Amyloid-β precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation

Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

(2021) Charles Arber et al.   Cell Reports

Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models

(2021) Marina Trombetta-Lima et al.   CELL CALCIUM

Presenilins and γ-Secretase in Membrane Proteostasis

(2019) Naoto Oikawa et al.   Cells

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy

(2019) Natalia N. Nalivaeva et al.   BRITISH JOURNAL OF PHARMACOLOGY

Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

(2019) Charles Arber et al.   MOLECULAR PSYCHIATRY

Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease

(2019) Oskar Hansson et al.   Alzheimers Research & Therapy

Depression in Alzheimer’s Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors?

(2019) Richard J. Elsworthy et al.   JOURNAL OF ALZHEIMERS DISEASE

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

Perspectives on Oxidative Stress in Alzheimer’s Disease and Predictions of Future Research Emphases

(2018) D. Allan Butterfield   JOURNAL OF ALZHEIMERS DISEASE

Platelets: Peripheral Biomarkers of Dementia?

(2018) Oluwatomi E.S. Akingbade et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal and Glial Differentiation of Human Neural Stem Cells Is Regulated by Amyloid Precursor Protein (APP) Levels

(2018) Raquel Coronel et al.   MOLECULAR NEUROBIOLOGY

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients

(2018) Julian H. Birnbaum et al.   Stem Cell Research

Correlation Between Mini-Mental State Examination and Platelet ADAM10 Expression in Alzheimer's Disease

(2018) Patrícia Regina Manzine et al.   JOURNAL OF ALZHEIMERS DISEASE

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells

(2017) N Gunhanlar et al.   MOLECULAR PSYCHIATRY

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Increased susceptibility to Aβ toxicity in neuronal cultures derived from familial Alzheimer’s disease (PSEN1-A246E) induced pluripotent stem cells

(2017) Enrique Armijo et al.   NEUROSCIENCE LETTERS

Presenilin-1 mutations and Alzheimer’s disease

(2017) Raymond J. Kelleher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

(2017) Anna Ochalek et al.   Alzheimers Research & Therapy

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease

(2017) Xin Wang et al.   Frontiers in Molecular Neuroscience

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

(2017) Minna Oksanen et al.   Stem Cell Reports

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Excess APPO-glycosylation by GalNAc-T6 decreases Aβ production

(2016) Keiko Akasaka-Manya et al.   JOURNAL OF BIOCHEMISTRY

Reference measurement procedure for CSF amyloid beta (Aβ)1-42and the CSF Aβ1-42/Aβ1-40ratio - a cross-validation study against amyloid PET

(2016) Josef Pannee et al.   JOURNAL OF NEUROCHEMISTRY

Stem cell-derived astrocytes: are they physiologically credible?

(2016) Eric Hill et al.   JOURNAL OF PHYSIOLOGY-LONDON

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series

(2016) Natalie S Ryan et al.   LANCET NEUROLOGY

Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation

(2016) Katarzyna Marta Zoltowska et al.   MOLECULAR MEDICINE

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1

(2016) Tong Li et al.   Stem Cell Research

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1

(2016) Tong Li et al.   Stem Cell Research

Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1

(2016) Anna Poon et al.   Stem Cell Research

Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1

(2016) Carlota Pires et al.   Stem Cell Research

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1

(2016) Alisa Tubsuwan et al.   Stem Cell Research

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations

(2016) Juan Yang et al.   Oncotarget

Threonine 576 residue of amyloid-β precursor protein regulates its trafficking and processing

(2015) Yoon Sun Chun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks

(2015) Amir M Hossini et al.   BMC GENOMICS

Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease

(2015) Dan Xia et al.   NEURON

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

(2014) Andrew A. Sproul et al.   PLoS One

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Increased in Vivo Amyloid- 42 Production, Exchange, and Loss in Presenilin Mutation Carriers

(2013) R. Potter et al.   Science Translational Medicine

The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells

(2013) Grace Woodruff et al.   Cell Reports

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease

(2012) Sascha Weggen et al.   Alzheimers Research & Therapy

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE