Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism

Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD

(2021) Jennifer R. Mepham et al.   BEHAVIOURAL BRAIN RESEARCH

Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

(2020) Dexiang Liu et al.   Frontiers in Pharmacology

Autism Spectrum Disorder: Signaling Pathways and Prospective Therapeutic Targets

(2020) Juliana Baranova et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus

(2020) Quentin Delmotte et al.   Frontiers in Cellular Neuroscience

Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD

(2019) Jennifer R. Mepham et al.   NEUROTOXICITY RESEARCH

Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder

(2019) Soaleha Shams et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice

(2019) Suping Qin et al.   BEHAVIOURAL BRAIN RESEARCH

Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN/AKT Pathway in Autism Spectrum Disorder

(2019) Latifa S. Abdelli et al.   Scientific Reports

Emerging neuroprotective effect of metformin in Parkinson’s disease: A molecular crosstalk

(2019) Yam Nath Paudel et al.   PHARMACOLOGICAL RESEARCH

Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats

(2019) Melissa M. Meeking et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Pathophysiological and neurobehavioral characteristics of a propionic acid-mediated autism-like rat model

(2018) Jeonghyun Choi et al.   PLoS One

Activation of Sonic hedgehog signal by Purmorphamine, in a mouse model of Parkinson's disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway

(2017) Shuai Shao et al.   Molecular Medicine Reports

Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders

(2017) Sidharth Mehan et al.   Neural Regeneration Research

Targeting sonic hedgehog signaling in neurological disorders

(2017) Sita Sharan Patel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats

(2017) Quan Hu et al.   Frontiers in Cellular Neuroscience

Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function

(2017) Anna Drannik et al.   PLoS One

Therapeutic potency of bee pollen against biochemical autistic features induced through acute and sub-acute neurotoxicity of orally administered propionic acid

(2016) Huda S. Al-Salem et al.   BMC Complementary and Alternative Medicine

Autism in patients with propionic acidemia

(2016) Peter Witters et al.   MOLECULAR GENETICS AND METABOLISM

Sonic Hedgehog Signaling and Hippocampal Neuroplasticity

(2016) Pamela J. Yao et al.   TRENDS IN NEUROSCIENCES

Development of MOF-Derived Carbon-Based Nanomaterials for Efficient Catalysis

(2016) Kui Shen et al.   ACS Catalysis

The effect of purmorphamine on differentiation of endometrial stem cells into osteoblast-like cells on collagen/hydroxyapatite scaffolds

(2016) Naghmeh Bahrami et al.   Artificial Cells Nanomedicine and Biotechnology

Abnormalities of Inter- and Intra-Hemispheric Functional Connectivity in Autism Spectrum Disorders: A Study Using the Autism Brain Imaging Data Exchange Database

(2016) Jung Min Lee et al.   Frontiers in Neuroscience

Genetic research in autism spectrum disorders

(2015) Elise B. Robinson et al.   CURRENT OPINION IN PEDIATRICS

The neuroprotective effect of berberine in mercury-induced neurotoxicity in rats

(2015) Ahmed E. Abdel Moneim   METABOLIC BRAIN DISEASE

Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism

(2015) Sumit Jamwal et al.   NEUROTOXICITY RESEARCH

Apitoxin protects rat pups brain from propionic acid-induced oxidative stress: The expression pattern of Bcl-2 and Caspase-3 apoptotic genes

(2015) Samah R. Khalil et al.   NEUROTOXICOLOGY

A Novel Rat Model of Blast-Induced Traumatic Brain Injury Simulating Different Damage Degree: Implications for Morphological, Neurological, and Biomarker Changes

(2015) Mengdong Liu et al.   Frontiers in Cellular Neuroscience

Preclinical appraisal of terbutaline analogues in precipitation of autism spectrum disorder

(2015) Neha Sharma et al.   RSC Advances

Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups

(2014) Hanan A Alfawaz et al.   BMC Complementary and Alternative Medicine

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

(2014) Bistra B. Nankova et al.   PLoS One

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

(2014) Yue Wang et al.   PLoS One

A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury

(2014) O V Chechneva et al.   Cell Death & Disease

Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington’s disease

(2012) Gehan El-Akabawy et al.   BMC NEUROSCIENCE

Glutathione-Related Factors and Oxidative Stress in Autism, A Review

(2012) A. Ghanizadeh et al.   CURRENT MEDICINAL CHEMISTRY

Etiology of autistic features: the persisting neurotoxic effects of propionic acid

(2012) Afaf K El-Ansary et al.   Journal of Neuroinflammation

The protective effect of sonic hedgehog is mediated by the propidium iodide 3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under oxidative stress

(2012) Y.-P. Xia et al.   NEUROSCIENCE

Amelioration of experimental autoimmune myasthenia gravis rats by blood purification treatment using 4-mercaptoethylpyridine-based adsorbent

(2011) Jun Ren et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells

(2011) F.S. Oliveira et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sonic Hedgehog is Cytoprotective against Oxidative Challenge in a Cellular Model of Amyotrophic Lateral Sclerosis

(2011) Randy Peterson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Repeated Mild Lateral Fluid Percussion Brain Injury in the Rat Causes Cumulative Long-Term Behavioral Impairments, Neuroinflammation, and Cortical Loss in an Animal Model of Repeated Concussion

(2011) Sandy R. Shultz et al.   JOURNAL OF NEUROTRAUMA

On the protective effect of omega-3 against propionic acid-induced neurotoxicity in rat pups

(2011) Afaf K El-Ansary et al.   Lipids in Health and Disease

Relationship Between Sonic Hedgehog Protein, Brain-Derived Neurotrophic Factor and Oxidative Stress in Autism Spectrum Disorders

(2011) Laila Y. Al-Ayadhi   NEUROCHEMICAL RESEARCH

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

(2010) Derrick F. MacFabe et al.   BEHAVIOURAL BRAIN RESEARCH

Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor

(2009) Rahul Deshmukh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long–Evans rat: Further development of a rodent model of autism

(2008) Sandy R. Shultz et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES

5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletion

(2007) Melissa Lamar et al.   NEUROBIOLOGY OF AGING