Pharmacological relevance of CDK inhibitors in Alzheimer's disease

Cellular Senescence in Brain Aging

(2021) Ewa Sikora et al.   Frontiers in Aging Neuroscience

Analysis of E1A domains involved in the enhancement of CDK2 activity

(2021) Yasunori Akaike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review

(2021) Paweł Łukasik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

“Amyloid‐beta accumulation cycle” as a prevention and/or therapy target for Alzheimer's disease

(2020) Chinthalapally V. Rao et al.   AGING CELL

Context-Dependent Functions of E2F1: Cell Cycle, Cell Death, and DNA Damage Repair in Cortical Neurons

(2020) Yang Zhang et al.   MOLECULAR NEUROBIOLOGY

In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs

(2020) Zarko Gagic et al.   Frontiers in Chemistry

Exposure to 3-Nitropropionic Acid Mitochondrial Toxin Induces Tau Pathology in Tangle-Mouse Model and in Wild Type-Mice

(2020) Inbal Lahiani-Cohen et al.   Frontiers in Cell and Developmental Biology

α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2

(2020) Bingxu Huang et al.   Frontiers in Pharmacology

Aberrant activation of neuronal cell cycle caused by dysregulation of ubiquitin ligase Itch results in neurodegeneration

(2020) Monika Chauhan et al.   Cell Death & Disease

Integrating Old and New Paradigms of G1/S Control

(2020) Seth M. Rubin et al.   MOLECULAR CELL

Inhibitory potency of 4- substituted sampangine derivatives toward Cu2+ mediated aggregation of amyloid β-peptide, oxidative stress, and inflammation in Alzheimer's disease

(2020) Chunling Su et al.   NEUROCHEMISTRY INTERNATIONAL

Cytosine arabinoside induces phosphorylation of histone H2AX in hippocampal neurons via a noncanonical pathway

(2020) Saki Nakayama et al.   NEUROCHEMISTRY INTERNATIONAL

Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together

(2019) Shohreh Majd et al.   Frontiers in Neuroscience

Virtual screening, pharmacokinetics, molecular dynamics and binding free energy analysis for small natural molecules against cyclin-dependent kinase 5 for Alzheimer’s disease

(2019) Rohit Shukla et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The Therapeutic Potential of Apigenin

(2019) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Crosstalk between Oxidative Stress and Tauopathy

(2019) Md. Mamunul Haque et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

(2019) Gábor M. Mórotz et al.   Acta Neuropathologica Communications

Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262

(2019) Taro Saito et al.   HUMAN MOLECULAR GENETICS

Nerve growth factor promotes the proliferation of Müller cells co-cultured with internal limiting membrane by regulating cell cycle via Trk-A/PI3K/Akt pathway

(2019) Luyi Zhang et al.   BMC Ophthalmology

Mechanistic insights into the phosphoryl transfer reaction in cyclin-dependent kinase 2: A QM/MM study

(2019) Rodrigo Recabarren et al.   PLoS One

CDK5-dependent BAG3 degradation modulates synaptic protein turnover

(2019) Jiechao Zhou et al.   BIOLOGICAL PSYCHIATRY

CDK5 Participates in Amyloid-β Production by Regulating PPARγ Phosphorylation in Primary Rat Hippocampal Neurons

(2019) Qiankun Quan et al.   JOURNAL OF ALZHEIMERS DISEASE

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

(2019) Hei-Man Chow et al.   NATURE NEUROSCIENCE

Role of Cdk5 in Amyloid-beta Pathology of Alzheimer’s Disease

(2019) Tao-Tao Lu et al.   Current Alzheimer Research

N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease

(2018) Erin J. Kodis et al.   Alzheimers & Dementia

SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation

(2018) Tao Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

(2018) Andre F Batista et al.   JOURNAL OF PATHOLOGY

Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer’s Disease Pathogenesis

(2018) Kumar Nikhil et al.   MOLECULAR NEUROBIOLOGY

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

The antipsychotic drug quetiapine stimulates oligodendrocyte differentiation by modulating the cell cycle

(2018) Guiyun Mi et al.   NEUROCHEMISTRY INTERNATIONAL

Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis

(2018) George S. Bloom et al.   NEUROPHARMACOLOGY

CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway

(2018) Ning Xiao et al.   TOXICOLOGY LETTERS

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression

(2018) Kai Zhuang et al.   Cell Reports

Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons

(2018) E. Barrio-Alonso et al.   Scientific Reports

CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease

(2018) Fang Huang et al.   Alzheimers & Dementia

A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers

(2018) Andrés Norambuena et al.   EMBO JOURNAL

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

(2018) Chin Wai Hui et al.   Journal of Neuroinflammation

NRF2-regulated cell cycle arrest at early stage of oxidative stress response mechanism

(2018) Margita Márton et al.   PLoS One

CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors

(2018) Francesco Schettini et al.   Frontiers in Oncology

Amyloid-ß promotes neurotoxicity by Cdk5-induced p53 stabilization

(2018) Rebeca Lapresa et al.   NEUROPHARMACOLOGY

The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts

(2017) Renier Vélez-Cruz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

(2017) Jinsoo Seo et al.   JOURNAL OF NEUROSCIENCE

Effects of I 2 -imidazoline receptor (IR) alkylating BU99006 in the mouse brain: Upregulation of nischarin/I 1 -IR and μ-opioid receptor proteins and modulation of associated signalling pathways

(2017) Benjamin Keller et al.   NEUROCHEMISTRY INTERNATIONAL

Oxidative stress with tau hyperphosphorylation in memory impaired 1,2-diacetylbenzene-treated mice

(2017) Sin-Woo Kang et al.   TOXICOLOGY LETTERS

Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling

(2017) Vesna Lazarevic et al.   Frontiers in Molecular Neuroscience

Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death

(2017) Ki Hoon Lee et al.   Frontiers in Molecular Neuroscience

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane

(2016) Mark P.A. Luna-Vargas et al.   FEBS Journal

Safflower yellow ameliorates cognition deficits and reduces tau phosphorylation in APP/PS1 transgenic mice

(2016) Ying-ying Ruan et al.   METABOLIC BRAIN DISEASE

Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategies

(2016) Swastika Sur et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Disruption of neuronal nitric oxide synthase dimerization contributes to the development of Alzheimer’s disease: Involvement of cyclin-dependent kinase 5-mediated phosphorylation of neuronal nitric oxide synthase at Ser 293

(2016) Kyoung Ja Kwon et al.   NEUROCHEMISTRY INTERNATIONAL

The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß 1-42 oligomers in mice

(2016) Gian Marco Leggio et al.   PHARMACOLOGICAL RESEARCH

Spatial colocalization and functional link of purinosomes with mitochondria

(2016) J. B. French et al.   SCIENCE

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Physiological and Pharmacological Control of BAK, BAX, and Beyond

(2016) Mark P.A. Luna-Vargas et al.   TRENDS IN CELL BIOLOGY

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

(2016) David J. Bonda et al.   Aging-US

Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer’s disease

(2015) Lucie A. G. van Leeuwen et al.   ACTA NEUROPATHOLOGICA

Neuronal cell cycle: the neuron itself and its circumstances

(2015) José M Frade et al.   CELL CYCLE

PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling

(2015) Camilla Olaisen et al.   CELLULAR SIGNALLING

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

(2015) Zhenzhen Liu et al.   Oxidative Medicine and Cellular Longevity

Resveratrol: A Focus on Several Neurodegenerative Diseases

(2015) Ester Tellone et al.   Oxidative Medicine and Cellular Longevity

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

Signaling pathway cross talk in Alzheimer’s disease

(2014) Juan A Godoy et al.   Cell Communication and Signaling

Insulin Regulates Brain Function, but How Does It Get There?

(2014) S. M. Gray et al.   DIABETES

Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors

(2014) R. S. K. Vijayan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclin-Dependent Kinase Inhibitors as Marketed Anticancer Drugs: Where Are We Now? A Short Survey

(2014) Gaëlle Mariaule et al.   MOLECULES

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach

(2014) John F. Castro-Alvarez et al.   Frontiers in Aging Neuroscience

Physiological and pathological phosphorylation of tau by Cdk5

(2014) Taeko Kimura et al.   Frontiers in Molecular Neuroscience

Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment

(2013) Michael Hallek   AMERICAN JOURNAL OF HEMATOLOGY

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Ins and Outs of Kinase DFG Motifs

(2013) Daniel K. Treiber et al.   CHEMISTRY & BIOLOGY

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

(2013) Kiran Bhaskar et al.   NEUROBIOLOGY OF DISEASE

Signaling Pathways that Control Cell Proliferation

(2013) R. J. Duronio et al.   Cold Spring Harbor Perspectives in Biology

The influence of reactive oxygen species on cell cycle progression in mammalian cells

(2012) Eline Hendrike Verbon et al.   GENE

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3)

(2012) Anders Poulsen et al.   JOURNAL OF MOLECULAR MODELING

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis

(2012) Vincenzo D’Angiolella et al.   TRENDS IN CELL BIOLOGY

A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors

(2011) D. Mahadevan et al.   ANNALS OF ONCOLOGY

Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

(2011) Kuei-Hua Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Cdk5: Multitasking between physiological and pathological conditions

(2011) Joao P. Lopes et al.   PROGRESS IN NEUROBIOLOGY

Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors

(2011) Natalia G. Starostina et al.   TRENDS IN CELL BIOLOGY

Simvastatin overcomes the resistance to serum withdrawal-induced apoptosis of lymphocytes from Alzheimer’s disease patients

(2010) Fernando Bartolomé et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cdk5 Suppresses the Neuronal Cell Cycle by Disrupting the E2F1-DP1 Complex

(2010) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

(2010) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

AT7519, a Cyclin-Dependent Kinase Inhibitor, Exerts Its Effects by Transcriptional Inhibition in Leukemia Cell Lines and Patient Samples

(2010) Matthew S. Squires et al.   MOLECULAR CANCER THERAPEUTICS

Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor

(2010) David Parry et al.   MOLECULAR CANCER THERAPEUTICS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models

(2010) Bénédicte Menn et al.   PLoS One

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5

(2009) Joao P. Lopes et al.   AGING CELL

DNA polymerase-β is required for 1-methyl-4-phenylpyridinium-induced apoptotic death in neurons

(2009) Zhentao Zhang et al.   APOPTOSIS

Synthesis and kinase inhibitory activity of novel substituted indigoids

(2009) Anne Beauchard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins

(2009) Rufine Akue-Gedu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors

(2009) Matthew R. Kaller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease

(2009) Christopher J. Helal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

(2009) Kiyotsugu Yoshida et al.   CANCER SCIENCE

Fine Tuning the Cell Cycle: Activation of the Cdk1 Inhibitory Phosphorylation Pathway during Mitotic Exit

(2009) Tamara A. Potapova et al.   MOLECULAR BIOLOGY OF THE CELL

Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases

(2009) Da-Zhi Liu et al.   NEUROBIOLOGY OF DISEASE

COL25A1 triggers and promotes Alzheimer’s disease-like pathology in vivo

(2009) Ying Tong et al.   NEUROGENETICS

Neural cell cycle dysregulation and central nervous system diseases

(2009) Wei Wang et al.   PROGRESS IN NEUROBIOLOGY

Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy

(2009) Zakir Ullah et al.   Cell Division

Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents

(2008) Ulrich Jacquemard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Different fibrillar Aβ 1–42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle

(2008) Shohreh Majd et al.   BRAIN RESEARCH

Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1

(2008) Nassima Oumata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification ofN-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design†

(2008) Paul G. Wyatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes

(2008) Akiko Asada et al.   JOURNAL OF NEUROCHEMISTRY

Premature centromere division of the X chromosome in neurons in Alzheimer’s disease

(2008) Biljana Spremo-Potparević et al.   JOURNAL OF NEUROCHEMISTRY

DNA Damage and Repair

(2008) Lee J. Martin   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A  Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease

(2008) N. H. Varvel et al.   JOURNAL OF NEUROSCIENCE

Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease

(2008) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

(2008) K. Bettayeb et al.   MOLECULAR CANCER THERAPEUTICS

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

(2008) W. S. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Neuronal binucleation in Alzheimer disease hippocampus

(2007) X. Zhu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY