Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

KAMO: towards automated data processing for microcrystals

(2018) Keitaro Yamashita et al.   Acta Crystallographica Section D-Structural Biology

Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A: Identification of Thermostabilizing Mutations Followed by Determination of Three-Dimensional Structures for Two Example Receptors

(2017) Satoshi Yasuda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure of the full-length glucagon class B G-protein-coupled receptor

(2017) Haonan Zhang et al.   NATURE

Structural insight into allosteric modulation of protease-activated receptor 2

(2017) Robert K. Y. Cheng et al.   NATURE

Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

(2017) Catherine J. Hutchings et al.   NATURE REVIEWS DRUG DISCOVERY

First Clinical Experience with ONO-4232: A Randomized, Double-blind, Placebo-controlled Healthy Volunteer Study of a Novel Lusitropic Agent for Acutely Decompensated Heart Failure

(2016) Caroline L. Ward et al.   CLINICAL THERAPEUTICS

A Prospective, Randomized, Masked, Placebo-Controlled Multisite Clinical Study of Grapiprant, an EP4 Prostaglandin Receptor Antagonist (PRA), in Dogs with Osteoarthritis

(2016) L. Rausch-Derra et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

The intervening removable affinity tag (iRAT) production system facilitates Fv antibody fragment-mediated crystallography

(2016) Yayoi Nomura et al.   PROTEIN SCIENCE

How Can Mutations Thermostabilize G-Protein-Coupled Receptors?

(2016) Nagarajan Vaidehi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor

(2016) Nathaniel Stanley et al.   Scientific Reports

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

(2015) Jill E. Chrencik et al.   CELL

KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration

(2015) Yusuke Watanabe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor

(2015) Kalli Kappel et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Combination of EP4 antagonist and checkpoint inhibitors promotes anti-tumor effector T cells in preclinical tumor models

(2015) Xingfeng Bao et al.   Journal for ImmunoTherapy of Cancer

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

(2014) Ankita Srivastava et al.   NATURE

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography

(2013) James Foadi et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

(2013) David A Hinds et al.   NATURE GENETICS

Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae

(2012) Mitsunori Shiroishi et al.   Microbial Cell Factories

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Prostanoid Receptors

(2011) Takako Hirata et al.   CHEMICAL REVIEWS

ANODE: anomalous and heavy-atom density calculation

(2011) Andrea Thorn et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1

(2011) Yongyong Shi et al.   NATURE GENETICS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands

(2009) M. Leduc et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols