CDK5 Participates in Amyloid-β Production by Regulating PPARγ Phosphorylation in Primary Rat Hippocampal Neurons

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

The role of Cdk5-mediated Drp1 phosphorylation in Aβ1-42 induced mitochondrial fission and neuronal apoptosis

(2018) Miao-Yu Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies

(2018) Marcelle Silva-Abreu et al.   International Journal of Nanomedicine

Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease

(2018) James L. Searcy et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-β 1-42

(2017) Devkee M. Vadukul et al.   FEBS LETTERS

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis

(2017) Khalil Saadipour et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2017) Abhishek Kumar Singh et al.   NEUROTOXICITY RESEARCH

Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway

(2017) Wei Hong Toh et al.   TRAFFIC

Pioglitazone prevents tau oligomerization

(2016) Tadanori Hamano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses

(2016) W. Li et al.   JOURNAL OF NEUROSCIENCE

Rosiglitazone activation of PPARγ-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta–induced mitochondrial dysfunction and oxidative stress

(2016) Ming-Chang Chiang et al.   NEUROBIOLOGY OF AGING

Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis

(2016) Ya-Li Zheng et al.   PLoS One

p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing

(2015) Rafael Andres Posada-Duque et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of Connexin 43 by Cdk5 Modulates Neuronal Migration During Embryonic Brain Development

(2015) Guang-Jian Qi et al.   MOLECULAR NEUROBIOLOGY

Tripchlorolide Attenuates β-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells

(2015) Nan Lin et al.   MOLECULAR NEUROBIOLOGY

The Role of Cdk5 in Alzheimer’s Disease

(2015) Shu-Lei Liu et al.   MOLECULAR NEUROBIOLOGY

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

(2015) Katherine R Sadleir et al.   Molecular Neurodegeneration

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer’s Disease

(2015) Eun-Jeong Yang et al.   PLoS One

Cdk5/p35 is required for motor coordination and cerebellar plasticity

(2014) Xiaojuan He et al.   JOURNAL OF NEUROCHEMISTRY

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth

(2014) Fanny Duhr et al.   Nature Chemical Biology

Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2014) Katherine R. Sadleir et al.   PLoS One

Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex

(2014) Tao Ye et al.   Nature Communications

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models

(2013) Anita Stargardt et al.   AGING CELL

Axin Directs the Amplification and Differentiation of Intermediate Progenitors in the Developing Cerebral Cortex

(2013) Wei-Qun Fang et al.   NEURON

Early Postnatal In Vivo Gliogenesis From Nestin-Lineage Progenitors Requires Cdk5

(2013) David Petrik et al.   PLoS One

Cdk5/p35 phosphorylates lemur tyrosine kinase-2 to regulate protein phosphatase-1C phosphorylation and activity

(2012) Catherine Manser et al.   JOURNAL OF NEUROCHEMISTRY

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Cyclin-dependent kinase 5 is required for normal cerebellar development

(2012) A. Kumazawa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Wnt signaling activation reduces neuropathological markers in a mouse model of Alzheimer's disease

(2010) E M Toledo et al.   MOLECULAR PSYCHIATRY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

PPARγ transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons

(2009) Jing Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Cdk5 Activity in Neuronal Degeneration and Regeneration

(2009) Jyotshnabala Kanungo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY