Template and primer requirements for DNA Pol θ-mediated end joining

Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism

(2018) Wei Yang et al.   Annual Review of Biochemistry

Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes

(2018) Lepakshi Ranjha et al.   CHROMOSOMA

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual loss of human POLQ and LIG4 abolishes random integration

(2017) Shinta Saito et al.   Nature Communications

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

(2017) Alex N. Zelensky et al.   Nature Communications

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA polymerase θ (POLQ), double-strand break repair, and cancer

(2016) Richard D. Wood et al.   DNA REPAIR

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

(2016) David W. Wyatt et al.   MOLECULAR CELL

Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

(2016) Tatiana Kent et al.   eLife

Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair

(2015) J. Gouge et al.   EMBO JOURNAL

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis

(2015) Young-Sam Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

(2015) Joseph A. Newman et al.   STRUCTURE

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis

(2015) Young-Sam Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

(2014) S. F. Roerink et al.   GENOME RESEARCH

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

DNA polymerase POLQ and cellular defense against DNA damage

(2012) Matthew J. Yousefzadeh et al.   DNA REPAIR

Promiscuous DNA synthesis by human DNA polymerase θ

(2011) Matthew Hogg et al.   NUCLEIC ACIDS RESEARCH

Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts

(2010) Matthew Hogg et al.   JOURNAL OF MOLECULAR BIOLOGY