Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

A Natural Benzofuran from the Patagonic Aleurodiscus vitellinus Fungus has Potent Neuroprotective Properties on a Cellular Model of Amyloid-β Peptide Toxicity

(2018) Mariela González-Ramírez et al.   JOURNAL OF ALZHEIMERS DISEASE

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy

(2018) Asha Hiremathad et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission

(2018) Jan Korábečný et al.   NEUROSCIENCE

Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease

(2018) Ireen Denya et al.   MedChemComm

Activation of the α-Secretase Processing of AβPP as a Therapeutic Approach in Alzheimer's Disease

(2018) Bruno Vincent et al.   JOURNAL OF ALZHEIMERS DISEASE

Latrepirdine (Dimebon™) Enhances Autophagy and Reduces Intracellular GFP-Aβ42 Levels in Yeast

(2018) Prashant R. Bharadwaj et al.   JOURNAL OF ALZHEIMERS DISEASE

Tubastatin A/ACY-1215 Improves Cognition in Alzheimer's Disease Transgenic Mice

(2018) Ling Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Novel 2-pheynlbenzofuran derivatives as selective butyrylcholinesterase inhibitors for Alzheimer’s disease

(2018) Amit Kumar et al.   Scientific Reports

Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view

(2017) Navriti Chadha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity

(2017) Modesto de Candia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances of pyrrolopyridines derivatives: a patent and literature review

(2017) Mohammed I. El-Gamal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Design, synthesis, molecular modeling and anticholinesterase activity of benzylidene-benzofuran-3-ones containing cyclic amine side chain

(2017) Farzad Mehrabi et al.   Future Medicinal Chemistry

Scrutiny of the mechanism of small molecule inhibitor preventing conformational transition of amyloid-β42 monomer: insights from molecular dynamics simulations

(2017) Suniba Shuaib et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer's Aβ peptide

(2017) Maria Gregori et al.   Nanomedicine-Nanotechnology Biology and Medicine

Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease

(2017) Deepti Goyal et al.   ACS Combinatorial Science

Two decades of new drug discovery and development for Alzheimer's disease

(2017) Zhidong Liu et al.   RSC Advances

Citalopram amplifies the influence of living conditions on mood in depressed patients enrolled in the STAR*D study

(2017) F Chiarotti et al.   Translational Psychiatry

Insights into the Inhibitory Mechanism of Dicyanovinyl-Substituted J147 Derivative against Aβ42Aggregation and Protofibril Destabilization: A Molecular Dynamics Simulation Study

(2017) Suniba Shuaib et al.   ChemistrySelect

Inhibition of PHF-like Tau Hyperphosphorylation in SH-SY5Y Cells and Rat Brain Slices by K252a

(2017) Gabriele Hübinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity

(2016) Huiyuan Li et al.   ACS Chemical Neuroscience

Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage

(2016) Hande Gurer-Orhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation

(2016) Heiko Kroth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling

(2016) Giovanna L. Delogu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease

(2016) Federica Prati et al.   ChemMedChem

The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

(2016) Kuo-Hsuan Chang et al.   CNS Neuroscience & Therapeutics

Drug Development of Small-Molecule Inhibitors of AD-Relevant Kinases as Novel Perspective Multitargeted Approach

(2016) V. Tell et al.   Current Alzheimer Research

Amyloid Beta (Aβ) Peptide and Factors that Play Important Roles in Alzheimer’s Disease

(2016) Elaheh Jamasbi et al.   CURRENT MEDICINAL CHEMISTRY

Adamantane – A Lead Structure for Drugs in Clinical Practice

(2016) Katarina Spilovska et al.   CURRENT MEDICINAL CHEMISTRY

AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease

(2016) Yu Wang et al.   Current Neuropharmacology

Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease

(2016) Annamaria Martorana et al.   CURRENT PHARMACEUTICAL DESIGN

Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry

(2016) Tarek Mohamed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT 6 receptor antagonists. Design, synthesis and biological evaluation

(2016) Anna Więckowska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?

(2016) Matthew G. Bursavich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antiacetylcholinesterase Activity Evaluation of New 2-aryl Benzofuran Derivatives

(2016) Behjat Pouramiri et al.   Letters in Drug Design & Discovery

The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

(2016) Kuo-Hsuan Chang et al.   NEUROPHARMACOLOGY

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

(2016) Jean-François Blain et al.   Alzheimers Research & Therapy

Genomics of Alzheimer Disease

(2016) Roger N. Rosenberg et al.   JAMA Neurology

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

(2016) Mercedes Unzeta et al.   Frontiers in Neuroscience

Design of LVFFARK and LVFFARK-Functionalized Nanoparticles for Inhibiting Amyloid β-Protein Fibrillation and Cytotoxicity

(2015) Neng Xiong et al.   ACS Applied Materials & Interfaces

Computational Studies of Protein Aggregation: Methods and Applications

(2015) Alex Morriss-Andrews et al.   Annual Review of Physical Chemistry

β-Sheet interfering molecules acting against β-amyloid aggregation and fibrillogenesis

(2015) Antonio Francioso et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity

(2015) Mariyana Atanasova et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

(2015) Ondrej Benek et al.   ChemMedChem

Socio-economic Aspects of Alzheimer's Disease

(2015) Petra Maresova et al.   Current Alzheimer Research

Inhibition of protein aggregation and amyloid formation by small molecules

(2015) Andrew J Doig et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease

(2015) Xiao-Ting Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioactive Benzofuran derivatives: A review

(2015) Hena Khanam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potential of aryl–urea–benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease

(2015) Belma Zengin Kurt et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors

(2015) Farzaneh Baharloo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure-activity relationship study of benzofuran-based chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors

(2015) Manizheh Mostofi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioactive benzofuran derivatives: Moracins A–Z in medicinal chemistry

(2015) Ravi Naik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological and medicinal significance of benzofuran

(2015) Reshma J. Nevagi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer’s Disease

(2015) Zhiren Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

(2015) Xiaoming Zha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organic Carbamates in Drug Design and Medicinal Chemistry

(2015) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aβ42 and Aβ40: similarities and differences

(2015) Tian Qiu et al.   JOURNAL OF PEPTIDE SCIENCE

Amyloid-β11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials

(2015) Enchi Liu et al.   NEUROLOGY

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau

(2015) Katja Hochgräfe et al.   Acta Neuropathologica Communications

Benzofuran-Chalcone Hybrids as Potential Multifunctional Agents against Alzheimer’s Disease: Synthesis and in vivo Studies with TransgenicCaenorhabditis elegans

(2014) Koneni V. Sashidhara et al.   ChemMedChem

Radiolabeled bioactive benzoheterocycles for imaging β-amyloid plaques in Alzheimer's disease

(2014) Yanping Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

(2014) Oscar M. Bautista-Aguilera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of new isoxazoline derivatives from harmine and evaluation of their anti-Alzheimer, anti-cancer and anti-inflammatory activities

(2014) Insaf Filali et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

New Melatonin–N,N-Dibenzyl(N-methyl)amine Hybrids: Potent Neurogenic Agents with Antioxidant, Cholinergic, and Neuroprotective Properties as Innovative Drugs for Alzheimer’s Disease

(2014) Beatriz López-Iglesias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol

(2014) Fei Mao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aminostyrylbenzofuran Directly Reduces Oligomeric Amyloid-β and Reverses Cognitive Deficits in Alzheimer Transgenic Mice

(2014) Sang-Hyun Lee et al.   PLoS One

D-amino acid-based peptide inhibitors as early or preventative therapy in Alzheimer disease

(2014) Jitendra Kumar et al.   Prion

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease

(2014) Kelly Willemijn Menting et al.   Frontiers in Aging Neuroscience

A phase II study of the gamma-secretase inhibitor avagacestat (BMS-708163) in predementia Alzheimer's disease

(2013) Vlad Coric et al.   Alzheimers & Dementia

Tau-aggregation inhibitor therapy for Alzheimer's disease

(2013) Claude M. Wischik et al.   BIOCHEMICAL PHARMACOLOGY

2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of β-amyloid aggregation

(2013) Yun Suk Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cover Picture: (Chem. Eur. J. 1/2014)

(2013)   CHEMISTRY-A EUROPEAN JOURNAL

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives

(2013) Dimitra Hadjipavlou-Litina et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012)

(2013) Federica Belluti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Benzofuran derivatives: a patent review

(2013) Kamal M Dawood   EXPERT OPINION ON THERAPEUTIC PATENTS

Bioactive stilbenes fromVitis viniferagrapevine shoots extracts

(2013) Nassima Chaher et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model

(2013) Cai-Xia Peng et al.   NEUROBIOLOGY OF AGING

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-Assembled Peptide-Polyoxometalate Hybrid Nanospheres: Two in One Enhances Targeted Inhibition of Amyloid β-Peptide Aggregation Associated with Alzheimer's Disease

(2013) Meng Li et al.   Small

Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease

(2012) Vladimir Coric et al.   ARCHIVES OF NEUROLOGY

Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor

(2012) Shang-Ke Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Evaluation of Bioactive Small Molecules

(2012) Duy H. Hua   CHEMICAL RECORD

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Heterocycles in drugs and drug discovery

(2012) A. Gomtsyan   Chemistry of Heterocyclic Compounds

Was Phenserine a Failure or Were Investigators Mislead by Methods?

(2012) Robert E. Becker et al.   Current Alzheimer Research

Editorial [The Multifactorial Nature of Alzheimers Disease and Related Therapeutic Strategies (Executive Editors: Maria do Carmo Carreiras and Jose Marco-Contelles)]

(2012) Maria do Carmo Carreiras et al.   CURRENT PHARMACEUTICAL DESIGN

Peptides for Therapy and Diagnosis of Alzheimer's Disease

(2012) Susanne Aileen Funke et al.   CURRENT PHARMACEUTICAL DESIGN

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents

(2012) Stefano Rizzo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation

(2012) Heiko Kroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling

(2012) Zeng Li et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE

(2012) Gerard Esteban et al.   JOURNAL OF NEURAL TRANSMISSION

Highly selective inhibition of butyrylcholinesterase by a novel melatonin-tacrine heterodimers

(2012) Anna Zawadzka et al.   JOURNAL OF PINEAL RESEARCH

A Survey of Peptides with Effective Therapeutic Potential in Alzheimer’s Disease Rodent Models or in Human Clinical Studies

(2012) N. Sun et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

From BACE1 Inhibitor to Multifunctionality of Tryptoline and Tryptamine Triazole Derivatives for Alzheimer’s Disease

(2012) Jutamas Jiaranaikulwanitch et al.   MOLECULES

Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD

(2012) Carolina García-Barroso et al.   NEUROPHARMACOLOGY

Cholinesterase inhibitors and memantine for symptomatic treatment of dementia

(2012) J. Rodda et al.   BMJ-British Medical Journal

Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease

(2011) Qin Nie et al.   ACTA PHARMACOLOGICA SINICA

Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry

(2011) Tristan Richard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer’s disease

(2011) Huailei Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

(2011) Evelin L. Schaeffer et al.   Clinics

Alzheimer's Disease: Emerging Trends in Small Molecule Therapies

(2011) T. Mohamed et al.   CURRENT MEDICINAL CHEMISTRY

Chemical Biology, Molecular Mechanism and Clinical Perspective of γ - Secretase Modulators in Alzheimers Disease

(2011) Bruno Bulic et al.   Current Neuropharmacology

Editorial [Hot Topic: The Complex and Multifactorial Nature of Alzheimers Disease (Guest Editors: Karim Alkadhi and Jason Eriksen)]

(2011) Karim Alkadhi et al.   Current Neuropharmacology

Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans

(2011) Kopal Saharia et al.   EXPERIMENTAL GERONTOLOGY

Benzofurans fromStyrax agrestisAs Acetylcholinesterase Inhibitors: Structure–Activity Relationships and Molecular Modeling Studies

(2011) Jiawei Liu et al.   JOURNAL OF NATURAL PRODUCTS

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

(2011) Tomohiro Onishi et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease: β-amyloid plaque formation in human brain

(2011) Philip Seeman et al.   SYNAPSE

The worldwide societal costs of dementia: Estimates for 2009

(2010) Anders Wimo et al.   Alzheimers & Dementia

Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

(2010) Maria Laura Bolognesi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

From Anti-allergic to Anti-Alzheimer ’ s: Molecular Pharmacology of Dimebon™

(2010) I. Okun et al.   Current Alzheimer Research

Eprosartan

(2010) Greg L. Plosker   DRUGS

Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease  - and  -Secretase via Distinct Mechanisms

(2010) S. Mitterreiter et al.   JOURNAL OF NEUROSCIENCE

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase

(2010) Xiang Zhou et al.   MOLECULES

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

New stilbene dimers against amyloid fibril formation

(2009) Céline Rivière et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease

(2009) Lauren E. Scott et al.   CHEMICAL REVIEWS

Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

(2009) María Isabel Fernández-Bachiller et al.   ChemMedChem

Developments of Indoles as Anti-HIV-1 Inhibitors

(2009) Hui Xu et al.   CURRENT PHARMACEUTICAL DESIGN

Optimal Dosing of Galantamine in Patients with Mild or Moderate Alzheimerʼs Disease

(2009) Stephen Aronson et al.   DRUGS & AGING

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation

(2009) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Reserpine can confer stress tolerance and lifespan extension in the nematode C. elegans

(2008) Deepti Srivastava et al.   BIOGERONTOLOGY

Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation

(2008) Ji Hun Byun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apaziquone for non-muscle invasive bladder cancer: a critical review

(2008) J Alfred Witjes et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, β Amyloid Aggregation, and Aβ Neurotoxicity

(2008) Stefano Rizzo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis

(2008) Mohammad A. Kamal et al.   JOURNAL OF NEURAL TRANSMISSION

The oxidation products of melatonin derivatives exhibit acetylcholinesterase and butyrylcholinesterase inhibitory activity

(2008) Aleksandra Siwicka et al.   JOURNAL OF PINEAL RESEARCH

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor

(2006) J Meunier et al.   BRITISH JOURNAL OF PHARMACOLOGY