DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

(2018) Rebecca G. Smith et al.   Alzheimers & Dementia

Genome-Wide DNA Methylation Differences Between Late-Onset Alzheimer's Disease and Cognitively Normal Controls in Human Frontal Cortex

(2018) Kelly M. Bakulski et al.   JOURNAL OF ALZHEIMERS DISEASE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Correcting for cell-type heterogeneity in epigenome-wide association studies: revisiting previous analyses

(2017) Shijie C Zheng et al.   NATURE METHODS

Correcting for cell-type heterogeneity in DNA methylation: a comprehensive evaluation

(2017) Elior Rahmani et al.   NATURE METHODS

Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice

(2017) Alyssa Littlefield et al.   NEUROSCIENCE

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

(2017) Diego Mastroeni et al.   PLoS One

Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex

(2017) Chongyuan Luo et al.   SCIENCE

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

Variability of DNA Methylation within Schizophrenia Risk Loci across Subregions of Human Hippocampus

(2017) W. Ruzicka et al.   Genes

DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age

(2017) Alexey Kozlenkov et al.   Genes

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

Reference-free deconvolution of DNA methylation data and mediation by cell composition effects

(2016) E. Andres Houseman et al.   BMC BIOINFORMATICS

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study

(2016) L. Kananen et al.   BMC GENOMICS

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease

(2016) Ilaria Canobbio et al.   CELLULAR SIGNALLING

Long Non-coding RNA HOTAIR Promotes Parkinson';s Disease Induced by MPTP Through up-regulating the Expression of LRRK2

(2016) Sen Liu et al.   CURRENT NEUROVASCULAR RESEARCH

Impact ofPICALMandCLUon hippocampal degeneration

(2016) Xianfeng Yang et al.   HUMAN BRAIN MAPPING

Clusterin Binds to Aβ1–42Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation

(2016) Marten Beeg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HOXA5 localization in postnatal and adult mouse brain is suggestive of regulatory roles in postmitotic neurons

(2016) Benoit Lizen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

(2016) Elise Cuyvers et al.   LANCET NEUROLOGY

Epigenetics of dementia: understanding the disease as a transformation rather than a state

(2016) Bryan Maloney et al.   LANCET NEUROLOGY

Genome-wide significant risk factors for Alzheimer’s disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment

(2016) A Lacour et al.   MOLECULAR PSYCHIATRY

Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies

(2016) Elior Rahmani et al.   NATURE METHODS

Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease

(2016) Andrew J. Phipps et al.   NEUROBIOLOGY OF AGING

Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology

(2016) Gennady V. Roshchupkin et al.   NEUROBIOLOGY OF AGING

Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons

(2016) Naomi Habib et al.   SCIENCE

Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses

(2016) P Cunin et al.   Cell Death & Disease

Distinct promoters, subjected to epigenetic regulation, drive the expression of two clusterin mRNAs in prostate cancer cells

(2015) Martina Bonacini et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Clusterin gene is predominantly regulated by histone modifications in human colon cancer and ectopic expression of the nuclear isoform induces cell death

(2015) Moonmoon Deb et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aging and DNA methylation

(2015) Marc Jung et al.   BMC BIOLOGY

Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution

(2015) Jeffrey A. Gross et al.   BMC GENOMICS

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer’s Disease

(2015) Meng Qian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Improved age determination of blood and teeth samples using a selected set of DNA methylation markers

(2015) Bram Bekaert et al.   Epigenetics

Profiling of methylation and demethylation pathways during brain development and ageing

(2015) Theo F. J. Kraus et al.   JOURNAL OF NEURAL TRANSMISSION

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease

(2015) Tammaryn Lashley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Substantial DNA methylation differences between two major neuronal subtypes in human brain

(2015) Alexey Kozlenkov et al.   NUCLEIC ACIDS RESEARCH

NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice

(2015) Keita Sasaki et al.   Molecular Brain

Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma

(2015) Sebastian Kurscheid et al.   GENOME BIOLOGY

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

(2015) Adam Labadorf et al.   PLoS One

Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs

(2014) Wilma T. Steegenga et al.   AGE

Interactions between Aβ oligomers and presynaptic cholinergic signaling: Age-dependent effects on attentional capacities

(2014) Vinay Parikh et al.   BEHAVIOURAL BRAIN RESEARCH

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

Reference-free cell mixture adjustments in analysis of DNA methylation data

(2014) Eugene Andres Houseman et al.   BIOINFORMATICS

Applying Epigenetics to Alzheimer’s Disease via the Latent Early–life Associated Regulation (LEARn) Model

(2014) Bryan Maloney et al.   Current Alzheimer Research

Simplet/Fam53b is required for Wnt signal transduction by regulating  -catenin nuclear localization

(2014) C. Kizil et al.   DEVELOPMENT

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Upregulation of APP, ADAM10 and ADAM17 in the Denervated Mouse Dentate Gyrus

(2014) Domenico Del Turco et al.   PLoS One

Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease

(2014) Yuan Zhou et al.   PLoS One

MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis

(2014) Andrew G. Hoss et al.   PLoS Genetics

Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain

(2014) Lu Wen et al.   GENOME BIOLOGY

Amyloid or tau: the chicken or the egg?

(2013) David M. A. Mann et al.   ACTA NEUROPATHOLOGICA

Amyloid and tau: neither chicken nor egg but two partners in crime!

(2013) Johannes Attems et al.   ACTA NEUROPATHOLOGICA

Pathview: an R/Bioconductor package for pathway-based data integration and visualization

(2013) Weijun Luo et al.   BIOINFORMATICS

A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression

(2013) Jerry Guintivano et al.   Epigenetics

Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation

(2013) Atsushi Iwata et al.   HUMAN MOLECULAR GENETICS

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization

(2013) Polyxeni Philippidou et al.   NEURON

IL1RAPL1 Associated with Mental Retardation and Autism Regulates the Formation and Stabilization of Glutamatergic Synapses of Cortical Neurons through RhoA Signaling Pathway

(2013) Takashi Hayashi et al.   PLoS One

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Untangling the role of tau in Alzheimer’s disease: A unifying hypothesis

(2013) Neha Bhatia et al.   Translational Neuroscience

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

(2012) Shusuke Numata et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epigenetic and immunohistochemical characterization of the Clusterin gene in ovarian tumors

(2012) Guofen Yang et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

(2012) M. E. Hamby et al.   JOURNAL OF NEUROSCIENCE

Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk

(2012) I-Fang Ling et al.   PLoS One

Preventing Alzheimer's Disease

(2012) D. J. Selkoe   SCIENCE

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

(2012) Matthew N Davies et al.   GENOME BIOLOGY

Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

(2011) Salvatore Cortellino et al.   CELL

Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

(2011) K. Iwamoto et al.   GENOME RESEARCH

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

CRM1 Protein-mediated Regulation of Nuclear Clusterin (nCLU), an Ionizing Radiation-stimulated, Bax-dependent Pro-death Factor

(2011) Konstantin S. Leskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Roles for G-protein γ3and γ7Subtypes in Seizure Susceptibility as Revealed in Double Knock-out Mice

(2011) William F. Schwindinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

(2010) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing

(2010) Yun Huang et al.   PLoS One

DNA Methylation of Alzheimer Disease and Tauopathy-Related Genes in Postmortem Brain

(2009) Marta Barrachina et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

(2009) D K Lahiri et al.   MOLECULAR PSYCHIATRY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Isolation of neuronal chromatin from brain tissue

(2008) Yan Jiang et al.   BMC NEUROSCIENCE

Clusterin is epigenetically regulated in prostate cancer

(2008) Hanna E. Rauhala et al.   INTERNATIONAL JOURNAL OF CANCER