Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

Coevolutionary Analysis Enabled Rational Deregulation of Allosteric Enzyme Inhibition in Corynebacterium glutamicum for Lysine Production

(2011) Zhen Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineering the pentose phosphate pathway to improve hydrogen yield in recombinant Escherichia coli

(2011) Young Mi Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Active-site remodelling in the bifunctional fructose-1,6-bisphosphate aldolase/phosphatase

(2011) Juan Du et al.   NATURE

Protein engineering: navigating between chance and reason

(2011) Monya Baker   NATURE METHODS

Kinetic and CD/MCD Spectroscopic Studies of the Atypical, Three-His-Ligated, Non-Heme Fe2+Center in Diketone Dioxygenase: The Role of Hydrophilic Outer Shell Residues in Catalysis

(2010) Grit D. Straganz et al.   BIOCHEMISTRY

Advanced biofuel production in microbes

(2010) Pamela P. Peralta-Yahya et al.   Biotechnology Journal

Optimizing non-natural protein function with directed evolution

(2010) Eric M Brustad et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Understanding fatty acid synthesis in developing maize embryos using metabolic flux analysis

(2010) Ana Paula Alonso et al.   METABOLIC ENGINEERING

ASD: a comprehensive database of allosteric proteins and modulators

(2010) Z. Huang et al.   NUCLEIC ACIDS RESEARCH

Engineering Allosteric Regulation into Biological Catalysts

(2009) Jacques Fastrez   CHEMBIOCHEM

The structural basis of allosteric regulation in proteins

(2009) Roman A. Laskowski et al.   FEBS LETTERS

Ostreococcus tauriADP-glucose Pyrophosphorylase Reveals Alternative Paths for the Evolution of Subunit Roles

(2009) Misty L. Kuhn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

In the light of directed evolution: Pathways of adaptive protein evolution

(2009) J. D. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic diagnosis by whole exome capture and massively parallel DNA sequencing

(2009) Murim Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting Protein Ligand Binding Sites by Combining Evolutionary Sequence Conservation and 3D Structure

(2009) John A. Capra et al.   PLoS Computational Biology

Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins

(2009) Michael D. Daily et al.   PLoS Computational Biology

Role of Hydrophilic Residues in Proton Transfer during Catalysis by Human Carbonic Anhydrase II†‡

(2008) Jiayin Zheng et al.   BIOCHEMISTRY

Dihydrolipoamide Dehydrogenase Mutation Alters the NADH Sensitivity of Pyruvate Dehydrogenase Complex of Escherichia coli K-12

(2008) Y. Kim et al.   JOURNAL OF BACTERIOLOGY

The ConSurf-DB: pre-calculated evolutionary conservation profiles of protein structures

(2008) Ofir Goldenberg et al.   NUCLEIC ACIDS RESEARCH

Surface Sites for Engineering Allosteric Control in Proteins

(2008) J. Lee et al.   SCIENCE