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Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

(2021) Ruilin Tian et al.   NATURE NEUROSCIENCE

Contributions of DNA Damage to Alzheimer’s Disease

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Cellular Senescence in Neurodegenerative Diseases

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Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression

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Transcriptomics in Alzheimer’s Disease: Aspects and Challenges

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IPSC-Derived Neuronal Cultures Carrying the Alzheimer’s Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network

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CRISPR-based functional genomics for neurological disease

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Biomolecular Condensates in the Nucleus

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Insights into HP1a-Chromatin Interactions

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Tau affects P53 function and cell fate during the DNA damage response

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Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems

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RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

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Genomic Enhancers in Brain Health and Disease

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MicroRNAs in Alzheimer’s Disease

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Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1+/− mice

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Hippocampal LMNA Gene Expression is Increased in Late-Stage Alzheimer’s Disease

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Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease

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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

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Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s Disease

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Nuclear Organization in Stress and Aging

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CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

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Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer’s patients

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Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

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Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

(2019) Yi-Chen Hsieh et al.   Cell Reports

Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood

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Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

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Marked Diversity of Unique Cortical Enhancers Enables Neuron-Specific Tools by Enhancer-Driven Gene Expression

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An atlas of chromatin accessibility in the adult human brain

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Overactive BRCA1 Affects Presenilin 1 in Induced Pluripotent Stem Cell-Derived Neurons in Alzheimer’s Disease

(2018) Michalina Wezyk et al.   JOURNAL OF ALZHEIMERS DISEASE

Id1 and Sonic Hedgehog Mediate Cell Cycle Reentry and Apoptosis Induced by Amyloid Beta-Peptide in Post-mitotic Cortical Neurons

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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

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Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression

(2018) Qinyu Sun et al.   TRENDS IN GENETICS

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(2018) Dingfeng Li et al.   Nature Communications

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates

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Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer’s Disease

(2018) Warren Winick-Ng et al.   Frontiers in Molecular Neuroscience

Chromatin Architectural Changes during Cellular Senescence and Aging

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Tau protein aggregation is associated with cellular senescence in the brain

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

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Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

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Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction

(2018) Mahmoud B. Maina et al.   Frontiers in Cellular Neuroscience

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

(2018) Gilles Gasparoni et al.   Epigenetics & Chromatin

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CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease

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Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

(2018) Hans-Ulrich Klein et al.   NATURE NEUROSCIENCE

A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex

(2018) Sarah J. Marzi et al.   NATURE NEUROSCIENCE

Alzheimer's disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study

(2018) Hernán Guillermo Hernández et al.   Epigenomics

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

Pseudoexfoliation and Alzheimer’s associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression

(2017) Biswajit Padhy et al.   HUMAN MOLECULAR GENETICS

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

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An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

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ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

(2017) Diego Mastroeni et al.   PLoS One

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease

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The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer’s disease

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Coexisting Liquid Phases Underlie Nucleolar Subcompartments

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Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

(2016) Bess Frost et al.   CURRENT BIOLOGY

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Age-related myelin degradation burdens the clearance function of microglia during aging

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Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases

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Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence

(2016) Elizabeth P. Crowe et al.   Frontiers in Aging Neuroscience

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

(2016) Corey T. Watson et al.   Genome Medicine

Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

(2016) Meryl S. Lillenes et al.   Molecular Brain

CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription

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Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS

(2015) J. M. Gray et al.   JOURNAL OF NEUROSCIENCE

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

The selection and function of cell type-specific enhancers

(2015) Sven Heinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease

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The epigenetics of aging and neurodegeneration

(2015) Roy Lardenoije et al.   PROGRESS IN NEUROBIOLOGY

Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease

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Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

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Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

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Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

(2014) Jill M. Dowen et al.   CELL

Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons

(2014) Yu-Hsing Hung et al.   MOLECULAR NEUROBIOLOGY

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

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(2014) Taeko Kimura et al.   Frontiers in Molecular Neuroscience

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

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PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage

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U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

(2013) B. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation

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Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease

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Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease

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An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

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Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Targeted proteomics for quantification of histone acetylation in Alzheimer's disease

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(2012) Michal Hetman et al.   TRENDS IN NEUROSCIENCES

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Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-β and prion peptides

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Enhancer function: new insights into the regulation of tissue-specific gene expression

(2011) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

Cell Cycle Proteins in Brain in Mild Cognitive Impairment: Insights into Progression to Alzheimer Disease

(2011) Jeriel T. R. Keeney et al.   NEUROTOXICITY RESEARCH

Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease

(2011) Maciej Pietrzak et al.   PLoS One

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

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Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease

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The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

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Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the Presenilin-1 Alzheimer's disease brain

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Evidence for natural antisense transcript-mediated inhibition of microRNA function

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TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing

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Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

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Histone H4 lysine 16 acetylation regulates cellular lifespan

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

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The Nun Study: Clinically silent AD, neuronal hypertrophy, and linguistic skills in early life

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Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

(2009) Diego Mastroeni et al.   PLoS One

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

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The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

(2008) Na-Hye Myung et al.   AGE

Different fibrillar Aβ 1–42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle

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Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of nucleolar transcription as a trigger for neuronal apoptosis

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Neuronal Hypertrophy in Asymptomatic Alzheimer Disease

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A  Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease

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Activation of an Endogenous Suicide Response after Perturbation of rRNA Synthesis Leads to Neurodegeneration in Mice

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Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

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