Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response

Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation

(2019) Eva Malacaria et al.   Nature Communications

Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements

(2018) Carlos Mendez-Dorantes et al.   GENES & DEVELOPMENT

C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains

(2018) Ragini Bhargava et al.   Nature Communications

The concerted roles of FANCM and Rad52 in the protection of common fragile sites

(2018) Hailong Wang et al.   Nature Communications

Human RAD52 interactions with replication protein A and the RAD51 presynaptic complex

(2017) Chu Jian Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM

(2017) Yi Zhou et al.   MOLECULAR CELL

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

(2017) Alex N. Zelensky et al.   Nature Communications

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination

(2017) Ineke Brouwer et al.   Cell Reports

DNA polymerase θ (POLQ), double-strand break repair, and cancer

(2016) Richard D. Wood et al.   DNA REPAIR

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

(2016) David W. Wyatt et al.   MOLECULAR CELL

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

(2016) Sotirios K. Sotiriou et al.   MOLECULAR CELL

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells

(2016) Annabel Quinet et al.   NUCLEIC ACIDS RESEARCH

Regulation of Single-Strand Annealing and its Role in Genome Maintenance

(2016) Ragini Bhargava et al.   TRENDS IN GENETICS

Linking DNA polymerase theta structure and function in health and disease

(2015) Kelly Beagan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies

(2015) Jordi Carreras Puigvert et al.   FEBS Journal

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Contribution of Alu Elements to Mutagenic DNA Double-Strand Break Repair

(2015) Maria E. Morales et al.   PLoS Genetics

An update on PARP inhibitors—moving to the adjuvant setting

(2014) Amir Sonnenblick et al.   Nature Reviews Clinical Oncology

An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells

(2014) Meilen C. Muñoz et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic Advancement

(2012) B. H. Lok et al.   CLINICAL CANCER RESEARCH

There and back again: new single-molecule insights in the motion of DNA repair proteins

(2012) Maria Spies   CURRENT OPINION IN STRUCTURAL BIOLOGY

DNA polymerase POLQ and cellular defense against DNA damage

(2012) Matthew J. Yousefzadeh et al.   DNA REPAIR

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

(2011) Masayoshi Honda et al.   EMBO JOURNAL

A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

(2011) C. Cotta-Ramusino et al.   SCIENCE

Collaboration and competition between DNA double-strand break repair pathways

(2010) Elizabeth M. Kass et al.   FEBS LETTERS

Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts

(2010) Matthew Hogg et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes

(2010) Jill M. Grimme et al.   NUCLEIC ACIDS RESEARCH

Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes

(2008) E. Rothenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA