009) Banishree Saha et al.   CYTOKINE

Cdcs1 a major colitis susceptibility locus in mice; Subcongenic analysis reveals genetic complexity

(2009) Andre Bleich et al.   INFLAMMATORY BOWEL DISEASES

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Fc  Receptor Regulation of Citrobacter rodentium Infection

(2008) A. Masuda et al.   INFECTION AND IMMUNITY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE