(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

(2020) Hiraku Takada et al.   Frontiers in Microbiology

A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes

(2020) Hedvig Tamman et al.   Nature Chemical Biology

A widespread toxin−antitoxin system exploiting growth control via alarmone signaling

(2020) Steffi Jimmy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional plasticity and evolutionary adaptation of allosteric regulation

(2020) Megan Leander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel

(2020) Patrick Pausch et al.   Cell Reports

Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis

(2020) Hiraku Takada et al.   NUCLEIC ACIDS RESEARCH

The Rel stringent factor from Thermus thermophilus: crystallization and X-ray analysis

(2019) Katleen Van Nerom et al.   Acta Crystallographica Section F-Structural Biology Communications

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

(2019) Kathryn Jane Turnbull et al.   Frontiers in Microbiology

The Molecular Origin of Enthalpy/Entropy Compensation in Biomolecular Recognition

(2018) Jerome M. Fox et al.   Annual Review of Biophysics

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA

(2018) Pavel Kudrin et al.   NUCLEIC ACIDS RESEARCH

Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest

(2018) Victoriia Murina et al.   NUCLEIC ACIDS RESEARCH

Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ

(2018) Wieland Steinchen et al.   Scientific Reports

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor

(2017) Jelena Beljantseva et al.   Scientific Reports

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribosome-dependent activation of stringent control

(2016) Alan Brown et al.   NATURE

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

(2016) Stefan Arenz et al.   NUCLEIC ACIDS RESEARCH

Ribosome•RelA structures reveal the mechanism of stringent response activation

(2016) Anna B Loveland et al.   eLife

Diversity in (p)ppGpp metabolism and effectors

(2015) Kuanqing Liu et al.   CURRENT OPINION IN MICROBIOLOGY

Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis

(2015) Anthony O. Gaca et al.   JOURNAL OF BACTERIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Entropy-Enthalpy Compensation: Role and Ramifications in Biomolecular Ligand Recognition and Design

(2013) John D. Chodera et al.   Annual Review of Biophysics

The ribosome triggers the stringent response by RelA via a highly distorted tRNA

(2013) Xabier Agirrezabala et al.   EMBO REPORTS

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

(2012) Viktoriya Shyp et al.   EMBO REPORTS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

(2012) Jae-Seong Yang et al.   PLoS Computational Biology

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Coupling of Domain Swapping to Kinetic Stability in a Thioredoxin Mutant

(2008) Abel Garcia-Pino et al.   JOURNAL OF MOLECULAR BIOLOGY