A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells

Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan

(2016) Robin Sebastian et al.   CARCINOGENESIS

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain

(2016) Divyaanka Iyer et al.   FEBS Journal

Novel PARP inhibitors sensitize human leukemic cells in an endogenous PARP activity dependent manner

(2016) Mahesh Hegde et al.   RSC Advances

Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse

(2016) Elizabeth Thomas et al.   Scientific Reports

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis

(2016) Shikha Srivastava et al.   Scientific Reports

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

(2015) Mrinal Srivastava et al.   CHEMISTRY & BIOLOGY

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

(2015) Nicholas R. Brown et al.   Nature Communications

Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents

(2015) Arpit Katiyar et al.   RSC Advances

A novel benzimidazole derivative binds to the DNA minor groove and induces apoptosis in leukemic cells

(2015) Mahesh Hegde et al.   RSC Advances

Synthesis and antiproliferative activity of imidazo[2,1- b ][1,3,4]thiadiazole derivatives

(2014) Sujeet Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo

(2014) Yong Xia et al.   CANCER LETTERS

2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: Synthesis, cytotoxic activity and mechanism of action

(2014) Sujeet Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enhanced Efficacy of Pluronic Copolymer Micelle Encapsulated SCR7 against Cancer Cell Proliferation

(2014) Franklin John et al.   MACROMOLECULAR BIOSCIENCE

Sapodilla Plum (Achras sapota) Induces Apoptosis in Cancer Cell Lines and Inhibits Tumor Progression in Mice

(2014) Mrinal Srivastava et al.   Scientific Reports

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Melphalan in Regional Chemotherapy for Locally Recurrent Metastatic Melanoma

(2012) C.L. Defty et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice

(2012) Mahesh Hegde et al.   PLoS One

Extracts of Strawberry Fruits Induce Intrinsic Pathway of Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Mice

(2012) Ranganatha R. Somasagara et al.   PLoS One

A novel DNA intercalator, 8-methoxy pyrimido[4′,5′:4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor

(2011) Sheetal Sharma et al.   MOLECULAR CARCINOGENESIS

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents

(2009) D. S. Prasanna et al.   INVESTIGATIONAL NEW DRUGS

Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma

(2009) Jennifer A. Quinn et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification ofN-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design†

(2008) Paul G. Wyatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Elesclomol induces cancer cell apoptosis through oxidative stress

(2008) J. R. Kirshner et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY