PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis

Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing

(2019) Elena A. Matveeva et al.   Epigenetics & Chromatin

An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

(2019) Ivo A Hendriks et al.   MOLECULAR & CELLULAR PROTEOMICS

Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib

(2019) Kelly E McCann   Future Oncology

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

(2019) Yongjia Duan et al.   CELL RESEARCH

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression

(2019) Matthew E. Grunewald et al.   PLoS Pathogens

Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21

(2019) Dae-Seok Kim et al.   MOLECULAR CELL

Reversible ADP-ribosylation of RNA

(2019) Deeksha Munnur et al.   NUCLEIC ACIDS RESEARCH

CpG dinucleotides inhibit HIV-1 replication through zinc finger antiviral protein (ZAP)-dependent and -independent mechanisms

(2019) Mattia Ficarelli et al.   JOURNAL OF VIROLOGY

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions

(2019) Johannes Schwerk et al.   NATURE IMMUNOLOGY

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences

(2019) Jennifer L. Meagher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Eukaryotic translation elongation factor 2 (eEF2) catalyzes reverse translocation of the eukaryotic ribosome

(2018) Denis Susorov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the biogenesis, function, and regulation of ADP-ribosylation

(2018) Michael S Cohen et al.   Nature Chemical Biology

Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation

(2018) Gabriella Zarkovic et al.   NUCLEIC ACIDS RESEARCH

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic regulation of transcription through compartmentalized NAD+biosynthesis

(2018) Keun Woo Ryu et al.   SCIENCE

Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis

(2018) Anthony R. Fehr et al.   TRENDS IN MICROBIOLOGY

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription

(2018) Mareike Bütepage et al.   Scientific Reports

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

(2018) David C. Schöndorf et al.   Cell Reports

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

(2018) Leeanne McGurk et al.   MOLECULAR CELL

NAD+-dependent synthesis of a 5′-phospho-ADP-ribosylated RNA/DNA cap by RNA 2′-phosphotransferase Tpt1

(2018) Annum Munir et al.   NUCLEIC ACIDS RESEARCH

PARP12 (ARTD12) suppresses hepatocellular carcinoma metastasis through interacting with FHL2 and regulating its stability

(2018) Changjuan Shao et al.   Cell Death & Disease

Eurokaryotic Ribosome Assembly

(2018) Jochen Baßler et al.   Annual Review of Biochemistry

ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

(2018) Rachy Abraham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Reversible mono-ADP-ribosylation of DNA breaks

(2017) Deeksha Munnur et al.   FEBS Journal

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

PARP inhibitors: Clinical utility and possibilities of overcoming resistance

(2017) Benjamin G. Bitler et al.   GYNECOLOGIC ONCOLOGY

Genetic mutations in RNA-binding proteins and their roles in ALS

(2017) Katannya Kapeli et al.   HUMAN GENETICS

PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity

(2017) Xin Luo et al.   MOLECULAR CELL

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

(2017) Mark Robson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response

(2017) Tatsuya Kozaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

(2017) Robert Lyle McPherson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation

(2017) Amit Bhardwaj et al.   Nature Communications

PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR

(2017) Yueshuang Ke et al.   Nature Communications

A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer

(2017) Yuanli Zhen et al.   Cell Reports

Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses

(2017) Andrew E. Shaw et al.   PLOS BIOLOGY

Transcriptome-wide identification of the RNA-binding landscape of the chromatin-associated protein PARP1 reveals functions in RNA biogenesis

(2017) Manana Melikishvili et al.   Cell Discovery

TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors

(2016) C. Bindesboll et al.   BIOCHEMICAL JOURNAL

Actin ADP-ribosylation at Threonine148 by Photorhabdus luminescens toxin TccC3 induces aggregation of intracellular F-actin

(2016) Alexander E. Lang et al.   CELLULAR MICROBIOLOGY

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Viral Macro Domains Reverse Protein ADP-Ribosylation

(2016) Changqing Li et al.   JOURNAL OF VIROLOGY

The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA

(2016) Gytis Jankevicius et al.   MOLECULAR CELL

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

(2016) Jiazhang Qiu et al.   NATURE

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

(2016) Mansoor R. Mirza et al.   NEW ENGLAND JOURNAL OF MEDICINE

Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragmentsin vitro

(2016) Ibtissam Talhaoui et al.   NUCLEIC ACIDS RESEARCH

Biosensor reveals multiple sources for mitochondrial NAD+

(2016) X. A. Cambronne et al.   SCIENCE

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

(2016) B. A. Gibson et al.   SCIENCE

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

(2016) Hiroshi Iwata et al.   Nature Communications

In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation

(2016) Angelica Aguilera-Gomez et al.   eLife

Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition

(2016) Jianying Zeng et al.   NEURAL PLASTICITY

Involvement of PARP1 in the regulation of alternative splicing

(2016) Elena Matveeva et al.   Cell Discovery

New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases

(2015) Keun Woo Ryu et al.   CHEMICAL REVIEWS

Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality

(2015) Shaimaa Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Regulation by Poly(ADP-Ribose) Polymerases

(2015) Florian J. Bock et al.   MOLECULAR CELL

SnapShot: ADP-Ribosylation Signaling

(2015) Michael O. Hottiger   MOLECULAR CELL

The Promise of Proteomics for the Study of ADP-Ribosylation

(2015) Casey M. Daniels et al.   MOLECULAR CELL

Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor

(2015) Sebastian Stahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

(2014) M. B. Iqbal et al.   BLOOD

PARP12, an Interferon-stimulated Gene Involved in the Control of Protein Translation and Inflammation

(2014) Iain Welsby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poly(ADP-ribose): An organizer of cellular architecture

(2014) Anthony K.L. Leung   JOURNAL OF CELL BIOLOGY

Engineering the Substrate Specificity of ADP-Ribosyltransferases for Identifying Direct Protein Targets

(2014) Ian Carter-O’Connell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis

(2014) Anthony R. Fehr et al.   JOURNAL OF VIROLOGY

Novel bacterial ADP-ribosylating toxins: structure and function

(2014) Nathan C. Simon et al.   NATURE REVIEWS MICROBIOLOGY

ARTD2 activity is stimulated by RNA

(2014) Karolin Léger et al.   NUCLEIC ACIDS RESEARCH

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells

(2014) Stephen J. Roper et al.   NUCLEIC ACIDS RESEARCH

Family-wide analysis of poly(ADP-ribose) polymerase activity

(2014) Sejal Vyas et al.   Nature Communications

PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript

(2014) Tanya Todorova et al.   Nature Communications

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

(2013) Julio Morales et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins

(2013) Alejandro Ocampo et al.   HUMAN MOLECULAR GENETICS

Poly(ADP-ribose) polymerase 1 regulates nuclear reprogramming and promotes iPSC generation without c-Myc

(2013) Shih-Hwa Chiou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-Stimulated Poly(ADP-Ribose) Polymerases Are Potent Inhibitors of Cellular Translation and Virus Replication

(2013) S. Atasheva et al.   JOURNAL OF VIROLOGY

Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

(2013) Stephanie Jungmichel et al.   MOLECULAR CELL

Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome

(2013) Yajie Zhang et al.   NATURE METHODS

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1

(2013) Anne S. Calkins et al.   NUCLEIC ACIDS RESEARCH

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology

(2013) Sejal Vyas et al.   Nature Communications

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Regulation of Poly(ADP-ribose) Polymerase-1-dependent Gene Expression through Promoter-directed Recruitment of a Nuclear NAD+Synthase

(2012) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation

(2012) Lisa Kashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inheritance of Silent rDNA Chromatin Is Mediated by PARP1 via Noncoding RNA

(2012) Claudio Guetg et al.   MOLECULAR CELL

PARP1 Represses PAP and Inhibits Polyadenylation during Heat Shock

(2012) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

(2012) Miri Jwa et al.   NATURE CELL BIOLOGY

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress

(2012) Jean-Philippe Gagné et al.   NUCLEIC ACIDS RESEARCH

PARP16/ARTD15 Is a Novel Endoplasmic-Reticulum-Associated Mono-ADP-Ribosyltransferase That Interacts with, and Modifies Karyopherin-ß1

(2012) Simone Di Paola et al.   PLoS One

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

(2012) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential GC Content between Exons and Introns Establishes Distinct Strategies of Splice-Site Recognition

(2012) Maayan Amit et al.   Cell Reports

Poly(ADP-Ribose) Polymerase 1 (PARP-1) Regulates Ribosomal Biogenesis in Drosophila Nucleoli

(2012) Ernest K. Boamah et al.   PLoS Genetics

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy

(2011) Pawel Domagala et al.   BREAST CANCER RESEARCH AND TREATMENT

NMNAT Expression and its Relation to NAD Metabolism

(2011) H. N. Jayaram et al.   CURRENT MEDICINAL CHEMISTRY

Ubiquitination of mRNA cycling sequence binding protein fromLeishmania donovani(LdCSBP) modulates the RNA endonuclease activity of its Smr domain

(2011) Dipankar Bhandari et al.   FEBS LETTERS

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

(2011) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing

(2010) Schraga Schwartz et al.   EMBO JOURNAL

Viral Induction of the Zinc Finger Antiviral Protein Is IRF3-dependent but NF-κB-independent

(2010) Nan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

(2010) Maxim Isabelle et al.   Proteome Science

Photorhabdus luminescens Toxins ADP-Ribosylate Actin and RhoA to Force Actin Clustering

(2010) A. E. Lang et al.   SCIENCE

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

The NMN/NaMN adenylyltransferase (NMNAT) protein family

(2009) Corinna Lau   Frontiers in Bioscience-Landmark

Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation

(2009) D. Farrar et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex

(2009) Yongsheng Shi et al.   MOLECULAR CELL

Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing

(2009) Yingbiao Ji et al.   NUCLEIC ACIDS RESEARCH

Molecular Mechanisms of the Cytotoxicity of ADP-Ribosylating Toxins

(2008) Qing Deng et al.   Annual Review of Microbiology

3′ end mRNA processing: molecular mechanisms and implications for health and disease

(2008) Sven Danckwardt et al.   EMBO JOURNAL

Poly(ADP-ribose) Binds to the Splicing Factor ASF/SF2 and Regulates Its Phosphorylation by DNA Topoisomerase I

(2008) Maria Malanga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Transcription Factor NFAT by ADP-Ribosylation

(2008) O. A. Olabisi et al.   MOLECULAR AND CELLULAR BIOLOGY