Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

The protein tyrosine kinase inhibitor, Genistein, delays intervertebral disc degeneration in rats by inhibiting the p38 pathway-mediated inflammatory response

(2020) Jun Ge et al.   Aging-US

Resveratrol Attenuates Inflammatory Bowel Disease in Mice by Regulating SUMO1

(2020) Jingyan Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Resveratrol protects human bronchial epithelial cells against nickel‐induced toxicity via suppressing p38 MAPK, NF‐κB signaling, and NLRP3 inflammasome activation

(2020) Xiangyu Cao et al.   ENVIRONMENTAL TOXICOLOGY

Apigenin alleviates renal fibroblast activation through AMPK and ERK signaling pathways in vitro

(2020) Ningning Li et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Effect of Luteolin and Apigenin on the Production of Il-31 and Il-33 in Lipopolysaccharides-Activated Microglia Cells and Their Mechanism of Action

(2020) Denis Nchang Che et al.   Nutrients

Kaempferol ameliorates Cisplatin induced nephrotoxicity by modulating oxidative stress, inflammation and apoptosis via ERK and NF-κB pathways

(2020) Zhu Wang et al.   AMB Express

Curcumin inhibits zearalenone-induced apoptosis and oxidative stress in Leydig cells via modulation of the PTEN/Nrf2/Bip signaling pathway

(2020) Si Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

The Therapeutic Potential of Apigenin

(2019) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/β-catenin axis

(2019) Chunping Zhang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

(2019) Elizabeta Zaplatic et al.   LIFE SCIENCES

Quercetin augments apoptosis of canine osteosarcoma cells by disrupting mitochondria membrane potential and regulating PKB and MAPK signal transduction

(2019) Soomin Ryu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway

(2019) Chao Li et al.   BMC Complementary and Alternative Medicine

Apigenin inhibits fibroblast proliferation and reduces epidural fibrosis by regulating Wnt3a/β-catenin signaling pathway

(2019) Rui Jiao et al.   Journal of Orthopaedic Surgery and Research

Antitumor and apoptotic effects of quercetin on human melanoma cells involving JNK/P38 MAPK signaling activation

(2019) Sung-Hyun Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apigenin, a flavonoid constituent derived from P. villosa, inhibits hepatocellular carcinoma cell growth by CyclinD1/CDK4 regulation via p38 MAPK-p21 signaling

(2019) Yue Li et al.   PATHOLOGY RESEARCH AND PRACTICE

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling

(2019) Guohua Zhu et al.   PHARMACEUTICAL BIOLOGY

Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer

(2019) Hemavathy Harikrishnan et al.   INFLAMMOPHARMACOLOGY

Effect of resveratrol on doxorubicin resistance in breast neoplasm cells by modulating PI3K/Akt signaling pathway

(2018) Ju-Min Chen et al.   IUBMB LIFE

Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies

(2018) Cing-Syuan Lei et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells

(2018) Zhaolin Chen et al.   PHYTOMEDICINE

Intranasal curcumin regulates chronic asthma in mice by modulating NF-ĸB activation and MAPK signaling

(2018) Preeti S Chauhan et al.   PHYTOMEDICINE

Preventive effect of genistein on AOM/DSS-induced colonic neoplasm by modulating the PI3K/AKT/FOXO3 signaling pathway in mice fed a high-fat diet

(2018) Shumin Song et al.   Journal of Functional Foods

Resveratrol attenuates inflammation and reduces matrix-metalloprotease expression by inducing autophagy via suppressing the Wnt/β-catenin signaling pathway in IL-1β-induced osteoarthritis chondrocytes

(2018) Ci Li et al.   RSC Advances

Quercetin attenuates AZT-induced neuroinflammation in the CNS

(2018) Yi Yang et al.   Scientific Reports

Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway

(2018) Song Fu et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Anti-inflammatory Effects of Curcumin in Microglial Cells

