PATHOLOGICAL TAU AND REACTIVE ASTROGLIOSIS ARE ASSOCIATED WITH DISTINCT FUNCTIONAL DEFICITS IN A MOUSE MODEL OF TAUOPATHY.

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

(2021) Pablo Largo-Barrientos et al.   NEURON

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state

(2021) Anastasie Maté de Gérando et al.   BRAIN

Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation

(2020) Nathalie Daude et al.   ACTA NEUROPATHOLOGICA

Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease

(2020) Maura Malpetti et al.   BRAIN

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

(2020) Shorena Janelidze et al.   Nature Communications

A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

(2020) Xavier Taylor et al.   Journal of Neuroinflammation

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Vascular amyloid accumulation alters the gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy

(2020) Pablo Cisternas et al.   AGING CELL

Tau at the interface between neurodegeneration and neuroinflammation

(2020) Alessandro Didonna   GENES AND IMMUNITY

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

(2019) Yingjian You et al.   Acta Neuropathologica Communications

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

(2018) Sarah L. DeVos et al.   Frontiers in Neuroscience

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

Practical considerations for choosing a mouse model of Alzheimer’s disease

(2017) Joanna L. Jankowsky et al.   Molecular Neurodegeneration

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperphosphorylated Tau is a Cause of Neuronal Dysfunction in Tauopathy

(2017) Akihiko Takashima   JOURNAL OF ALZHEIMERS DISEASE

Potential mechanisms and implications for the formation of tau oligomeric strains

(2016) Julia E. Gerson et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model

(2016) Cristian A. Lasagna-Reeves et al.   NEURON

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

(2015) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Tau Propagation, Different Tau Phenotypes, and Prion-like Properties of Tau

(2014) Bradley T. Hyman   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Mouse Model of Penetrating Brain Injury

(2014) Ibolja Cernak et al.   Frontiers in Neurology

A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans

(2013) Jocelyne C. Whitehead et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model

(2011) Astrid Sydow et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

(2011) Hiroki Takeuchi et al.   PLoS One

Hypothermia and Alzheimers Disease Neuropathogenic Pathways

(2010) R. A. Whittington et al.   Current Alzheimer Research

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Molecular Mechanisms of Prion Pathogenesis

(2008) Adriano Aguzzi et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanism of Tau-Induced Neurodegeneration in Alzheimer Disease and Related Tauopathies

(2008) Alejandra del Alonso et al.   Current Alzheimer Research

Knock-out and transgenic mouse models of tauopathies

(2007) Franziska Denk et al.   NEUROBIOLOGY OF AGING