Mechanistic basis for microhomology identification and genome scarring by polymerase theta
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Title
Mechanistic basis for microhomology identification and genome scarring by polymerase theta
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 15, Pages 8476-8485
Publisher
Proceedings of the National Academy of Sciences
Online
2020-04-01
DOI
10.1073/pnas.1921791117
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Note: Only part of the references are listed.- Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining
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- Genetic determinants of cellular addiction to DNA polymerase theta
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- Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
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- Rad51-mediated double-strand break repair and mismatch correction of divergent substrates
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- Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks
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- Dual loss of human POLQ and LIG4 abolishes random integration
- (2017) Shinta Saito et al. Nature Communications
- Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA
- (2017) Alex N. Zelensky et al. Nature Communications
- Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks
- (2016) David W. Wyatt et al. MOLECULAR CELL
- Landscape of somatic mutations in 560 breast cancer whole-genome sequences
- (2016) Serena Nik-Zainal et al. NATURE
- Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining
- (2016) Robin van Schendel et al. PLoS Genetics
- Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
- (2015) Raphael Ceccaldi et al. NATURE
- Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
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- (2015) Tatiana Kent et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Nonhomologous end joining: A good solution for bad ends
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- Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
- (2014) Steven Lin et al. eLife
- Repair of Strand Breaks by Homologous Recombination
- (2013) M. Jasin et al. Cold Spring Harbor Perspectives in Biology
- Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
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- Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions
- (2010) Amy Marie Yu et al. NUCLEIC ACIDS RESEARCH
- DNA polymerase up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability
- (2010) F. Lemee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila
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