(2018) Yangyang Yu et al.   Frontiers in Pharmacology

Wnt/β-Catenin Signaling and Obesity

(2018) Na Chen et al.   Frontiers in Physiology

Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway

(2018) Weizheng Geng et al.   BIOMEDICINE & PHARMACOTHERAPY

Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

(2018) Jer-Hwa Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Curcumin and Quercetin Synergistically Inhibit Cancer Cell Proliferation in Multiple Cancer Cells and Modulate Wnt/β-catenin Signaling and Apoptotic Pathways in A375 Cells

(2018) Nishtha S Srivastava et al.   PHYTOMEDICINE

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

(2018) Burak Oz et al.   BIOFACTORS

Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines

(2018) S. Mohana et al.   BMC CANCER

Resveratrol Promotes Osteogenic Differentiation of Canine Bone Marrow Mesenchymal Stem Cells Through Wnt/Beta-Catenin Signaling Pathway

(2018) Xiao-e Zhao et al.   Cellular Reprogramming

Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE-19 cells

(2018) Hsiang-Wen Chien et al.   ENVIRONMENTAL TOXICOLOGY

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

(2018) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resveratrol restores sensitivity of glioma cells to temozolamide through inhibiting the activation of Wnt signaling pathway

(2018) Hua-Chao Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Modulation of Renal Insulin Signaling Pathway and Antioxidant Enzymes with Streptozotocin-Induced Diabetes: Effects of Resveratrol

(2018) Gökhan Sadi et al.   Medicina-Lithuania

An overview of structure–activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents

(2017) Laiba Arshad et al.   Future Medicinal Chemistry

Genistein attenuates pathological cardiac hypertrophy in vivo and in vitro

(2017) Y. Meng et al.   HERZ

Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action

(2017) Shimaa Ibrahim Abdelmonym Mohamed et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways

(2017) Entaz Bahar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin: the spicy modulator of breast carcinogenesis

(2017) Urmila Banik et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Safety Aspects of the Use of Quercetin as a Dietary Supplement

(2017) Susanne Andres et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin Attenuates Cell Survival, Inflammation, and Angiogenesis via Modulation of AKT Signaling in Murine T-Cell Lymphoma

(2017) Akhilendra Kumar Maurya et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Inactivated Wnt signaling in resveratrol-treated epidermal squamous cancer cells and its biological implication

(2017) Zhi-Li Liu et al.   Oncology Letters

Antitumor activity of resveratrol against human osteosarcoma cells: a key role of Cx43 and Wnt/β-catenin signaling pathway

(2017) Da Xie et al.   Oncotarget

Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascade

(2017) Guangxi Wang et al.   Scientific Reports

Curcumin Alleviates oxLDL Induced MMP-9 and EMMPRIN Expression through the Inhibition of NF-κB and MAPK Pathways in Macrophages

(2017) Jiatian Cao et al.   Frontiers in Pharmacology

The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell

(2017) Tianbao Chen et al.   BMC Pharmacology & Toxicology

Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway

(2017) Chiara Cilibrasi et al.   PLoS One

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling

(2017) Chung-Ming Lin et al.   Scientific Reports

Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis

(2017) Fu Peng et al.   Scientific Reports

Signaling mechanisms underlying the glioprotective effects of resveratrol against mitochondrial dysfunction

(2016) Bruna Bellaver et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-κB signaling pathway

(2016) Shobha Bhaskar et al.   CELLULAR IMMUNOLOGY

Understanding genistein in cancer: The “good” and the “bad” effects: A review

(2016) Maria Russo et al.   FOOD CHEMISTRY

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

(2016) Antonia Cianciulli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways

(2016) Whasun Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Curcumin induced apoptosis via PI3K/Akt-signalling pathways in SKOV3 cells

(2016) Zeshun Yu et al.   PHARMACEUTICAL BIOLOGY

Quercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases

(2016) Meghna M. Baruah et al.   TUMOR BIOLOGY

Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathway

(2016) MIN XU et al.   Oncology Letters

Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis

(2016) Hui Liu et al.   Stem Cells International

Resveratrol Ameliorates Diabetes-Induced Cardiac Dysfunction Through AT1R-ERK/p38 MAPK Signaling Pathway

(2015) Yonglin Gao et al.   Cardiovascular Toxicology

Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells

(2015) Jian Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Blockage of Wnt/β-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro

(2015) Marilia Campos Tavares Novo et al.   IMMUNOBIOLOGY

Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells

(2015) YONGGEN ZOU et al.   Molecular Medicine Reports

Natural compounds with Wnt signal modulating activity

(2015) Rolly G. Fuentes et al.   NATURAL PRODUCT REPORTS

Quercetin Regresses Dalton's Lymphoma Growth via Suppression of PI3K/AKT Signaling Leading to Upregulation of p53 and Decrease in Energy Metabolism

(2015) Akhilendra Kumar Maurya et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway

(2015) XIAOFENG LIU et al.   ONCOLOGY REPORTS

Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K/Akt signaling pathway

(2015) XIAOPING JING et al.   ONCOLOGY REPORTS

A Review: The Pharmacology of Isoliquiritigenin

(2015) Fu Peng et al.   PHYTOTHERAPY RESEARCH

Gallic acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARγ in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway

(2014) Gopalsamy Rajiv Gandhi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor ΚB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells

(2014) Jinchao Li et al.   Drug Design Development and Therapy

Targeted Regulation of PI3K/Akt/mTOR/NF-κB Signaling by Indole Compounds and their Derivatives: Mechanistic Details and Biological Implications for Cancer Therapy

(2013) Aamir Ahmad et al.   Anti-Cancer Agents in Medicinal Chemistry

Editorial (Hot Topic: Inhibition of PI3K/Akt/mTOR Signaling by Natural Products)

(2013) Shile Huang   Anti-Cancer Agents in Medicinal Chemistry

Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans

(2013) Charles-Henry Cottart et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention

(2012) Allen Y. Chen et al.   FOOD CHEMISTRY

Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway

(2012) C.-M. Liu et al.   FREE RADICAL RESEARCH

Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice

(2012) Xiaojun Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease

(2012) João Antonio Chaves de Souza et al.   Journal of Applied Oral Science

Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-κB activity

(2012) Hsieh-Hsun Ho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

(2011) SE Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crosstalk in Cellular Signaling: Background Noise or the Real Thing?

(2011) Grégory Vert et al.   DEVELOPMENTAL CELL

Kaempferol protects MC3T3-E1 cells through antioxidant effect and regulation of mitochondrial function

(2011) Eun Mi Choi   FOOD AND CHEMICAL TOXICOLOGY

Hierarchies of NF-κB target-gene regulation

(2011) Stephen T Smale   NATURE IMMUNOLOGY

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

(2010) Kyung Mi Lee et al.   BIOCHEMICAL PHARMACOLOGY

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells

(2010) Yong Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

Anti-angiogenic genistein inhibits VEGF-induced endothelial cell activation by decreasing PTK activity and MAPK activation

(2010) Xiaoping Yu et al.   MEDICAL ONCOLOGY

Quercetin Modulates NF-κ B and AP-1/JNK Pathways to Induce Cell Death in Human Hepatoma Cells

(2010) Ana Belén Granado-Serrano et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

NF-κB regulation: the nuclear response

(2009) Arun K. Mankan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction

(2009) Gabriella Marfe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Vascular pro-oxidant effects secondary to the autoxidation of gallic acid in rat aorta

(2009) José Gil-Longo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells

(2009) Yayoi Natsume et al.   TOXICOLOGY

Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells

(2008) Zhong Li et al.   CELL BIOLOGY AND TOXICOLOGY

Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells

(2008) Ana Belén Granado-Serrano et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antioxidant Effects of Different Extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus

(2008) Romaiana Picada Pereira et al.   NEUROCHEMICAL RESEARCH