Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

Melatonin and brain inflammaging

(2015) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

(2015) Lloyd A. Demetrius et al.   Frontiers in Physiology

Chronic exposure to aluminum and melatonin through the diet: Neurobehavioral effects in a transgenic mouse model of Alzheimer disease

(2014) Celeste Di Paolo et al.   FOOD AND CHEMICAL TOXICOLOGY

Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2–ARE signaling pathway as a potential mechanism

(2014) Ke Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17

(2014) Mayuri Shukla et al.   JOURNAL OF PINEAL RESEARCH

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

(2014) Jakob Domert et al.   NEUROBIOLOGY OF DISEASE

Genetic deletion of MT1/MT2 melatonin receptors enhances murine cognitive and motor performance

(2014) G. O’Neal-Moffitt et al.   NEUROSCIENCE

Age-Related Mitochondrial Alterations without Neuronal Loss in the Hippocampus of a Transgenic Model of Alzheimer's Disease

(2013) Mar Cuadrado-Tejedor et al.   Current Alzheimer Research

Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology

(2013) Russel J. Reiter et al.   HUMAN REPRODUCTION UPDATE

Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin

(2013) Giuseppe Petrosillo et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

(2013) A. Bobba et al.   MITOCHONDRION

Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model

(2013) Cai-Xia Peng et al.   NEUROBIOLOGY OF AGING

Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?

(2012) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

Circadian System Functionality, Hippocampal Oxidative Stress, and Spatial Memory in the APPswe/PS1dE9 Transgenic Model of Alzheimer Disease: Effects of Melatonin or Ramelteon

(2012) Beatriz Baño Otalora et al.   CHRONOBIOLOGY INTERNATIONAL

From Mitochondrial Dysfunction to Amyloid Beta Formation: Novel Insights into the Pathogenesis of Alzheimer’s Disease

(2012) Kristina Leuner et al.   MOLECULAR NEUROBIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

(2012) Seithikurippu R. Pandi-Perumal et al.   NEUROTOXICITY RESEARCH

Accumulation of Exogenous Amyloid-BetaPeptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin

(2012) Sergio Rosales-Corral et al.   Oxidative Medicine and Cellular Longevity

Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam

(2012) Rafael Ochoa-Sanchez et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

Melatonin increases dendritogenesis in the hilus of hippocampal organotypic cultures

(2011) A. Domínguez-Alonso et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice

(2011) Merina Varghese et al.   Translational Neuroscience

Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex

(2010) Xue-Mei Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated mice

(2010) Rosalia Crupi et al.   JOURNAL OF PINEAL RESEARCH

Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice

(2010) G.L. Poirier et al.   NEUROSCIENCE

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

(2010) M. L. Dubocovich et al.   PHARMACOLOGICAL REVIEWS

Genetic variation of melatonin productivity in laboratory mice under domestication

(2010) T. Kasahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin: Action as antioxidant and potential applications in human disease and aging

(2010) Dominique Bonnefont-Rousselot et al.   TOXICOLOGY

Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine

(2009) Joanne Rodda et al.   INTERNATIONAL PSYCHOGERIATRICS

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease

(2009) James M. Olcese et al.   JOURNAL OF PINEAL RESEARCH

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

(2009) Carla M. Yuede et al.   NEUROBIOLOGY OF DISEASE

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective activation of melatonin receptors with ramelteon improves liver function and hepatic perfusion after hemorrhagic shock in rat

(2008) Alexander M. Mathes et al.   CRITICAL CARE MEDICINE

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

(2008) Rosa Resende et al.   FREE RADICAL BIOLOGY AND MEDICINE

Preoperative Anxiolytic Effect of Melatonin and Clonidine on Postoperative Pain and Morphine Consumption in Patients Undergoing Abdominal Hysterectomy: A Double-Blind, Randomized, Placebo-Controlled Study

(2008) Wolnei Caumo et al.   JOURNAL OF PAIN

Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice

(2008) Beatriz Caballero et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

(2008) Ana López et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents amyloid protofibrillar induced oxidative imbalance and biogenic amine catabolism

(2008) Masilamoni J. Gunasingh et al.   LIFE SCIENCES

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING

Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats

(2008) Dafne García-Chávez et al.   NEUROSCIENCE LETTERS

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL