Depression in Alzheimer’s Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors?

Differential associations between depression and cognitive function in MCI and AD: a cross-sectional study

(2019) Chang Hyun Lee et al.   INTERNATIONAL PSYCHOGERIATRICS

Depression and Risk of Alzheimer's Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression

(2018) Damien Gallagher et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer’s Dementia in Individuals With Previous Depression

(2018) Claudia Bartels et al.   AMERICAN JOURNAL OF PSYCHIATRY

APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review

(2018) M. Clare O'Donoghue et al.   CORTEX

Dépression de la personne âgée ou maladie d’Alzheimer prodromique : quels outils pour le diagnostic différentiel ?

(2018) A.-I. Gasser et al.   ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

Protein levels of ADAM10, BACE1, and PSEN1 in platelets and leukocytes of Alzheimer’s disease patients

(2018) Jessyka Maria de França Bram et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Pharmacotherapy for the treatment of depression in patients with alzheimer’s disease: a treatment-resistant depressive disorder

(2018) Madia Lozupone et al.   EXPERT OPINION ON PHARMACOTHERAPY

Predictors of treatment outcome in depression in later life: A systematic review and meta-analysis

(2018) Chavit Tunvirachaisakul et al.   JOURNAL OF AFFECTIVE DISORDERS

Alzheimer’s Disease, Oligomers, and Inflammation

(2018) Gianluigi Forloni et al.   JOURNAL OF ALZHEIMERS DISEASE

Perspectives on Oxidative Stress in Alzheimer’s Disease and Predictions of Future Research Emphases

(2018) D. Allan Butterfield   JOURNAL OF ALZHEIMERS DISEASE

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals

(2018) Hsin-Yi Wu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

(2018) Sven J van der Lee et al.   LANCET NEUROLOGY

The spectrum of preclinical Alzheimer’s pathology and its modulation by ApoE genotype

(2018) Olga Pletnikova et al.   NEUROBIOLOGY OF AGING

Depressive disorders: Processes leading to neurogeneration and potential novel treatments

(2018) Gregory M. Brown et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The anti-inflammatory mechanism of antidepressants – SSRIs, SNRIs

(2018) Piotr Gałecki et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Advances in Pharmacotherapy of Late-Life Depression

(2018) John L. Beyer et al.   Current Psychiatry Reports

The Role of Fluoxetine in Activating Wnt/β-Catenin Signaling and Repressing β-Amyloid Production in an Alzheimer Mouse Model

(2018) Min Huang et al.   Frontiers in Aging Neuroscience

Antidepressants Modulate Intracellular Amyloid Peptide Species in N2a Neuroblastoma Cells

(2018) Marwa Aboukhatwa et al.   JOURNAL OF ALZHEIMERS DISEASE

Correlation Between Mini-Mental State Examination and Platelet ADAM10 Expression in Alzheimer's Disease

(2018) Patrícia Regina Manzine et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic Change in the Posterior Cingulate Gyrus in the Progression of Alzheimer's Disease

(2018) Stephen W. Scheff et al.   JOURNAL OF ALZHEIMERS DISEASE

Depression in Alzheimer's Disease: Epidemiology, Mechanisms, and Management

(2018) Song Chi et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrovascular burden and depressive symptomatology interrelate over 18 years: support for the vascular depression hypothesis

(2017) Rosanna Scott et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Efficacy of Antidepressants for Depression in Alzheimer’s Disease: Systematic Review and Meta-Analysis

(2017) Vasiliki Orgeta et al.   JOURNAL OF ALZHEIMERS DISEASE

The 2002 NIMH Provisional Diagnostic Criteria for Depression of Alzheimer’s Disease (PDC-dAD): Gauging their Validity over a Decade Later

(2017) Amir A. Sepehry et al.   JOURNAL OF ALZHEIMERS DISEASE

Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble

(2017) Vasilis Kontis et al.   LANCET

Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3×TgAD mice

(2017) Dong-Sheng Sun et al.   NEUROPHARMACOLOGY

Oxidative stress, inflammation and treatment response in major depression

(2017) Daniel Lindqvist et al.   PSYCHONEUROENDOCRINOLOGY

Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration

(2017) Duraisamy Kempuraj et al.   Frontiers in Cellular Neuroscience

Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study

(2017) Peng Li et al.   EJNMMI Research

Persistence and Adherence with Dementia Pharmacotherapy: Relevance of Patient, Provider, and System Factors

(2017) Colleen J Maxwell et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

The effect of treatment with selective serotonin reuptake inhibitors in comparison to placebo in the progression of dementia: a systematic review and meta-analysis

(2016) Helen E. Jones et al.   AGE AND AGEING

Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia

(2016) Chenkun Wang et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

MEDICATIONS FOR DEPRESSION IN ALZHEIMER’S AND RISK OF MORTALITY: A LONGITUDINAL OBSERVATIONAL STUDY FROM THE ADTI

(2016) Amir Ali Sepehry et al.   Alzheimers & Dementia

Amyloid Hypothesis: Is There a Role for Antiamyloid Treatment in Late-Life Depression?

(2016) Nahla Mahgoub et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment

(2016) Silvia Alboni et al.   BRAIN BEHAVIOR AND IMMUNITY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Persistence with antidepressant drugs in patients with dementia: a retrospective database analysis

(2016) Anke Booker et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

(2016) Qing-Fei Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

The Effect of Escitalopram on Mood and Cognition in Depressive Alzheimer’s Disease Subjects

(2016) Hoyoung An et al.   JOURNAL OF ALZHEIMERS DISEASE

Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging

(2016) Florian Schuck et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β(1–42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity

(2016) Sha Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo

(2016) Jonathan R. Fisher et al.   Molecular Neurodegeneration

TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics

(2016) M Gupta et al.   MOLECULAR PSYCHIATRY

Neuropathological relationship between major depression and dementia: A hypothetical model and review

(2016) Helena Kyunghee Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Update on SSRI Treatment for Neuropsychiatric Symptoms of Dementia

(2016) James M. Wilkins et al.   Current Psychiatry Reports

Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia

(2016) Allison R. Kaup et al.   JAMA Psychiatry

Adherence to Medication Regimens is an Effective Indicator of Cognitive Dysfunction in Elderly Individuals

(2015) Fumihiro Mizokami et al.   American Journal of Alzheimers Disease and Other Dementias

Depression and Incident Alzheimer Disease: The Impact of Disease Severity

(2015) Patricia Gracia-García et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Apathy in Late-Life Depression: Common, Persistent, and Disabling

(2015) Genevieve S. Yuen et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Longitudinal Association of Dementia and Depression

(2015) Mark B. Snowden et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Diagnosis and treatment of depression and cognitive impairment in late life

(2015) Sarah Shizuko Morimoto et al.   Annals of the New York Academy of Sciences

Involvement of inflammation in Alzheimer’s disease pathogenesis and therapeutic potential of anti-inflammatory agents

(2015) Sina Shadfar et al.   ARCHIVES OF PHARMACAL RESEARCH

Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function

(2015) Elena Dale et al.   CNS SPECTRUMS

Treatment-resistant Late-life Depression: Challenges and Perspectives

(2015) Christian Knochel et al.   Current Neuropharmacology

Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients

(2015) Matthias Brendel et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease

(2015) Michael Firbank et al.   HUMAN BRAIN MAPPING

Multicenter, randomized, placebo-controlled, double-blind clinical trial of escitalopram on the progression-delaying effects in Alzheimer's disease

(2015) Young Min Choe et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Combined treatment with memantine/es-citalopram for older depressed patients with cognitive impairment: a pilot study

(2015) Gregory H. Pelton et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease

(2015) Otávio Augusto Fernandes Marques Bianco et al.   INTERNATIONAL PSYCHOGERIATRICS

Moderation of antidepressant and placebo outcomes by baseline severity in late-life depression: A systematic review and meta-analysis

(2015) Cosima Locher et al.   JOURNAL OF AFFECTIVE DISORDERS

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

The Course of Neuropsychiatric Symptoms in Dementia: A 3-Year Longitudinal Study

(2015) Henry Brodaty et al.   Journal of the American Medical Directors Association

Integrating the monoamine, neurotrophin and cytokine hypotheses of depression — A central role for the serotonin transporter?

(2015) Jana Haase et al.   PHARMACOLOGY & THERAPEUTICS

Effects of antidepressant treatment on total antioxidant capacity and free radical levels in patients with major depressive disorder

(2015) Cheng-Chen Chang et al.   PSYCHIATRY RESEARCH

Tau aggregation and its interplay with amyloid-β

(2014) Rebecca M. Nisbet et al.   ACTA NEUROPATHOLOGICA

Amyloid-beta and depression in healthy older adults: A systematic review

(2014) Karra D Harrington et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Late-life depression in the primary care setting: Challenges, collaborative care, and prevention

(2014) Charles A. Hall et al.   MATURITAS

Global Epidemiology of Dementia: Alzheimer’s and Vascular Types

(2014) Liara Rizzi et al.   Biomed Research International

Depressive, functional status, and neuropsychiatric symptom trajectories before an Alzheimer's disease diagnosis

(2013) Joseph E. Gaugler et al.   AGING & MENTAL HEALTH

Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography

(2013) Kuan-Yi Wu et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease

(2013) Patrícia Regina Manzine et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Plasma amyloid β, depression, and dementia in community-dwelling elderly

(2013) Nese Direk et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Trends in the prevalence of antipsychotic drug use among patients with Alzheimer's disease and other dementias including those treated with antidementia drugs in the community in the UK: a cohort study

(2013) Carlos Martinez et al.   BMJ Open

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Midlife vs Late-Life Depressive Symptoms and Risk of Dementia

(2012) Kristine Yaffe   ARCHIVES OF GENERAL PSYCHIATRY

Depressive Symptoms in Mild Cognitive Impairment Predict Greater Atrophy in Alzheimer's Disease-Related Regions

(2012) Grace J. Lee et al.   BIOLOGICAL PSYCHIATRY

Effect of Selective Serotonin Reuptake Inhibitors in Alzheimer’s Disease with Comorbid Depression

(2012) Amir A. Sepehry et al.   DRUGS & AGING

Plasma Beta Amyloid Level and Depression in Older Adults

(2012) A. L. Metti et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Stay the course—is it justified?

(2012) Amir A Sepehry et al.   LANCET

A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: Do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression?

(2012) Frederick Rohan Walker   NEUROPHARMACOLOGY

Can platelet BACE1 levels be used as a biomarker for Alzheimer's disease? Proof-of-concept study

(2012) Boris Decourt et al.   PLATELETS

Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants

(2012) Seung-Yup Lee et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of persistent and incident major depression on rate of cognitive deterioration in newly diagnosed Alzheimer's disease patients

(2012) Gianfranco Spalletta et al.   PSYCHIATRY RESEARCH

Treatment of Depression in Older Adults

(2012) Cássio M. C. Bottino et al.   Current Psychiatry Reports

Alzheimer disease and platelets: how’s that relevant

(2012) Silvia Catricala et al.   Immunity & Ageing

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Depression in dementia

(2011) Daniela Enache et al.   CURRENT OPINION IN PSYCHIATRY

A Systematic Review and Meta-Analysis of Placebo-Controlled Antidepressant Studies in People with Depression and Dementia

(2011) J. Craig Nelson et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

(2011) Sube Banerjee et al.   LANCET

Serotonin signaling is associated with lower amyloid-  levels and plaques in transgenic mice and humans

(2011) J. R. Cirrito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Sertraline for the Treatment of Depression in Alzheimer Disease

(2010) Paul B. Rosenberg et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Plasma Amyloid Beta-42 Independently Predicts Both Late-Onset Depression and Alzheimer Disease

(2010) Imrich Blasko et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Peripheral inflammatory biomarkers of Alzheimer’s disease: the role of platelets

(2010) Tiziana Casoli et al.   BIOGERONTOLOGY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment

(2010) V. M. Dotson et al.   NEUROLOGY

Depression and Plasma Amyloid β Peptides in the Elderly With and Without the Apolipoprotein E4 Allele

(2009) Xiaoyan Sun et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Depression and Alzheimer's disease: Neurobiological links and common pharmacological targets

(2009) Filippo Caraci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Efficacy of Second Generation Antidepressants in Late-Life Depression: A Meta-Analysis of the Evidence

(2008) J Craig Nelson et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY