Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation

BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease

(2018) Evelyn Ullrich et al.   JOURNAL OF CLINICAL INVESTIGATION

Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut

(2017) Sebastian Zundler et al.   GASTROENTEROLOGY

Pathogenic T cell subsets in allergic and chronic inflammatory bowel disorders

(2017) Sebastian Zundler et al.   IMMUNOLOGICAL REVIEWS

Novel Insights into the Mechanisms of Gut Homing and Antiadhesion Therapies in Inflammatory Bowel Diseases

(2017) Sebastian Zundler et al.   INFLAMMATORY BOWEL DISEASES

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

(2017) James C Lee et al.   NATURE GENETICS

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

Environmental triggers in IBD: a review of progress and evidence

(2017) Ashwin N. Ananthakrishnan et al.   Nature Reviews Gastroenterology & Hepatology

Transcriptional Regulation of Tissue-Resident Lymphocytes

(2017) Laura K. Mackay et al.   TRENDS IN IMMUNOLOGY

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells

(2017) Anna E. Oja et al.   Frontiers in Immunology

Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity

(2017) Femke Stelma et al.   Scientific Reports

Blockade of αEβ7 integrin suppresses accumulation of CD8+and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo

(2016) Sebastian Zundler et al.   GUT

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation

(2016) Rocío López-Posadas et al.   JOURNAL OF CLINICAL INVESTIGATION

Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells

(2016) Judith F. Ashouri et al.   JOURNAL OF IMMUNOLOGY

Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy

(2016) Anika Klingberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans

(2015) Felipe A. Vieira Braga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

(2015) Anika Fischer et al.   GUT

The emerging role of resident memory T cells in protective immunity and inflammatory disease

(2015) Chang Ook Park et al.   NATURE MEDICINE

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8 + T Cells, Facilitating Protection from Local Cytomegalovirus Infection

(2015) Jenny Tosca Thom et al.   Cell Reports

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

(2014) Brian S. Sheridan et al.   IMMUNITY

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial

(2014) Séverine Vermeire et al.   LANCET

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

(2014) Katharina Gerlach et al.   NATURE IMMUNOLOGY

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology

(2014) Damian Lanz Turner et al.   Frontiers in Immunology

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation

(2012) Klaas P J M van Gisbergen et al.   NATURE IMMUNOLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells

(2009) S. Hong et al.   JOURNAL OF IMMUNOLOGY

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

Novel therapeutic targets in the treatment of IBD

(2008) Arthur Kaser et al.   EXPERT OPINION ON THERAPEUTIC TARGETS